Treatment Options for Chronic Prostatitis due to Vancomycin-Resistant Enterococcus faecium

1998 ◽  
Vol 17 (11) ◽  
pp. 798-800 ◽  
Author(s):  
S. E. Taylor ◽  
D. L. Paterson ◽  
V. L. Yu
Keyword(s):  
Enterococcus Faecium ◽  
Chronic Prostatitis ◽  
Treatment Options ◽  
Vancomycin Resistant Enterococcus ◽  
Vancomycin Resistant

scholarly journals Genomics of vancomycin-resistant Enterococcus faecium

2019 ◽  
Vol 5 (7) ◽  
Author(s):  
Claire Gorrie ◽  
Charlie Higgs ◽  
Glen Carter ◽  
Timothy P. Stinear ◽  
Benjamin Howden
Keyword(s):  
Enterococcus Faecium ◽  
Type Species ◽  
Treatment Options ◽  
World Health ◽  
Vancomycin Resistant Enterococcus ◽  
Content Type ◽  
The World ◽  
Significant Public Health ◽  
Vancomycin Resistant ◽  
New Treatments

Vancomycin-resistant Enterococcus faecium (VREfm) is a globally significant public health threat and was listed on the World Health Organization’s 2017 list of high-priority pathogens for which new treatments are urgently needed. Treatment options for invasive VREfm infections are very limited, and outcomes are often poor. Whole-genome sequencing is providing important new insights into VREfm evolution, drug resistance and hospital adaptation, and is increasingly being used to track VREfm transmission within hospitals to detect outbreaks and inform infection control practices. This mini-review provides an overview of recent data on the use of genomics to understand and respond to the global problem of VREfm.

Whole-genome analysis of vancomycin-resistant Enterococcus faecium causing nosocomial outbreaks suggests the occurrence of few endemic clonal lineages in Bavaria, Germany

2020 ◽  
Vol 75 (6) ◽  
pp. 1398-1404 ◽  
Author(s):  
David Eisenberger ◽  
Christian Tuschak ◽  
Markus Werner ◽  
Christian Bogdan ◽  
Thomas Bollinger ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Genome Analysis ◽  
Enterococcus Faecium ◽  
Treatment Options ◽  
Health Concern ◽  
Snp Analysis ◽  
Whole Genome ◽  
Vancomycin Resistant Enterococcus ◽  
Whole Genome Analysis ◽  
Vancomycin Resistant

Abstract Objectives Infections caused by vancomycin-resistant Enterococcus faecium (VREfm) represent a major public health concern due to limited treatment options. Among invasive isolates of VREfm, ST117, ST80 and ST78 represent the most frequently detected STs by MLST in Germany. In this study, we investigated the genetic diversity of isolates of VREfm recovered from different nosocomial outbreaks in Bavaria, Germany, by WGS. Methods Between January 2018 and April 2019, 99 non-replicate isolates of VREfm originating from nosocomial outbreaks at eight different hospitals in Bavaria were investigated for genetic diversity by WGS. In detail, complex types (CTs) were identified by core-genome MLST. Furthermore, an SNP analysis was performed for all VREfm strains. Results Most of the isolates of this study (76%) belonged to three major clonal groups, which occurred in at least three hospitals: ST80/CT1065 vanB (n = 45; six hospitals), ST117/CT71 vanB (n = 11; four hospitals) and ST78/CT894like vanA (n = 19; three hospitals). Moreover, isolates of the predominant lineage ST80/CT1065 vanB showed a maximum difference of 36 SNPs as revealed by SNP analysis. Conclusions Whole-genome analysis of VREfm causing nosocomial outbreaks suggests the occurrence of few endemic clonal lineages in Bavarian hospital settings, namely ST80/CT1065 vanB, ST117/CT71 vanB and ST78/CT894like vanA. Further studies are needed for a better understanding of the factors affecting the successful spread of the above-mentioned lineages.

scholarly journals Development of Daptomycin Susceptibility Breakpoints for Enterococcus faecium and Revision of the Breakpoints for Other Enterococcal Species by the Clinical and Laboratory Standards Institute

2019 ◽  
Author(s):  
Michael J Satlin ◽  
David P Nicolau ◽  
Romney M Humphries ◽  
Joseph L Kuti ◽  
Shelley A Campeau ◽  
...  
Keyword(s):  
Enterococcus Faecalis ◽  
Enterococcus Faecium ◽  
Susceptibility Testing ◽  
Treatment Options ◽  
Vancomycin Resistant Enterococcus ◽  
Standard Dosage ◽  
Enterococcal Species ◽  
Vancomycin Resistant ◽  
Infectious Diseases Consultation ◽  
Dose Dependent

Abstract Daptomycin is one of the few treatment options for infections caused by enterococci that are resistant to ampicillin and vancomycin, such as vancomycin-resistant Enterococcus faecium. The emergence and clinical significance of daptomycin-resistant enterococci and evolving microbiologic, pharmacokinetic-pharmacodynamic, and clinical data indicated that the pre-2019 Clinical and Laboratory Standards Institute (CLSI) susceptible-only breakpoint of ≤4 μg/mL for daptomycin and enterococci was no longer appropriate. After analyzing data that are outlined in this article, the CLSI Subcommittee on Antimicrobial Susceptibility Testing established new breakpoints for daptomycin and enterococci. For E. faecium, a susceptible dose-dependent (SDD) breakpoint of ≤4 μg/mL was established based on an increased dosage of 8–12 mg/kg/day (≥8 μg/mL-resistant). CLSI suggests infectious diseases consultation to guide daptomycin use for the SDD category. For Enterococcus faecalis and other enterococcal species, revised breakpoints of ≤2 μg/mL-susceptible, 4 μg/mL-intermediate, and ≥8 μg/mL-resistant were established based on a standard dosage of 6 mg/kg/day.

Anti-vancomycin-resistant Enterococcus faecium and E. faecalis activities of (-)-gossypol and derivatives from Thespesia garckeana

Planta Medica ◽  
2015 ◽  
Vol 81 (05) ◽  
Author(s):  
VM Masila ◽  
JO Midiwo ◽  
J Zhang ◽  
BM Gisacho ◽  
R Munayi ◽  
...  
Keyword(s):  
Enterococcus Faecium ◽  
Vancomycin Resistant Enterococcus ◽  
Vancomycin Resistant

Colonization pattern of vancomycin-resistant Enterococcus faecium

1994 ◽  
Vol 22 (4) ◽  
pp. 202-206 ◽  
Author(s):  
E YAMAGUCHIE ◽  
F VALENA ◽  
S SMITH ◽  
A SIMMONS ◽  
R ENG
Keyword(s):  
Enterococcus Faecium ◽  
Vancomycin Resistant Enterococcus ◽  
Colonization Pattern ◽  
Vancomycin Resistant

The Dominant Sequence Types of Vancomycin-Resistant Enterococcus faecium Among Transplantation Ward Patients

2011 ◽  
Vol 43 (8) ◽  
pp. 3132-3134 ◽  
Author(s):  
A. Mlynarczyk ◽  
K. Szymanek-Majchrzak ◽  
E. Kosykowska ◽  
W. Grzybowska ◽  
S. Tyski ◽  
...  
Keyword(s):  
Enterococcus Faecium ◽  
Vancomycin Resistant Enterococcus ◽  
Vancomycin Resistant ◽  
Sequence Types
Sign in / Sign up

Export Citation Format

Share Document