Prognostic value of systemic immune-inflammation index in patients with pancreatic cancer: a meta-analysis

BackgroundPrevious studies have investigated the role of systemic immune-inflammation index (SII) as a prognostic factor for gastric cancer (GC) patients, although with inconsistent results. Thus, the aim of this study was to identify the prognostic value of SII in GC through meta-analysis.MethodsWe systematically searched the PubMed, Embase, and Web of Science databases for relevant studies investigating the prognostic role of SII in GC up to December 2019. The hazard ratios (HRs) and 95% confidence intervals (CIs) related to overall survival (OS) and disease-free survival (DFS) were combined. Odds ratios (ORs) and 95% CIs were pooled to assess the correlation between SII and clinicopathological features of GC.ResultsA total of eight studies, comprising 4,236 patients, were included in this meta-analysis. Pooled analysis indicated that a high pretreatment SII predicted poor OS (HR=1.40, 95% CI=1.08–1.81, p=0.010) but not poor DFS (HR=1.30, 95% CI=0.92–1.83, p=0.140) in GC. In addition, an elevated SII correlated with an advanced tumor–node–metastasis stage (OR=2.34, 95% CI=1.40–3.92, p=0.001), T3–T4 stage (OR=2.25, 95% CI=1.34–3.77, p=0.002), positive lymph node metastasis (OR=1.79, 95% CI=1.12–2.87, p=0.016), and tumor size ≥ 5 cm (OR=2.28, 95% CI=1.62–3.22, p<0.001) in patients with GC.ConclusionsA high pretreatment SII significantly associated with poorer survival outcomes as well as several clinical characteristics in GC. We suggest that SII could be monitored to guide prognostication and provide reliable information on the risk of disease progression in GC.

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The Systemic-immune-inflammation Index Independently Predicts Survival and Recurrence in Resectable Pancreatic Cancer and its Prognostic Value Depends on Bilirubin Levels

Annals of Surgery ◽

10.1097/sla.0000000000002660 ◽

2019 ◽

Vol 270 (1) ◽

pp. 139-146 ◽

Cited By ~ 50

Author(s):

Mohammad Hosein Aziz ◽

Kostandinos Sideras ◽

Nasir Ahmad Aziz ◽

Katya Mauff ◽

Roel Haen ◽

...

Keyword(s):

Pancreatic Cancer ◽

Prognostic Value ◽

Resectable Pancreatic Cancer ◽

Immune Inflammation

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Prognostic value of platelet-to-lymphocyte ratio in pancreatic cancer: a comprehensive meta-analysis of 17 cohort studies

OncoTargets and Therapy ◽

10.2147/ott.s154162 ◽

2018 ◽

Vol Volume 11 ◽

pp. 1899-1908 ◽

Cited By ~ 17

Author(s):

Yongping Zhou ◽

Sijin Cheng ◽

Abdel Hamid Fathy ◽

Haixin Qian ◽

Yongzhao Zhao

Keyword(s):

Pancreatic Cancer ◽

Cohort Studies ◽

Prognostic Value ◽

Meta Analysis ◽

Platelet To Lymphocyte Ratio ◽

Lymphocyte Ratio

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The prognostic value of modified Glasgow Prognostic Score in pancreatic cancer: a meta-analysis

Cancer Cell International ◽

10.1186/s12935-020-01558-4 ◽

2020 ◽

Vol 20 (1) ◽

Author(s):

Huan Zhang ◽

Dianyun Ren ◽

Xin Jin ◽

Heshui Wu

Keyword(s):

Pancreatic Cancer ◽

Prognostic Value ◽

Close Association ◽

Meta Analysis ◽

Prognostic Score ◽

Prognostic Significance ◽

Glasgow Prognostic Score ◽

Cochrane Library ◽

Modified Glasgow Prognostic Score ◽

High Level

Abstract Background Several studies were conducted to explore the prognostic value of modified Glasgow Prognostic Score (mGPS) in pancreatic cancer, which reported contradictory results. The purpose of this meta-analysis was to summarize and further investigate the correlation between mGPS and overall survival (OS) in pancreatic cancer. Methods A systematic literature search was performed in PubMed, EMBASE, ISI Web of Science, Cochrane library databases and OVID to identify eligible studies published from Jan 1, 2011 to June 20, 2020. Pooled hazard ratios (HRs) with corresponding 95% confidence intervals (CIs) were used to detect the prognostic significance of mGPS in patients with pancreatic cancer. Results A total of 222 non-repetitive studies were identified, and 20 related studies that explored the association between survival outcomes and mGPS in pancreatic cancer patients were finally enrolled in this meta-analysis. The results showed a significant correlation between high level of mGPS and poor OS (HR = 1.50, 95% CI 1.20–1.89, P < 0.0001). Similar results were observed in the subgroup analyses based on the treatment regimen and research region. Conclusions Our study suggested the close association between poor prognosis and high level of mGPS, which will be helpful for future clinical applications in patients with pancreatic cancer.

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Prognostic Value of the Systemic Immune-Inflammation Index (SII) After Neoadjuvant Therapy for Patients with Resected Pancreatic Cancer

Annals of Surgical Oncology ◽

10.1245/s10434-019-08094-0 ◽

2019 ◽

Vol 27 (3) ◽

pp. 898-906 ◽

Cited By ~ 5

Author(s):

Pranav Murthy ◽

Mazen S. Zenati ◽

Amr I. Al Abbas ◽

Caroline J. Rieser ◽

Nathan Bahary ◽

...

Keyword(s):

Pancreatic Cancer ◽

Neoadjuvant Therapy ◽

Prognostic Value ◽

Immune Inflammation

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Evaluating the Prognostic Value of microRNA-203 in Solid Tumors Based on a Meta-Analysis and the Cancer Genome Atlas (TCGA) Datasets

Cellular Physiology and Biochemistry ◽

10.1159/000470649 ◽

2017 ◽

Vol 41 (4) ◽

pp. 1468-1480 ◽

Cited By ~ 18

Author(s):

Yingjie Shao ◽

Wendong Gu ◽

Zhonghua Ning ◽

Xing Song ◽

Honglei Pei ◽

...

Keyword(s):

Breast Cancer ◽

Colorectal Cancer ◽

Pancreatic Cancer ◽

Esophageal Cancer ◽

Solid Tumors ◽

Prognostic Value ◽

Meta Analysis ◽

The Cancer Genome Atlas ◽

Cancer Genome Atlas ◽

Genome Atlas

Background: It has been reported that miR-203 expression was aberrant in various types of cancers, and it could be used as a prognostic biomarker. Therefore, in this study, we aimed to evaluate the prognostic value of miR-203 expression in solid tumors by using meta-analysis and The Cancer Genome Atlas (TCGA) datasets. Methods: By doing a literature research in PubMed, Embase and the Cochrane Library (last update by December 2016), we were able to identify the studies assessing the prognostic role of miR-203 in various tumors. We then used TCGA datasets to validate the results of meta-analysis. Results:33 studies from 26 articles were qualified and enrolled in this meta-analysis. Pooled analyses showed that higher expression of miR-203 in tissues couldn’t predict poor overall survival (OS) and progression-free survival (PFS) in solid tumors. However, the results of subgroup analyses revealed that the upregulation of tissue miR-203 expression was associated with poor OS in colorectal cancer (hazard ratio (HR)=1.81, 95% confidence intervals (CI) 1.31-2.49; P<0.001), pancreatic cancer (HR=1.19, 95% CI 1.09-1.31; P<0.001) and ovarian cancer (HR=1.85, 95% CI 1.45-2.37; P<0.001); but it had opposite association in liver cancer (HR=0.52, 95% CI 0.28-0.97; P=0.040) and esophageal cancer (HR=0.41, 95% CI 0.25-0.66; P<0.001). Based on TCGA datasets, we found the same results for pancreatic cancer and esophageal cancer, but not for colorectal cancer and liver cancer. Moreover, patients with high circulating miR-203 in blood had significantly poor OS and PFS in colorectal cancer and breast cancer. Conclusion: Our study showed that the prognostic values of tissue miR-203 varied in different tumor types. In addition, the upregulation of circulating miR-203 in blood was associated with poor prognosis in colorectal cancer and breast cancer.

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