scholarly journals Epidemiology of Plasmodium falciparum Malaria and Risk Factors for Severe Disease in Hubei Province, China

2020 ◽  
Vol 103 (4) ◽  
pp. 1534-1539
Author(s):  
Jing Xia ◽  
Dongni Wu ◽  
Kai Wu ◽  
Hong Zhu ◽  
Lingcong Sun ◽  
...  
Keyword(s):  
Risk Factors ◽  
Plasmodium Falciparum ◽  
Falciparum Malaria ◽  
Severe Disease ◽  
Plasmodium Falciparum Malaria ◽  
Hubei Province

scholarly journals TNFα*2 marks high risk of severe disease during Plasmodium falciparum malaria and other infections in Sri Lankans

1999 ◽  
Vol 115 (2) ◽  
pp. 350-355 ◽  
Author(s):  
J. WATTAVIDANAGE ◽  
R. CARTER ◽  
K. L. R. L. PERERA ◽  
A. MUNASINGHA ◽  
S. BANDARA ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
High Risk ◽  
Falciparum Malaria ◽  
Severe Disease ◽  
Plasmodium Falciparum Malaria

Imported Plasmodium falciparum malaria in Istanbul, Turkey: risk factors for severe course and mortality

2013 ◽  
Vol 43 (4) ◽  
pp. 129-133 ◽  
Author(s):  
Ferhat Arslan ◽  
Ali Mert ◽  
Ayse Batirel ◽  
Asuman Inan ◽  
Ilker Inanc Balkan ◽  
...  
Keyword(s):  
Risk Factors ◽  
Plasmodium Falciparum ◽  
Falciparum Malaria ◽  
Plasmodium Falciparum Malaria

scholarly journals PfEMP1-DBL1  amino acid motifs in severe disease states of Plasmodium falciparum malaria

2007 ◽  
Vol 104 (40) ◽  
pp. 15835-15840 ◽  
Author(s):  
J. Normark ◽  
D. Nilsson ◽  
U. Ribacke ◽  
G. Winter ◽  
K. Moll ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Amino Acid ◽  
Falciparum Malaria ◽  
Severe Disease ◽  
Plasmodium Falciparum Malaria ◽  
Disease States

scholarly journals Fatal Plasmodium falciparum Malaria Causes Specific Patterns of Splenic Architectural Disorganization

2005 ◽  
Vol 73 (4) ◽  
pp. 1986-1994 ◽  
Author(s):  
Britta C. Urban ◽  
Tran T. Hien ◽  
Nicholas P. Day ◽  
Nguyen H. Phu ◽  
Rachel Roberts ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Falciparum Malaria ◽  
Severe Disease ◽  
Plasmodium Falciparum Malaria ◽  
Lymphoid Organ ◽  
White Pulp ◽  
Human Malaria ◽  
Hla Dr ◽  
Repeated Infections ◽  
Marginal Zones

ABSTRACT The spleen is critical for host defense against pathogens, including Plasmodium falciparum. It has a dual role, not only removing aged or antigenically altered erythrocytes from the blood but also as the major lymphoid organ for blood-borne or systemic infections. The human malaria parasite P. falciparum replicates within erythrocytes during asexual blood stages and causes repeated infections that can be associated with severe disease. In spite of the crucial role of the spleen in the innate and acquired immune response to malaria, there is little information on the pathology of the spleen in human malaria. We performed a histological and quantitative immunohistochemical study of spleen sections from Vietnamese adults dying from severe falciparum malaria and compared the findings with the findings for spleen sections from control patients and patients dying from systemic bacterial sepsis. Here we report that the white pulp in the spleens of patients dying from malaria showed a marked architectural disorganization. We observed a marked dissolution of the marginal zones with relative loss of B cells. Furthermore, we found strong HLA-DR expression on sinusoidal lining cells but downregulation on cordal macrophages. P. falciparum infection results in alterations in splenic leukocytes, many of which are not seen in sepsis.

Risk factors of chloroquine resistance in Plasmodium falciparum malaria

Acta Tropica ◽  
1996 ◽  
Vol 61 (4) ◽  
pp. 293-306 ◽  
Author(s):  
Folke I. Hess ◽  
Aniello Iannuzzi ◽  
Judson Leafasia ◽  
David Cowdrey ◽  
Hans D. Nothdurft ◽  
...  
Keyword(s):  
Risk Factors ◽  
Plasmodium Falciparum ◽  
Falciparum Malaria ◽  
Plasmodium Falciparum Malaria ◽  
Chloroquine Resistance
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