scholarly journals Risk factors for contralateral breast cancer in postmenopausal breast cancer survivors in the NIH-AARP Diet and Health Study

2021 ◽  
Author(s):  
Cody Ramin ◽  
Maeve Mullooly ◽  
Sara J. Schonfeld ◽  
Pragati G. Advani ◽  
Clara Bodelon ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Cancer Survivors ◽  
Breast Cancer Survivors ◽  
Contralateral Breast Cancer ◽  
Postmenopausal Breast Cancer ◽  
Contralateral Breast ◽  
Health Study

scholarly journals Nomogram to predict contralateral breast cancer risk in breast cancer survivors

Medicine ◽  
2021 ◽  
Vol 100 (46) ◽  
pp. e27595
Author(s):  
Jiaci Tong ◽  
Dewei Tan ◽  
Jing Ma ◽  
Ye Hu ◽  
Man Li
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Cancer Survivors ◽  
Breast Cancer Survivors ◽  
Contralateral Breast Cancer ◽  
Contralateral Breast

scholarly journals Risk factors for lymphedema in breast cancer survivors, the Iowa Women’s Health Study

2011 ◽  
Vol 130 (3) ◽  
pp. 981-991 ◽  
Author(s):  
Rehana L. Ahmed ◽  
Kathryn H. Schmitz ◽  
Anna E. Prizment ◽  
Aaron R. Folsom
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Cancer Survivors ◽  
Women’S Health ◽  
Women's Health ◽  
Breast Cancer Survivors ◽  
Health Study ◽  
Iowa Women's Health Study

scholarly journals Relationship Between Potentially Modifiable Lifestyle Factors and Risk of Second Primary Contralateral Breast Cancer Among Women Diagnosed With Estrogen Receptor–Positive Invasive Breast Cancer

2009 ◽  
Vol 27 (32) ◽  
pp. 5312-5318 ◽  
Author(s):  
Christopher I. Li ◽  
Janet R. Daling ◽  
Peggy L. Porter ◽  
Mei-Tzu C. Tang ◽  
Kathleen E. Malone
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Cancer Survivors ◽  
Invasive Breast Cancer ◽  
Breast Cancer Survivors ◽  
Contralateral Breast Cancer ◽  
Contralateral Breast ◽  
Alcoholic Beverages ◽  
Second Primary

Purpose An outcome of considerable concern among breast cancer survivors is the development of second primary breast cancer. However, evidence regarding how potentially modifiable lifestyle factors modulate second breast cancer risk is limited. We evaluated the relationships between obesity, alcohol consumption, and smoking on risk of second primary invasive contralateral breast cancer among breast cancer survivors. Methods Utilizing a population-based nested case-control study design, we enrolled 365 patients diagnosed with an estrogen receptor–positive (ER+) first primary invasive breast cancer and a second primary contralateral invasive breast cancer, and 726 matched controls diagnosed with only an ER+ first primary invasive breast cancer. Obesity, alcohol use, and smoking data were ascertained from medical record reviews and participant interviews. Using conditional logistic regression we evaluated associations between these three exposures and second primary contralateral breast cancer risk. Results Obesity, consumption of ≥ 7 alcoholic beverages per week, and current smoking were all positively related to risk of contralateral breast cancer (odds ratio [OR], 1.4; 95% CI, 1.0 to 2.1; OR, 1.9; 95% CI, 1.1 to 3.2; and OR, 2.2; 95% CI, 1.2 to 4.0, respectively). Compared with women who consumed fewer than seven alcoholic beverages per week and were never or former smokers, women who consumed ≥ 7 drinks per week and were current smokers had a 7.2-fold (95% CI, 1.9 to 26.5) elevated risk of contralateral breast cancer. Conclusion Our population-based study adds to the limited available literature and suggests that obesity, smoking, and alcohol consumption influence contralateral breast cancer risk, affording breast cancer survivors three means of potentially reducing this risk.

Atherosclerotic disease and cardiovascular risk factors in postmenopausal breast cancer survivors: a case–control study

Climacteric ◽  
2019 ◽  
Vol 22 (2) ◽  
pp. 202-207 ◽  
Author(s):  
M. Terra Branco ◽  
D. de Araujo Brito Buttros ◽  
E. Carvalho-Pessoa ◽  
M. Lima Sobreira ◽  
C. Yukie Nakano Schincariol ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cancer Survivors ◽  
Cardiovascular Risk Factors ◽  
Breast Cancer Survivors ◽  
Case Control Study ◽  
Postmenopausal Breast Cancer ◽  
Case Control ◽  
Control Study

Survival impact of adjuvant tamoxifen on competing causes of mortality in breast cancer survivors, with analysis of mortality from contralateral breast cancer, cardiovascular events, endometrial cancer, and thromboembolic episodes.

1998 ◽  
Vol 16 (6) ◽  
pp. 2018-2024 ◽  
Author(s):  
J Ragaz ◽  
A Coldman
Keyword(s):  
Breast Cancer ◽  
Endometrial Cancer ◽  
Cancer Survivors ◽  
Primary Breast Cancer ◽  
Cardiovascular Events ◽  
Breast Cancer Survivors ◽  
Contralateral Breast Cancer ◽  
Contralateral Breast ◽  
Mortality Reduction

PURPOSE This study provides estimates of the effect of tamoxifen treatment on mortality from four conditions known to be affected by tamoxifen in women who survive their breast cancer: contralateral breast cancer, cardiovascular events, endometrial cancer, and thromboembolic events. These estimates are in addition to tamoxifen's impact on primary breast cancer mortality. METHODS The effects of tamoxifen were calculated by the use of the published relative risk (RR) rates of the four conditions as affected by adjuvant tamoxifen and their application to the respective Canadian age-specific mortality rates for the same conditions. The final mortality impact of tamoxifen was expressed as net mortality difference between users and nonusers of tamoxifen. RESULTS At 10 years of follow-up, the sum of avoided deaths (contralateral breast cancer, cardiovascular events) and excess deaths (uterine cancer, thromboembolic episodes) resulted in an overall (net) mortality reduction because of tamoxifen use, with 3 to 41 avoided deaths per 1,000 tamoxifen-treated patients who were 50 to 80 years of age. With the follow-up projected until the age of 90 years, the numbers of avoided late deaths attributed to tamoxifen ranged from 38 to 56 per 1,000 patients. CONCLUSION Our calculations that pertain to late breast cancer survivors indicate that there is a more substantial mortality reduction as a result of deaths avoided from contralateral breast cancer and cardiovascular events, despite the moderately increased mortality from endometrial cancer and thromboembolic episodes. The overall tamoxifen-associated mortality reduction occurs, in different magnitudes, in patients of all ages from 50 to 80 years at diagnosis of the primary breast cancer.

scholarly journals Vitamin D Deficiency in Postmenopausal Breast Cancer Survivors

2012 ◽  
Vol 21 (4) ◽  
pp. 456-462 ◽  
Author(s):  
Claire F. Friedman ◽  
Angela DeMichele ◽  
H. Irene Su ◽  
Rui Feng ◽  
Shiv Kapoor ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Cancer Survivors ◽  
Vitamin D Deficiency ◽  
Breast Cancer Survivors ◽  
Postmenopausal Breast Cancer

scholarly journals Assessment of Potential Risk Factors and Skin Ultrasound Presentation Associated with Breast Cancer-Related Lymphedema in Long-Term Breast Cancer Survivors

Diagnostics ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1303
Author(s):  
Khairunnisa’ Md Yusof ◽  
Kelly A. Avery-Kiejda ◽  
Shafinah Ahmad Suhaimi ◽  
Najwa Ahmad Zamri ◽  
Muhammad Ehsan Fitri Rusli ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Cancer Survivors ◽  
Potential Risk ◽  
Breast Cancer Survivors ◽  
Ultrasound Examination ◽  
Arm Circumference ◽  
Potential Risk Factors ◽  
Breast Cancer Related Lymphedema

Breast cancer has been reported to have the highest survival rate among various cancers. However, breast cancer survivors face several challenges following breast cancer treatment including breast cancer-related lymphedema (BCRL), sexual dysfunction, and psychological distress. This study aimed to investigate the potential risk factors of BCRL in long term breast cancer survivors. A total of 160 female breast cancer subjects were recruited on a voluntary basis and arm lymphedema was assessed through self-reporting of diagnosis, arm circumference measurement, and ultrasound examination. A total of 33/160 or 20.5% of the women developed BCRL with significantly higher scores for upper extremity disability (37.14 ± 18.90 vs. 20.08 ± 15.29, p < 0.001) and a lower score for quality of life (103.91 ± 21.80 vs. 115.49 ± 16.80, p = 0.009) as compared to non-lymphedema cases. Univariate analysis revealed that multiple surgeries (OR = 5.70, 95% CI: 1.21–26.8, p < 0.001), axillary lymph nodes excision (>10) (OR = 2.83, 95% CI: 0.94–8.11, p = 0.047), being overweight (≥25 kg/m2) (OR = 2.57, 95% CI: 1.04 – 6.38, p = 0.036), received fewer post-surgery rehabilitation treatment (OR = 2.37, 95% CI: 1.05–5.39, p = 0.036) and hypertension (OR = 2.38, 95% CI: 1.01–5.62, p = 0.043) were associated with an increased risk of BCRL. Meanwhile, multivariate analysis showed that multiple surgeries remained significant and elevated the likelihood of BCRL (OR = 5.83, 95% CI: 1.14–29.78, p = 0.034). Arm swelling was more prominent in the forearm area demonstrated by the highest difference of arm circumference measurement when compared to the upper arm (2.07 ± 2.48 vs. 1.34 ± 1.91 cm, p < 0.001). The total of skinfold thickness of the affected forearm was also significantly higher than the unaffected arms (p < 0.05) as evidenced by the ultrasound examination. The continuous search for risk factors in specific populations may facilitate the development of a standardized method to reduce the occurrence of BCRL and provide better management for breast cancer patients.

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