Age-related risk factors associated with primary contralateral breast cancer among younger women versus older women

2018 ◽  
Vol 173 (3) ◽  
pp. 657-665 ◽  
Author(s):  
Tae In Yoon ◽  
Beom Seok Kwak ◽  
On Vox Yi ◽  
Seonok Kim ◽  
Eunhae Um ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Older Women ◽  
Contralateral Breast Cancer ◽  
Contralateral Breast ◽  
Younger Women ◽  
Factors Associated ◽  
Age Related ◽  
Related Risk

scholarly journals Risk of contralateral breast cancer according to first breast cancer characteristics among women in the USA, 1992–2016

2021 ◽  
Vol 23 (1) ◽  
Author(s):  
Cody Ramin ◽  
Diana R. Withrow ◽  
Brittny C. Davis Lynn ◽  
Gretchen L. Gierach ◽  
Amy Berrington de González
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Cumulative Incidence ◽  
Contralateral Breast Cancer ◽  
Breast Cancer Treatment ◽  
Contralateral Breast ◽  
Breast Cancer Patients ◽  
Younger Women ◽  
Er Positive

Abstract Background Estimates of contralateral breast cancer (CBC) risk in the modern treatment era by year of diagnosis and characteristics of the first breast cancer are needed to assess the impact of recent advances in breast cancer treatment and inform clinical decision making. Methods We examined CBC risk among 419,818 women (age 30–84 years) who were diagnosed with a first unilateral invasive breast cancer and survived ≥ 1 year in the US Surveillance, Epidemiology, and End Results program cancer registries from 1992 to 2015 (follow-up through 2016). CBC was defined as a second invasive breast cancer in the contralateral breast ≥ 12 months after the first breast cancer. We estimated standardized incidence ratios (SIRs) of CBC by year of diagnosis, age at diagnosis, and tumor characteristics for the first breast cancer. Cumulative incidence of CBC was calculated for women diagnosed with a first breast cancer in the recent treatment era (2004–2015, follow-up through 2016). Results Over a median follow-up of 8 years (range 1–25 years), 12,986 breast cancer patients developed CBC. Overall, breast cancer patients had approximately twice the risk of developing cancer in the contralateral breast when compared to that expected in the general population (SIR = 2.21, 95% CI = 2.17–2.25). SIRs for CBC declined by year of first diagnosis, irrespective of age at diagnosis and estrogen receptor (ER) status (p-trends < 0.001), but the strongest decline was after an ER-positive tumor. The 5-year cumulative incidence of CBC ranged from 1.01% (95% CI = 0.90–1.14%) in younger women (age < 50 years) with a first ER-positive tumor to 1.89% (95% CI = 1.61–2.21%) in younger women with a first ER-negative tumor. Conclusion Declines in CBC risk are consistent with continued advances in breast cancer treatment. The updated estimates of cumulative incidence inform breast cancer patients and clinicians on the risk of CBC and may help guide treatment decisions.

scholarly journals Mammogram history in Nigerian women: Age-related risk factors for breast cancer and educational implications

2018 ◽  
Vol 2 ◽  
Author(s):  
Eric O. Umeh ◽  
Kanayo F. Umeh ◽  
Uzoamaka R. Ebubedike ◽  
Chiamaka F. Ezeugbor ◽  
Chukwuziem N. Anene
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Mammography Screening ◽  
Public Awareness ◽  
Sub Saharan Africa ◽  
Chronological Age ◽  
Nigerian Women ◽  
Awareness Campaigns ◽  
Age Related ◽  
Related Risk

Background: Breast cancer accounts for 25% of diagnosed cancers and 20% of cancer-related mortality in women from sub-Saharan Africa. Given the early onset of breast cancer in African women, there is a need to better understand how age-related risk factors contribute to mammography uptake in this population.Aim: To identify age-related risk factors for breast cancer associated with previous uptake of mammograms in asymptomatic Nigerian women and consider implications for health education campaigns.Method: Participants comprised 544 asymptomatic Nigerian women (aged 28–75 years) responding to breast cancer public awareness campaigns, by presenting for baseline or screening mammography at a local hospital. Information about mammography history and age-related risk factors (menarche, menopausal and chronological age) were obtained by interviewing the participants face-to-face, before proceeding with mammography. Hierarchical logistic regression was used to estimate the odds of previous mammograms based on the age-related risk factors.Results: The likelihood of previous mammography screening increased by a factor of 1.07 (95% confidence interval [CI]: 1.00–1.14) for every year older chronologically and decreased by a factor of 1.12 (95% CI: 1.24–1.01) for every year older at menarche. Age at menarche partly mediated the relationship between chronological age and mammography history (effect = –0.01, 95% CI: –0.01, –0.00). Women with a history of breast cancer were 6.11 times more likely to have previously undertaken mammography screening (95% CI: 2.49–14.97). Age at menopause and age at first confinement were unrelated to mammography history.Conclusions: Nigerian women may recognise the need for mammograms because of adverse age-related risk factors for breast cancer, notably menarche and chronological age. However, awareness of menopausal age as a risk factor and basis for mammography screening may be deficient. It is therefore recommended that public awareness campaigns should emphasise the importance of older menopausal age in breast cancer risk and as a basis for requesting mammograms.

Contralateral Breast Cancer: Factors Associated with Stage and Size at Presentation

2004 ◽  
Vol 10 (4) ◽  
pp. 304-312 ◽  
Author(s):  
Wilson C. Mertens ◽  
Veronica Hilbert ◽  
Grace Makari-Judson
Keyword(s):  
Breast Cancer ◽  
Contralateral Breast Cancer ◽  
Contralateral Breast ◽  
Factors Associated

Risk factors for metachronous contralateral breast cancer: A systematic review and meta-analysis

The Breast ◽  
2019 ◽  
Vol 44 ◽  
pp. 1-14 ◽  
Author(s):  
Delal Akdeniz ◽  
Marjanka K. Schmidt ◽  
Caroline M. Seynaeve ◽  
Danielle McCool ◽  
Daniele Giardiello ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Systematic Review ◽  
Contralateral Breast Cancer ◽  
Meta Analysis ◽  
Contralateral Breast

Tumor Stage Affects Risk and Prognosis of Contralateral Breast Cancer: Results From a Large Swedish-Population–Based Study

2012 ◽  
Vol 30 (28) ◽  
pp. 3478-3485 ◽  
Author(s):  
Voralak Vichapat ◽  
Hans Garmo ◽  
Marit Holmqvist ◽  
Göran Liljegren ◽  
Fredrik Wärnberg ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Primary Tumor ◽  
Primary Breast Cancer ◽  
Contralateral Breast Cancer ◽  
Cox Regression ◽  
Short Interval ◽  
Contralateral Breast ◽  
Increased Risk

Purpose The number of breast cancer survivors at risk of developing contralateral breast cancer (CBC) is increasing. However, ambiguity remains regarding risk factors and prognosis for women with CBC. Patients and Methods In a cohort of 42,670 women with breast cancer in the Uppsala/Örebro and Stockholm regions in Sweden in 1992 to 2008, we assessed risk factors for and prognosis of metachronous CBC by using survival analysis. Breast cancer–specific survival for women with CBC was evaluated and compared with results for women with unilateral breast cancer (UBC) by using time-dependent Cox-regression modeling. Results An increased risk for CBC was observed among women who had primary breast cancer with ≥ 10 involved lymph nodes compared with node-negative women (adjusted hazard ratio [HR], 1.8; 95% CI, 1.2 to 2.7). The prognosis was poorer in women with CBC than with UBC. The hazard of dying from breast cancer was especially high for women with a short interval time to CBC (adjusted HR, 2.3; 95% CI, 1.8 to 2.8 for CBC diagnosed ≤ 5 years v UBC) and gradually decreased with longer follow-up time but remained higher than the hazard originating from the primary tumor for ≥ 10 years. Conclusion Women with advanced-stage primary breast cancer had an increased risk of developing CBC. CBC is associated with an increased risk of dying from breast cancer throughout a long period of follow-up after the primary tumor. Our findings suggest that the event of CBC marks a new clinical situation in terms of investigations for metastases, treatment considerations, and follow-up strategy.

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