Simultaneous Determination of Triterpenoidal Saponins in Rat Urine After Oral Administration of Pulsatilla chinensis Extract Using HPLC–MS

2015 ◽  
Vol 78 (3-4) ◽  
pp. 231-239 ◽  
Author(s):  
Miao Miao Jin ◽  
Geng Shen Song ◽  
Ying Feng Du ◽  
Liang Cao ◽  
Hui Jun Xu ◽  
...  
Keyword(s):  
Oral Administration ◽  
Simultaneous Determination ◽  
Rat Urine ◽  
Pulsatilla Chinensis

Simultaneous determination of arctiin and its metabolites in rat urine and feces by HPLC

Fitoterapia ◽  
2013 ◽  
Vol 86 ◽  
pp. 6-12 ◽  
Author(s):  
Wei Wang ◽  
Qiang Pan ◽  
Xue-Ying Han ◽  
Jing Wang ◽  
Ri-Qiu Tan ◽  
...  
Keyword(s):  
Simultaneous Determination ◽  
Rat Urine

scholarly journals Simultaneous Determination and Pharmacokinetic Comparisons of Multi-Ingredients after Oral Administration ofRadix Salviae MiltiorrhizaeExtract, Hawthorn Extract, and a Combination of Both Extracts to Rats

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Yu-Qiang Liu ◽  
Qian Cai ◽  
Chang Liu ◽  
Feng-Wei Bao ◽  
Zhen-Qiu Zhang
Keyword(s):  
Oral Administration ◽  
Simultaneous Determination ◽  
Pharmacokinetic Study ◽  
Rosmarinic Acid ◽  
Rat Plasma ◽  
Hplc Method ◽  
Radix Salviae Miltiorrhizae ◽  
Salviae Miltiorrhizae ◽  
Hawthorn Extract

A simple and sensitive HPLC method was developed for simultaneous determination of danshensu (DSS), rosmarinic acid (RA), lithospermic acid (LA), salvianolic acid B (SAB), and hyperoside (HP) in rat plasma. This method validated was successfully applied to the pharmacokinetic study of the main active ingredients after oral administration ofRadix Salviae Miltiorrhizaeextract (SME), hawthorn extract (HTE), and a combination of both extracts (2.5 : 1) to rats. The results indicated that there have been great differences in pharmacokinetics between a single extract and a combination of both extracts. A combination of both extracts can enhance their bioavailabilities and delay the elimination of SAB and DSS in rats.

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