Multidrug-resistant protein inhibitor and phosphodiesterase inhibitor potentiate the vasodilator effect induced by photobiomodulation in isolated aortic rings

2021 ◽  
Author(s):  
Luis Henrique Oliveira de Moraes ◽  
Barbara Terroni ◽  
Nayara Formenton da Silva Mayer ◽  
Gerson Jhonatan Rodrigues
Keyword(s):  
Phosphodiesterase Inhibitor ◽  
Multidrug Resistant ◽  
Protein Inhibitor ◽  
Vasodilator Effect

Multidrug-Resistant Shigellosis Outbreaks

2010 ◽  
Vol 44 (7) ◽  
pp. 16
Author(s):  
MARY ANNE JACKSON
Keyword(s):  
Multidrug Resistant

Outbreaks of Multidrug-Resistant Shigella sonnei Gastroenteritis Associated with Day Care Centers--Kansas, Kentucky, and Missouri, 2005

2006 ◽  
Author(s):  
N. Obiesie ◽  
R. Flahart ◽  
G. Hansen ◽  
J. Sexton ◽  
C. Pursell ◽  
...  
Keyword(s):  
Day Care ◽  
Multidrug Resistant ◽  
Shigella Sonnei ◽  
Day Care Centers

Multidrug-Resistant TB Persists Among Immigrants

2005 ◽  
Vol 35 (13) ◽  
pp. 27
Author(s):  
HEIDI SPLETE
Keyword(s):  
Multidrug Resistant

Triterpene derivatives and their reversing activity against multidrug resistant cancer cells

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
Y Kashiwada ◽  
M Taniguchi ◽  
X Juan ◽  
T Yamagishi ◽  
Y Takaishi
Keyword(s):  
Cancer Cells ◽  
Multidrug Resistant

Risk factors for bronchiectasis exacerbations caused by multidrug-resistant microorganisms

Pneumologie ◽  
2016 ◽  
Vol 70 (10) ◽  
Author(s):  
R Menéndez ◽  
E Polverino ◽  
R Méndez ◽  
E Rosales-Mayor ◽  
I Amara-Elori ◽  
...  
Keyword(s):  
Risk Factors ◽  
Multidrug Resistant

Enhancement of Platelet Sensitivity to ADP-Aggregation by Isometric Exercise in Arteriosclerotic Patients and its Prevention

1977 ◽  
Vol 37 (02) ◽  
pp. 329-338 ◽  
Author(s):  
Tadahiro Sano ◽  
Takeshi Motomiya ◽  
Hiroh Yamazaki ◽  
Takio Shimamoto
Keyword(s):  
Cyclic Amp ◽  
Mechanical Stress ◽  
Optical Density ◽  
Platelet Function ◽  
Isometric Exercise ◽  
Phosphodiesterase Inhibitor ◽  
New Method ◽  
Platelet Aggregability ◽  
Control Subjects ◽  
Healthy Control

SummaryA new method for assessment of platelet sensitivity to ADP-aggregation was devised. Its reproducibility and the correlations between the values obtained by this method, the optical density (O. D.) method, and the screen filtration pressure (SFP) method were assessed. In summary, this method may be said to have three main points:1. It can be performed without centrifugation, avoiding mechanical stress to platelets, using only 0.8 ml. of blood and inexpensive equipment.2. It may reflect different aspects of platelet function from the O. D. method and the SFP method, despite the positive significant correlations between the values obtained by these three methods.3. It was proved to be highly reproducible and is thought to be useful clinically.By using this method, the effect of sustained isometric exercise by handgripping on platelet aggregability was assessed in coronary sclerotic and cerebral arteriosclerotic patients on placebo and EG-626, a newly synthesized cyclic AMP phosphodiesterase inhibitor. On placebo, an enhancement of platelet sensitivity was observed after isometric exercise in coronary and cerebral arteriosclerotic patients but not in healthy control subjects. The enhancement was prevented by pretreatment of EG-626, administered orally 1.5 hours prior to exercise.

Synergistic Antiplatelet Effect of Ridogrel, a Combined Thromboxane Receptor Antagonist and Thromboxane Synthase Inhibitor, and UDCG-212, a cAMP-Phosphodiesterase Inhibitor

1993 ◽  
Vol 70 (05) ◽  
pp. 822-825 ◽  
Author(s):  
B Hoet ◽  
J Arnout ◽  
H Deckmyn ◽  
J Vermylen
Keyword(s):  
Arachidonic Acid ◽  
Platelet Aggregation ◽  
Receptor Antagonist ◽  
Phosphodiesterase Inhibitor ◽  
Camp Phosphodiesterase ◽  
Thromboxane Receptor ◽  
Thromboxane Synthase Inhibitor ◽  
Thromboxane Receptor Antagonist ◽  
Synthase Inhibitor ◽  
Camp Levels

SummaryRidogrel, a combined thromboxane receptor antagonist and thromboxane synthase inhibitor (1), inhibits platelet aggregation. Following stimulation with arachidonic acid, cAMP-levels are increased in human platelets preincubated with ridogrel, this is due to the known reorientation of the metabolism of the formed endoperoxides towards adenylate cyclase stimulating prostaglandins.Pretreatment of resting platelets with UDCG-212, a cAMP-phosphodiesterase inhibitor (2), also inhibits platelet aggregation induced by arachidonic acid, concomitant with an increase in cAMP levels, due to an inhibition of its breakdown. Under basal conditions, cAMP also is increased.By combining the two drugs, a more than additive action was observed on platelet aggregation and on both resting and stimulated platelet cAMP content. The appropriate combination may result in a more effective antiplatelet strategy.

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