Dysfunction of Th1 and Th2 Lymphocytes and Change in Blood Cytokine Concentration at Various Stages of Chronic Intoxication with Organophosphorus Compounds

2014 ◽  
Vol 156 (6) ◽  
pp. 789-792 ◽  
Author(s):  
P. F. Zabrodskii ◽  
M. S. Gromov ◽  
I. Kh. Yafarova
Keyword(s):  
Organophosphorus Compounds ◽  
Cytokine Concentration ◽  
Chronic Intoxication ◽  
Th1 And Th2 Lymphocytes ◽  
Th1 And Th2

scholarly journals The change in function of Th1 and Th2-lymphocytes and cytokine profile at chronic intoxication of ethanol

2012 ◽  
Vol 1 (2) ◽  
pp. 0202
Author(s):  
Andrey A. Svistunov ◽  
Pavel F. Zabrodskii ◽  
V.G. Lim ◽  
V.F. Grichin
Keyword(s):  
Cytokine Profile ◽  
Chronic Intoxication ◽  
Th1 And Th2 Lymphocytes ◽  
Th1 And Th2

THE EFFECT OF SUBACUTE INTOXICATION WITH ETHYLENE CHLOROHYDRIN ON IMMUNE RESPONSES, TH1 AND TH2 LYMPHOCYTE FUNCTION AND CYTOKINE LEVELS IN RATS BLOOD

2017 ◽  
pp. 27-30
Author(s):  
P. F. Zabrodskii ◽  
V. V. Maslyakov ◽  
M. S. Gromov
Keyword(s):  
Immune Responses ◽  
Inflammatory Cytokine ◽  
Albino Rats ◽  
Lymphocyte Function ◽  
Ethylene Chlorohydrin ◽  
Immunoregulatory Cytokines ◽  
Cytokine Levels ◽  
Th1 And Th2 Lymphocytes ◽  
Cellular Immune ◽  
Th1 And Th2

In experiments on outbred albino rats, it was established that subacute intoxication with ethylene chlorohydrin (0.2 LD50 daily for 4 days) causes a decrease in Th1 and Th2 lymphocytes function to the same extent, diminishes parameters of humoral and cellular immune responses and the content of immunoregulatory cytokines IFN- , IL-2, IL-4 in blood, increases concentrations of pro-inflammatory cytokine IL-6 and anti-inflammatory cytokine IL-10.

Organophosphorus compounds: a hidden threat to the health and wellbeing of mankind

2020 ◽  
pp. 38-60
Author(s):  
Konstantin Gorbunov ◽  
Denis Gudkov
Keyword(s):  
Cognitive Impairment ◽  
Chronic Exposure ◽  
Organophosphorus Compounds ◽  
Acute Poisoning ◽  
Chronic Intoxication ◽  
Health And Wellbeing ◽  
Children Development ◽  
External Stimuli ◽  
Modern Technologies

Organophosphorus compounds (OPC) have been known for about 90 years: drugs and pesticides, poisons causing paralysis, convulsions and death in case of acute poisoning and leading to cancer, malformations and cognitive impairment in case of chronic exposure by doses that do not cause acute intoxication. Despite the existing measures, deaths due to OPC poisoning are recorded annually. The problem of children development after any poisoning even with small doses of these substances is especially urgent. Modern technologies provide new perspectives for the analysis of chronic intoxication by OPC, prognosis of acute poisoning severity and long-term health consequences. Research of miRNA and metabolomics came to the first place among the scientific approaches to the study of the body’s response to various external stimuli, including OPC poisoning. New methods are being developed to prevent the effects of poisoning based on stabilized bacterial enzymes, as well as modified miRNA.

Memory and flexibility of cytokine gene expression as separable properties of human TH1 and TH2 lymphocytes

10.1038/ni872 ◽  
2002 ◽  
Vol 4 (1) ◽  
pp. 78-86 ◽  
Author(s):  
Mara Messi ◽  
Isabella Giacchetto ◽  
Kinya Nagata ◽  
Antonio Lanzavecchia ◽  
Gioacchino Natoli ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cytokine Gene Expression ◽  
Cytokine Gene ◽  
Th1 And Th2 Lymphocytes ◽  
Th1 And Th2

Effect of Supplementation with Garlic Oil on Activity of Th1 and Th2 Lymphocytes from Rats

Planta Medica ◽  
2009 ◽  
Vol 75 (03) ◽  
pp. 205-210 ◽  
Author(s):  
Cheng-Tzu Liu ◽  
Hsing-Min Su ◽  
Chong-Kuei Lii ◽  
Lee-Yan Sheen
Keyword(s):  
Garlic Oil ◽  
Th1 And Th2 Lymphocytes ◽  
Th1 And Th2

5 SIGLEC-7 IS HIGHLY AND SIMILARLY EXPRESSED ON TH1 AND TH2 LYMPHOCYTES.

2006 ◽  
Vol 54 (2) ◽  
pp. S373.5-S373
Author(s):  
P. Beerelli ◽  
S. B. Meyers ◽  
L. M. Mitchell ◽  
S. D. Ghimbovschi ◽  
E. P. Hoffman ◽  
...  
Keyword(s):  
Th1 And Th2 Lymphocytes ◽  
Th1 And Th2

scholarly journals Rules of Recruitment for Th1 and Th2 Lymphocytes in Inflamed Liver: A Role for Alpha-4 Integrin and Vascular Adhesion Protein-1

Immunity ◽  
2005 ◽  
Vol 23 (2) ◽  
pp. 153-163 ◽  
Author(s):  
Claudine S. Bonder ◽  
M. Ursula Norman ◽  
Mark G. Swain ◽  
Lori D. Zbytnuik ◽  
Jun Yamanouchi ◽  
...  
Keyword(s):  
Adhesion Protein ◽  
Vascular Adhesion ◽  
Th1 And Th2 Lymphocytes ◽  
Vascular Adhesion Protein 1 ◽  
Th1 And Th2
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