CD8+ cytotoxic T cell and FOXP3+ regulatory T cell infiltration in relation to breast cancer survival and molecular subtypes

2011 ◽  
Vol 130 (2) ◽  
pp. 645-655 ◽  
Author(s):  
Fangfang Liu ◽  
Ronggang Lang ◽  
Jing Zhao ◽  
Xinmin Zhang ◽  
Gordon A. Pringle ◽  
...  
Keyword(s):  
Breast Cancer ◽  
T Cell ◽  
Regulatory T Cell ◽  
Cancer Survival ◽  
Molecular Subtypes ◽  
Breast Cancer Survival ◽  
Cell Infiltration ◽  
Cytotoxic T Cell ◽  
T Cell Infiltration

scholarly journals Association between CD8+ T-cell infiltration and breast cancer survival in 12 439 patients

2014 ◽  
Vol 25 (8) ◽  
pp. 1536-1543 ◽  
Author(s):  
H.R. Ali ◽  
E. Provenzano ◽  
S.-J. Dawson ◽  
F.M. Blows ◽  
B. Liu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
T Cell ◽  
Cancer Survival ◽  
Cd8 T Cell ◽  
Breast Cancer Survival ◽  
Cell Infiltration ◽  
T Cell Infiltration

scholarly journals CD4+ follicular helper T cell infiltration predicts breast cancer survival

2013 ◽  
Vol 123 (7) ◽  
pp. 2873-2892 ◽  
Author(s):  
Chunyan Gu-Trantien ◽  
Sherene Loi ◽  
Soizic Garaud ◽  
Carole Equeter ◽  
Myriam Libin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
T Cell ◽  
Cancer Survival ◽  
Breast Cancer Survival ◽  
Cell Infiltration ◽  
Helper T Cell ◽  
T Cell Infiltration ◽  
Follicular Helper ◽  
Follicular Helper T Cell

scholarly journals Zonal Difference and Prognostic Significance of Foxp3 Regulatory T Cell Infiltration in Breast Cancer

2014 ◽  
Vol 17 (1) ◽  
pp. 8 ◽  
Author(s):  
Sewha Kim ◽  
Anbok Lee ◽  
Woosung Lim ◽  
Sanghui Park ◽  
Min Sun Cho ◽  
...  
Keyword(s):  
Breast Cancer ◽  
T Cell ◽  
Regulatory T Cell ◽  
Prognostic Significance ◽  
Cell Infiltration ◽  
T Cell Infiltration

scholarly journals PD-L1 Expression Is Associated with Tumor FOXP3+ Regulatory T-Cell Infiltration of Breast Cancer and Poor Prognosis of Patient

2016 ◽  
Vol 7 (7) ◽  
pp. 784-793 ◽  
Author(s):  
Zhenhua Li ◽  
Pengzhi Dong ◽  
Meijing Ren ◽  
Yawen Song ◽  
Xiaolong Qian ◽  
...  
Keyword(s):  
Breast Cancer ◽  
T Cell ◽  
Regulatory T Cell ◽  
Poor Prognosis ◽  
Cell Infiltration ◽  
T Cell Infiltration

scholarly journals Modelling the interplay between the CD4$$^{+}$$/CD8$$^{+}$$ T-cell ratio and the expression of MHC-I in tumours

2021 ◽  
Vol 83 (1) ◽  
Author(s):  
Christian John Hurry ◽  
Alexander Mozeika ◽  
Alessia Annibale
Keyword(s):  
Immune Response ◽  
T Cell ◽  
Critical Level ◽  
Cell Infiltration ◽  
Cytotoxic T Cell ◽  
Mhc I ◽  
Cell Ratio ◽  
T Cell Infiltration ◽  
Immunological Mechanisms ◽  
Tcr Repertoire

AbstractDescribing the anti-tumour immune response as a series of cellular kinetic reactions from known immunological mechanisms, we create a mathematical model that shows the CD4$$^{+}$$ + /CD8$$^{+}$$ + T-cell ratio, T-cell infiltration and the expression of MHC-I to be interacting factors in tumour elimination. Methods from dynamical systems theory and non-equilibrium statistical mechanics are used to model the T-cell dependent anti-tumour immune response. Our model predicts a critical level of MHC-I expression which determines whether or not the tumour escapes the immune response. This critical level of MHC-I depends on the helper/cytotoxic T-cell ratio. However, our model also suggests that the immune system is robust against small changes in this ratio. We also find that T-cell infiltration and the specificity of the intra-tumour TCR repertoire will affect the critical MHC-I expression. Our work suggests that the functional form of the time evolution of MHC-I expression may explain the qualitative behaviour of tumour growth seen in patients.

scholarly journals Pilose antler polypeptides promote chemosensitization and T-cell infiltration of triple-negative breast cancer

2021 ◽  
Vol 85 ◽  
pp. 104664
Author(s):  
Mohan Li ◽  
Kexin Zheng ◽  
Shiliang Ma ◽  
Pengpeng Hu ◽  
Bo Yuan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
T Cell ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Cell Infiltration ◽  
T Cell Infiltration

Vaccination against galectin-1 promotes cytotoxic T-cell infiltration in melanoma and reduces tumor burden

2022 ◽  
Author(s):  
Julia Femel ◽  
Luuk van Hooren ◽  
Melanie Herre ◽  
Jessica Cedervall ◽  
Falk Saupe ◽  
...  
Keyword(s):  
T Cell ◽  
Tumor Burden ◽  
Cell Infiltration ◽  
Cytotoxic T Cell ◽  
T Cell Infiltration
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