Organophosphorus compounds: a hidden threat to the health and wellbeing of mankind

2020 ◽  
pp. 38-60
Author(s):  
Konstantin Gorbunov ◽  
Denis Gudkov
Keyword(s):  
Cognitive Impairment ◽  
Chronic Exposure ◽  
Organophosphorus Compounds ◽  
Acute Poisoning ◽  
Chronic Intoxication ◽  
Health And Wellbeing ◽  
Children Development ◽  
External Stimuli ◽  
Modern Technologies

Organophosphorus compounds (OPC) have been known for about 90 years: drugs and pesticides, poisons causing paralysis, convulsions and death in case of acute poisoning and leading to cancer, malformations and cognitive impairment in case of chronic exposure by doses that do not cause acute intoxication. Despite the existing measures, deaths due to OPC poisoning are recorded annually. The problem of children development after any poisoning even with small doses of these substances is especially urgent. Modern technologies provide new perspectives for the analysis of chronic intoxication by OPC, prognosis of acute poisoning severity and long-term health consequences. Research of miRNA and metabolomics came to the first place among the scientific approaches to the study of the body’s response to various external stimuli, including OPC poisoning. New methods are being developed to prevent the effects of poisoning based on stabilized bacterial enzymes, as well as modified miRNA.

Organophosphorus compounds: a hidden threat to the health and wellbeing of mankind

2020 ◽  
pp. 44-66
Author(s):  
Konstantin Gorbunov ◽  
Denis Gudkov
Keyword(s):  
Cognitive Impairment ◽  
Chronic Exposure ◽  
Organophosphorus Compounds ◽  
Acute Poisoning ◽  
Chronic Intoxication ◽  
Health And Wellbeing ◽  
Children Development ◽  
External Stimuli ◽  
Modern Technologies

Organophosphorus compounds (OPC) have been known for about 90 years: drugs and pesticides, poisons causing paralysis, convulsions and death in case of acute poisoning and leading to cancer, malformations and cognitive impairment in case of chronic exposure by doses that do not cause acute intoxication. Despite the existing measures, deaths due to OPC poisoning are recorded annually. The problem of children development after any poisoning even with small doses of these substances is especially urgent. Modern technologies provide new perspectives for the analysis of chronic intoxication by OPC, prognosis of acute poisoning severity and long-term health consequences. Research of miRNA and metabolomics came to the first place among the scientific approaches to the study of the body’s response to various external stimuli, including OPC poisoning. New methods are being developed to prevent the effects of poisoning based on stabilized bacterial enzymes, as well as modified miRNA.

Physical activity and cognitive function in older persons

2016 ◽  
Vol 64 (2) ◽  
Keyword(s):  
Physical Activity ◽  
Cognitive Impairment ◽  
Cognitive Function ◽  
Executive Functions ◽  
Cognitive Aging ◽  
Clinical Studies ◽  
Older Persons ◽  
Positive Effects ◽  
Critical Challenge

Strategies to improve cognitive aging are highly needed. Among those, promotion of exercise and physical activity appears as one of the most attractive and beneficial intervention. Indeed, results from basic and clinical studies suggest that exercise and physical activity have positive effects on cognition in older persons without cognitive impairment, as well as in those with dementia. Despite inconsistent results, aerobic exercise appears to have the strongest potential to enhance cognition. However, even limited periods of walking (45 minutes, three times a week, over a 6-month period) have also been shown to enhance cognition, particularly executive functions. Changing long-term lifestyle habits in these older persons remains a critical challenge and attractive programs susceptible to gain adherence are needed to succeed in achieving improved cognitive aging.

EXPERIENCE IN THE IMPLEMENTATION OF CONTINUOUS INTEGRATED TRAINING SYSTEM FOR SPECIALISTS OF MEDICO-PREVENTIVE BUSINESS IN THE SVERDLOVSK REGION

2018 ◽  
pp. 5-10
Author(s):  
O.P. Kovtun ◽  
S.V. Kuzmin ◽  
O.V. Dikonskaya ◽  
B.I. Nikonov ◽  
V.B. Gurvich ◽  
...  
Keyword(s):  
Graduate Training ◽  
Training System ◽  
The State ◽  
Post Graduate ◽  
Post Graduate Training ◽  
Medical University ◽  
Long Term Experience ◽  
Modern Technologies

The paper presents long-term experience of interaction between practitioners of the State Sanitary and Epidemiological Service (until 2005) and Rospotrebnadzor (since 2005), the institutions of science for Rospotrebnadzor, Ural State Medical University in preparing graduates of a medical-preventive profile, starting from pre-university work with schoolchildren to the introduction of modern technologies of practice-oriented training of students, specialists post-graduate training of the State Sanitary and Epidemiological Service and Rospotrebnadzor.

Exploring the Role of Remote Ischemic Preconditioning In Long Term Cognitive Impairment after Global Ischemia-Reperfusion-Induced Vascular Dementia in Mice

2020 ◽  
Author(s):  
Amteshwar Singh Jaggi
Keyword(s):  
Cognitive Impairment ◽  
Cerebral Ischemia ◽  
Vascular Dementia ◽  
Ischemic Preconditioning ◽  
Ischemia Reperfusion ◽  
Remote Ischemic Preconditioning ◽  
Global Cerebral Ischemia ◽  
Cerebral Ischemic ◽  
The Brain

Aim: The aim of the present study is to explore the neuroprotective effects of remote ischemic preconditioning in long term cognitive impairment after global cerebral ischemia induced-vascular dementia in mice. Material and methods: The mice were subjected to global cerebral ischemia by occluding the bilateral common carotid arteries for 12 minutes followed by the 24 hours of the reperfusion. The remote ischemic preconditioning stimulus was delivered in the form of 4 cycles of ischemia/reperfusion for 5 minutes each. The cerebral ischemic injury induced-long term cognitive impairment-related learning and memory alterations was assessed using morris water maze, the motor performances of the animals were evaluated using rota-rod test and neurological severity score. The cerebral infract size of the brain were quantified using triphenyltetrazolium chloride staining. Results: Global cerebral ischemia causes long term memory impairment, decreases motor performances and increases the brain infract size in animals. The delivery of remote ischemic preconditioning stimulus significantly abolished the long-term cognitive impairment and ameliorates the motor performances as well as cerebral infract size in brain. Conclusion: The remote ischemic preconditioning mediates neuro protection against global cerebral ischemic injury induced long-term cognitive impairment.

scholarly journals Acute and chronic exposure to air pollution in relation with incidence, prevalence, severity and mortality of COVID-19: a rapid systematic review

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Patrick D. M. C. Katoto ◽  
Amanda S. Brand ◽  
Buket Bakan ◽  
Paul Musa Obadia ◽  
Carsi Kuhangana ◽  
...  
Keyword(s):  
Air Pollution ◽  
Chronic Exposure ◽  
Ambient Air ◽  
Short Term ◽  
Incidence And Mortality ◽  
Acute And Chronic Exposure ◽  
Anthropogenic Pollutant ◽  
Incident Cases ◽  
Incidence Prevalence

Abstract Background Air pollution is one of the world’s leading mortality risk factors contributing to seven million deaths annually. COVID-19 pandemic has claimed about one million deaths in less than a year. However, it is unclear whether exposure to acute and chronic air pollution influences the COVID-19 epidemiologic curve. Methods We searched for relevant studies listed in six electronic databases between December 2019 and September 2020. We applied no language or publication status limits. Studies presented as original articles, studies that assessed risk, incidence, prevalence, or lethality of COVID-19 in relation with exposure to either short-term or long-term exposure to ambient air pollution were included. All patients regardless of age, sex and location diagnosed as having COVID-19 of any severity were taken into consideration. We synthesised results using harvest plots based on effect direction. Results Included studies were cross-sectional (n = 10), retrospective cohorts (n = 9), ecological (n = 6 of which two were time-series) and hypothesis (n = 1). Of these studies, 52 and 48% assessed the effect of short-term and long-term pollutant exposure, respectively and one evaluated both. Pollutants mostly studied were PM2.5 (64%), NO2 (50%), PM10 (43%) and O3 (29%) for acute effects and PM2.5 (85%), NO2 (39%) and O3 (23%) then PM10 (15%) for chronic effects. Most assessed COVID-19 outcomes were incidence and mortality rate. Acutely, pollutants independently associated with COVID-19 incidence and mortality were first PM2.5 then PM10, NO2 and O3 (only for incident cases). Chronically, similar relationships were found for PM2.5 and NO2. High overall risk of bias judgments (86 and 39% in short-term and long-term exposure studies, respectively) was predominantly due to a failure to adjust aggregated data for important confounders, and to a lesser extent because of a lack of comparative analysis. Conclusion The body of evidence indicates that both acute and chronic exposure to air pollution can affect COVID-19 epidemiology. The evidence is unclear for acute exposure due to a higher level of bias in existing studies as compared to moderate evidence with chronic exposure. Public health interventions that help minimize anthropogenic pollutant source and socio-economic injustice/disparities may reduce the planetary threat posed by both COVID-19 and air pollution pandemics.

scholarly journals Persistent cognitive impairment associated with cerebrospinal fluid anti-SARS-CoV-2 antibodies six months after mild COVID-19

2021 ◽  
Vol 3 (1) ◽  
Author(s):  
Max Borsche ◽  
Dirk Reichel ◽  
Anja Fellbrich ◽  
Anne S. Lixenfeld ◽  
Johann Rahmöller ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Cerebrospinal Fluid ◽  
Nervous System ◽  
Cognitive Impairment ◽  
Female Patient ◽  
Acute Phase ◽  
Neuropsychological Testing ◽  
Important Challenge ◽  
Central Nervous System Invasion

AbstractNeurological long-term sequelae are increasingly considered an important challenge in the recent COVID-19 pandemic. However, most evidence for neurological symptoms after SARS-CoV-2 infection and central nervous system invasion of the virus stems from individuals severely affected in the acute phase of the disease. Here, we report long-lasting cognitive impairment along with persistent cerebrospinal fluid anti-SARS-CoV-2 antibodies in a female patient with unremarkable standard examination 6 months after mild COVID-19, supporting the implementation of neuropsychological testing and specific cerebrospinal fluid investigation also in patients with a relatively mild acute disease phase.

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