Normative Reference Values of Joint Space Width Estimated by Computer-aided Joint Space Analysis (CAJSA): The Distal Interphalangeal Joint

Abstract Background The reduction of finger joint space width (JSW) in patients with rheumatoid arthritis (RA) is strongly associated with joint destruction. Treatment with certolizumab pegol (CZP), a PEGylated anti-TNF, has been proven to be effective in RA patients. The computer-aided joint space analysis (CAJSA) provides the semiautomated measurement of joint space width at the metacarpal-phalangeal joints (MCP) based on hand radiographs. The aim of this post hoc analysis of the RAPID 1 trial was to quantify MCP joint space distance (JSD-MCP) measured by CAJSA between baseline and week 52 in RA patients treated with certolizumab pegol (CZP) plus methotrexate (MTX) compared with MTX/placebo. Methods Three hundred twenty-eight patients were included in the post hoc analysis and received placebo plus MTX, CZP 200 mg plus MTX and CZP 400 mg plus MTX. All patients underwent X-rays of the hand at baseline and week 52 as well as assessment of finger joint space narrowing of the MCP using CAJSA (Version 1.3.6; Sectra; Sweden). The joint space width (JSW) was expressed as mean joint space distance of the MCP joints I to V (JSD-MCPtotal). Results The MTX group showed a significant reduction of joint space of − 4.8% (JSD-MCPtotal), whereas in patients treated with CZP 200 mg/MTX and CZP 400 mg/MTX a non-significant change (JSD-MCPtotal + 0.6%) was observed. Over 52 weeks, participants with DAS28 remission (DAS28 ≤ 2.6) exhibited a significant joint space increase of + 3.3% (CZP 200 mg plus MTX) and + 3.9% (CZP pegol 400 mg plus MTX). Conclusion CZP plus MTX did not reduce JSD-MCPtotal estimated by CAJSA compared with MTX/placebo. Furthermore, clinical remission (DAS28 ≤ 2.6) in patients treated with CZP plus MTX was associated with an increasing JSD, indicating radiographic remission in RA.

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Arthrodesis of the Distal Interphalangeal Joint in a Horse Using Stainless Steel Baskets and Transarticular 4.5-mm Cortical Screws

Veterinary and Comparative Orthopaedics and Traumatology ◽

10.1055/s-0038-1632426 ◽

1995 ◽

Vol 08 (01) ◽

pp. 46-51 ◽

Cited By ~ 7

Author(s):

J. R. Vacek ◽

J. Schumacher ◽

C. M. Honnas

Keyword(s):

Stainless Steel ◽

Weight Bearing ◽

Varus Deformity ◽

Joint Space ◽

Distal Phalanx ◽

Interphalangeal Joint ◽

Distal Interphalangeal Joint ◽

Abnormal Posture ◽

Distal Interphalangeal ◽

Carpal Ligaments

SummaryThe distal interphalangeal joint was successfully arthrodesed in a 7-monthold horse using two 13-mm stainless steel baskets that were packed with autogenous cancellous bone and held in place with transarticular 4.5-mm cortical screws. The baskets were placed midway between the extensor process of the distal phalanx and the collateral ligament on the corresponding side of the joint. The screws were directed from the abaxial side of the middle phalanx, axially and distally through the basket and across the joint space, into the distal phalanx. Bony fusion of the distal interphalangeal joint occurred through the region occupied by the baskets as well as through the central region of the joint. The horse was free of lameness at the walk in the operated limb from the fourth until the tenth postoperative month, at which time lameness recurred as a result of sepsis in the region of the lateral implant. An additional complication was the development of a carpus varus deformity in the contralateral forelimb, presumably as a result of stretching of the lateral collateral carpal ligaments from excessive weight-bearing coupled with an abnormal posture (tripod stance) during convalescence. The horse was euthanatized 10 months after the arthodesis procedure because of severe lameness associated with sepsis in the region of the lateral implant.Arthrodesis of the distal interphalangeal joint can be accomplished by inserting perforated stainless steel baskets into the joint.Modifications in the surgical approach to avoid complications of sepsis need to be made before this technique can be recommended for clinical application.Although the horse did not survive long-term, presentation of this technique should prove useful to other investigators as they attempt to devise techniques to fuse the distal interphalangeal joint.

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Computer-Aided Joint Space Analysis (CAJSA) of the Proximal-Interphalangeal Joint—Normative Age-Related and Gender Specific Data

Academic Radiology ◽

10.1016/j.acra.2007.01.032 ◽

2007 ◽

Vol 14 (5) ◽

pp. 594-602 ◽

Cited By ~ 13

Author(s):

Alexander Pfeil ◽

Joachim Böttcher ◽

Bettina E. Seidl ◽

Max L. Schäfer ◽

Andreas Hansch ◽

...

Keyword(s):

Joint Space ◽

Proximal Interphalangeal Joint ◽

Interphalangeal Joint ◽

Specific Data ◽

Space Analysis ◽

Age Related ◽

Computer Aided ◽

And Gender ◽

Gender Specific

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AB0822 WHICH CLINICAL FACTORS INFLUENCE MINERALIZATION OF THE METACARPAL BONES AND FINGER JOINT SPACE WIDTH IN PSORIATIC ARTHRITIS?

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2020-eular.3703 ◽

2020 ◽

Vol 79 (Suppl 1) ◽

pp. 1714.1-1715

Author(s):

A. Pfeil ◽

M. Heinz ◽

D. Renz ◽

J. Böttcher ◽

G. Wolf ◽

...

Keyword(s):

Joint Space Narrowing ◽

Disease Duration ◽

Joint Space Width ◽

Joint Space ◽

Finger Joint ◽

Z Score ◽

Mineral Density ◽

Metacarpal Bones ◽

Computer Aided ◽

Space Width

Background:Metacarpal bone mineral density as measured by digital x-ray radiogrammetry (DXR-BMD) and finger joint space width quantified by computer-aided joint space analysis presented computer based and observer independent parameters for the evaluation of radiographic damage of the hand skeleton.Objectives:The aim of this study was to quantify clinical parameter which potential influence periarticular mineralisation of the metacarpal bones and finger joint space width in Psoriatic Arthritis (PsA)-patients.Methods:The study includes 201 PsA-patients. All patients received a radiograph of the hand. Bone mineral density was measured by DXR (Pronosco X-Posure System™, Version 2.0; Sectra; Sweden) and finger joint space width of all finger joints were evaluated by computer-aided joint space analysis (CAJSA, Radiogrammetry Kit, Version 1.3.6; Sectra; Sweden). The Z-Score was used as an age- and gender-independent parameter for the quantification finger joint space narrowing.Results:Regarding gender, the DXR-BMD was significant reduced with -0.028 g/cm2in women. An equivalent significant result was evaluated for finger joint space width (Z-ScoreMCP -1.07, Z-ScorePIP -0.81 and Z-ScoreDIP -0.76). The DXR-BMD was significantly lowert (-0.011 g/cm2) between the disease duration < 2 years (0.545±0.076 g/cm2) and >10 years (0.509±0.070 g/cm2). The Z-Score showed no significant change regarding the disease duration. Inflammatory activity as measured by c-reactive protein presented no impact on DXR-BMD and the Z-Score of all finger joints. Additionally, the use of corticosteroids was associated with a reduced DXR-BMD (-0.037 g/cm2) and an absence of finger joint space narrowing.Conclusion:The study highlights that the demineralisation of the metacarpal bones was associated with female gender, disease duration and the use of corticosteroids. Whereas, the prior mentioned parameters had no influence on finger joint space width. Consequently, periarticular demineralisation and finger joint space narrowing presented two different and independent radiological signs in PsA.References:N/ADisclosure of Interests:Alexander Pfeil Grant/research support from: This study Investigator Initiated Study “Automatic assessment of joint space narrowing in rheumatoid arthritis based on the Post-hoc analysis” (number: IIS-2016-110818) is a part of the of the Investigator Initiated Study “The quantification of inflammatory related periarticular bone loss in certolizumab pegol treated patients with rheumatoid arthritis” (number: IIS-2014-101458) which is supported by UCB Pharma GmbH, Monheim, Germany., Marcus Heinz: None declared, Diane Renz: None declared, Joachim Böttcher: None declared, Gunter Wolf: None declared, Peter Oelzner: None declared

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Evaluation of the diffusion of corticosteroids between the distal interphalangeal joint and navicular bursa in horses

Journal of the American Veterinary Medical Association ◽

10.2460/javma.232.9.1343 ◽

2008 ◽

Vol 232 (9) ◽

pp. 1343-1343

Author(s):

Frederik E. Pauwels ◽

James Schumacher ◽

Fernando A. Castro ◽

Troy E. Holder ◽

Roger C. Carroll ◽

...

Keyword(s):

Interphalangeal Joint ◽

Distal Interphalangeal Joint ◽

Distal Interphalangeal

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Development and evaluation of two different lameness models in meat goats, a pilot study

Translational Animal Science ◽

10.1093/tas/txaa193 ◽

2020 ◽

Vol 4 (4) ◽

Author(s):

Emily J Reppert ◽

Michael D Kleinhenz ◽

Abbie Viscardi ◽

Shawnee R Montgomery ◽

Alison R Crane ◽

...

Keyword(s):

Pilot Study ◽

Plasma Cortisol ◽

Interphalangeal Joint ◽

Health Concern ◽

Distal Interphalangeal Joint ◽

Livestock Species ◽

Meat Goats ◽

Distal Interphalangeal ◽

Maximum Temperatures

Abstract Lameness is a serious health concern for livestock species. Understanding individual animal response to pain and characterization of lameness are critical when developing appropriate treatments. The objectives of this pilot study was to evaluate two different lameness models and measures for determining response to induced lameness in meat goats. Lameness was induced by intraarticular injection into the left hind lateral claw distal interphalangeal joint with either amphotericin B (Amp-B) or kaolin-carrageenan (K-C). Response to lameness was characterized by behavior scoring, visual lameness scoring (VLS), infrared thermography (IRT) of the affected digit, pressure mat gait analysis (PMT), and plasma cortisol (CORT) analysis. Lame goats had higher VLS compared to controls (P = 0.003). Maximum temperatures measured in hooves from lame vs control goats were significantly higher (P = 0.003). Pressure mat analysis demonstrated, when compared to controls, lame goats had decreased force (P = 0.013), impulse (P = 0.007), contact pressure (P = 0.007), and contact area of the left hind limb (P = 0.009). Mean CORT levels 4 and 6 h after lameness induction were higher in lame goats (P = 0.005, P = 0.01). The two lameness methods reliably induced lameness of varying severity in healthy meat goats.

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