Analysis of Healing of Rat Uterine Wall After Full-Thickness Surgical Incision

2021 ◽  
Author(s):  
N. B. Tikhonova ◽  
A. P. Milovanov ◽  
V. V. Aleksankina ◽  
T. V. Fokina ◽  
M. N. Boltovskaya ◽  
...  
Keyword(s):  
Uterine Wall ◽  
Full Thickness ◽  
Surgical Incision

scholarly journals The role of adipose tissue in the healing of rat uterine wall after a full-thickness surgical incision

2021 ◽  
Vol 10 (4) ◽  
pp. 72-80
Author(s):  
N.B. Tikhonova ◽  
◽  
A.P. Milovanov ◽  
V.V. Aleksankina ◽  
T.V. Fokina ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Uterine Wall ◽  
Uterine Horn ◽  
Morphometric Study ◽  
Full Thickness ◽  
Sprague Dawley ◽  
Surgical Incision ◽  
Laboratory Rodents ◽  
The Right

Introduction. Data about the role of components of adipose tissue in the repair of damaged uterine walls are limited, although a number of authors claim that cell-based drugs from adipose tissue have a positive effect on the repair of damaged uterine walls in laboratory rodents. Meanwhile, stem cells derived from adipose tissue are considered to be the most promising type of cells in regenerative medicine. The aim of the studywas to evaluate the adipocyte components in the uterine wall of rats in healing after a full-thickness surgi-cal incision. Materials and methods. We conducted the study on 40 female Sprague Dawley rats. The animals were sub-jected to a full-thickness longitudinal incision in the wall of the right uterine horn, with the left one serving as an intact control. We carried out morphological examinations of the uterine walls daily in 5 animals from day 1 to 7 and on day 15. The sections from paraffin blocks were stained with hematoxylin and eosin and Mallory’s trichrome staining. Immunohistochemistry detected FABP4+ adipocytes and CD68+ macrophages. The morphometric study was carried out using the Leica system (Leica, Germany). The results underwent processing in the Statistica 12 software (StatSoft). Results. We noticed the period of the most active interaction of adipose tissue with the damaged horn to last from day 3 to 15 and coincide with the macrophage activation in the healing zone. The intact left uterine horn was not involved in the interaction processes with the mesenteric adipose tissue. Starting from day 3 FABP4+ cells in the uterine wall of the operated horn formed groups, creating rounded nest-like structures. Clusters of FABP4+ cells were localized in the healing zone, near the suture material, and in the perime-trium near the mesentery attachment sites. The changes over time of the indicators of the area of cell nests depended on the localization and duration of healing. There were no FABP4+ cells in the left intact horn. Conclusion. We characterized the morphological interaction of adipose tissue with the damaged uterine wall during the first two weeks after a full-thickness surgical incision of the rat uterine horn. The results of the study indicate that adipocytes take an active part in the healing after a surgical incision of the rat uterine wall at the earliest stages. Keywords: rat uterus, hysterotomy, healing, adipocytes, macrophages

Analysis of the rat uterine wall healing after a full thickness surgical incision

2021 ◽  
Vol 172 (7) ◽  
pp. 120-124
Author(s):  
N. B. Tikhonova ◽  
◽  
A. P. Milovanov ◽  
V. V. Aleksankina ◽  
T. V. Fokina ◽  
...  
Keyword(s):  
Uterine Wall ◽  
Full Thickness ◽  
Surgical Incision

scholarly journals Trial of scar in post caesarean pregnancies

2018 ◽  
Vol 7 (3) ◽  
pp. 1173
Author(s):  
G. Kuppulakshmi ◽  
S. Saranya
Keyword(s):  
Caesarean Section ◽  
Caesarean Delivery ◽  
Uterine Wall ◽  
Perinatal Morbidity ◽  
Surgical Incision ◽  
Medical College ◽  
Caesarean Birth ◽  
Obstetric Management ◽  
One Year ◽  
Present Pregnancy

Background: The term caesarean delivery used to describe the delivery of a fetus through a surgical incision of the intact anterior uterine wall. The objective of this study was to analyse the maternal and perinatal morbidity between successful VBAC and failed vaginal delivery in cases selected for trial of labour.Methods: Prospective study conducted in Government RSRM Lying In Hospital, Government Stanley Medical College, Chennai over a period of one year from January 2017 to December 2017.Results: Trial of labour in previous caesarean section was more successful when the interval between previous caesarean and present pregnancy was between two to four years 86.40%. Conclusions: Most patients with a prior caesarean birth are candidates for VBAC. In properly selected women, a trial of labour after one previous low transverse caesarean section constitutes the best and safest form of obstetric management.

scholarly journals A case series of uterine rupture: a continuing cause of maternal and fetal morbidity!

2017 ◽  
Vol 4 (7) ◽  
pp. 2247
Author(s):  
Vinu Choudhary ◽  
Surendra Bisu
Keyword(s):  
Risk Factors ◽  
Uterine Rupture ◽  
Spontaneous Rupture ◽  
Case Series ◽  
Neonatal Morbidity ◽  
Uterine Wall ◽  
Full Thickness ◽  
Increased Risk ◽  
Associated Risk Factors ◽  
Ruptured Uterus

Background: Uterine rupture is defined as a full-thickness separation of the uterine wall and the overlying serosa. It is a rare peripartum complication associated with severe maternal and neonatal morbidity and mortality. The objective of this study was to review the incidence of ruptured uterus and evaluate associated risk factors, maternal and fetal complications.Methods: 14 case notes were reviewed for every patient with a ruptured uterus for a period of 4 years, from January 2012 to December 2015.Results: 79% patients had uterine rupture while in labour. Three patients were not in labour (two had a spontaneous rupture at 28/40 and 33/40 weeks respectively and for one patient it was found during an elective C/S). Two out of five patients with 2 previous C/S ruptured at 28 and 33 weeks respectively. Two or more C/S were associated with increased risk of pre- labour rupture uterus as highlighted by the three cases.Conclusions: Challenging diagnosis and cases of pre- labour rupture may necessitate pre- pregnancy counselling and antenatal LUS thickness USS in certain cases.

scholarly journals Giant rhinophyma: Excision with coblation assisted surgery

2014 ◽  
Vol 47 (03) ◽  
pp. 450-452 ◽  
Author(s):  
Caner Sahin ◽  
Mesut Turker ◽  
Bulent Celasun
Keyword(s):  
Skin Graft ◽  
Severe Case ◽  
Surrounding Tissue ◽  
Nasal Dorsum ◽  
Full Thickness ◽  
Full Thickness Skin Graft ◽  
Postoperative Results ◽  
Surgical Incision ◽  
Full Thickness Skin ◽  
Thickness Skin

ABSTRACTAn 83-year-old man presented with an unusually severe case of rhinophyma. Giant rhinopyhma is very rare in literature. The giant lesion was widely excised using sharp surgical incision and coblation assisted surgery. Using direct coblation to the nasal dorsum may cause edema in the surrounding tissue. There was minimal edema in surrounding tissue using this technique. A full thickness-skin graft was applied after excision. Cosmetic and functional postoperative results were satisfactory.

Management of two placenta percreta cases

2016 ◽  
Vol 5 (1) ◽  
pp. 15-18
Author(s):  
Ebru Celik ◽  
Salih Burcin Kavak ◽  
Seyda Yavuzkir ◽  
Sehmus Pala ◽  
Selcuk Kaplan ◽  
...  
Keyword(s):  
Management Strategy ◽  
Placenta Accreta ◽  
Uterine Wall ◽  
Placenta Percreta ◽  
Full Thickness ◽  
Management Options ◽  
Placental Invasion

Abstract Placental invasion anomalies are divided into three according to invasion of uterine wall as placenta accreta, increta and percreta. In placenta percreta, the most severe but the least common form, the placenta invades the full thickness of the uterine wall and also it can attach to adjacent organs in the abdomen like the bladder and rectum. It is a potentially life treating condition. There is no recommended management strategy for placenta percreta. We herein report two cases managed differently and discuss the management options in the light of the literature.

scholarly journals Laparoscopic management of a full-thickness uterine niche with subsequent pregnancy outcome

2021 ◽  
Vol 13 (4) ◽  
pp. 411-414
Author(s):  
D.Z. Kasapoglu ◽  
L.Y.O. Tang ◽  
R.A. Kadir ◽  
F Shakir
Keyword(s):  
Caesarean Section ◽  
Pregnancy Outcome ◽  
Laparoscopic Repair ◽  
Symptomatic Relief ◽  
Abnormal Uterine Bleeding ◽  
Scar Tissue ◽  
Uterine Wall ◽  
Subsequent Pregnancy ◽  
Full Thickness ◽  
Laparoscopic Management

Background: Uterine niche is the consequence of impaired healing of the myometrium following a lower segment transverse caesarean section (CS). Although there is conflicting evidence on the management of these cases, laparoscopic repair is a commonly used surgical treatment modality. Objectives: To demonstrate the management and laparoscopic repair of the niche with subsequent pregnancy outcome. Materials and Methods: We report a case of a 33-year-old patient who had a significant haematoma in the niche. The haematoma resolved after conservative management however, she remained symptomatic. Therefore, she had a laparoscopic repair. The narrated surgical video article demonstrates the dissection of the uterovesical fold overlying the niche, followed by the excision of the scar tissue and its repair with laparoscopic suturing. Ultrasound and magnetic resonance imaging images of the uterus demonstrating the haematoma at the caesarean section site, the niche after resolution of the haematoma and post-repair imaging are also provided. Main outcome measures: Repair of the niche, symptomatic relief of abnormal uterine bleeding, spontaneous conception and live birth. Ultrasonographic images also demonstrate uterine wall continuity post laparoscopic repair. Results: The patient recovered uneventfully. Full-thickness of myometrium was demonstrated with post-operative imaging and confirmed at the subsequent caesarean section. Gynaecological symptoms resolved following the repair. The patient conceived spontaneously after surgery and delivered at term by caesarean section without any complications. Conclusion: Laparoscopic management of the niche should be considered where there is a complete myometrial defect or significant thinning of the myometrium, especially in symptomatic women who desire future pregnancy.

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