Chronic oxidative stress causes estrogen-independent aggressive phenotype, and epigenetic inactivation of estrogen receptor alpha in MCF-7 breast cancer cells

2015 ◽  
Vol 153 (1) ◽  
pp. 41-56 ◽  
Author(s):  
Prathap Kumar S. Mahalingaiah ◽  
Logeswari Ponnusamy ◽  
Kamaleshwar P. Singh
Keyword(s):  
Breast Cancer ◽  
Oxidative Stress ◽  
Estrogen Receptor ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Estrogen Receptor Alpha ◽  
Receptor Alpha ◽  
Epigenetic Inactivation ◽  
Chronic Oxidative Stress ◽  
Mcf 7

scholarly journals Tetrahydro-iso-alpha Acids Antagonize Estrogen Receptor Alpha Activity in MCF-7 Breast Cancer Cells

2016 ◽  
Vol 2016 ◽  
pp. 1-12 ◽  
Author(s):  
Maëlle Lempereur ◽  
Claire Majewska ◽  
Amandine Brunquers ◽  
Sumalee Wongpramud ◽  
Bénédicte Valet ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Estrogen Receptor Alpha ◽  
Foam Stability ◽  
Binding Motif ◽  
Brewing Industry ◽  
Receptor Alpha ◽  
Mcf 7

Tetrahydro-iso-alpha acids commonly called THIAA or Tetra are modified hop acids extracted from hop (Humulus lupulusL.) which are frequently used in brewing industry mainly in order to provide beer bitterness and foam stability. Interestingly, molecular structure of tetrahydro-iso-alpha acids is close to a new type of estrogen receptor alpha (ERα) antagonists aimed at disrupting the binding of coactivators containing an LxxLL motif (NR-box). In this work we show that THIAA decreases estradiol-stimulated proliferation of MCF-7 (ERα-positive breast cancer cells). Besides, we show that it inhibits ERαtranscriptional activity. Interestingly, this extract fails to compete with estradiol for ERαbinding and does not significantly impact the receptor turnover rate in MCF-7 cells, suggesting that it does not act like classical antiestrogens. Hence, we demonstrate that THIAA is able to antagonize ERαestradiol-induced recruitment of the LxxLL binding motif.

Mechanisms governing the accumulation of estrogen receptor alpha in MCF-7 breast cancer cells treated with hydroxytamoxifen and related antiestrogens

2003 ◽  
Vol 87 (2-3) ◽  
pp. 207-221 ◽  
Author(s):  
Ioanna Laı̈os ◽  
Fabrice Journe ◽  
Guy Laurent ◽  
Denis Nonclercq ◽  
Robert-Alain Toillon ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Estrogen Receptor Alpha ◽  
Receptor Alpha ◽  
Mcf 7
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