Thyroid cancer in the Middle Eastern population of California

2008 ◽  
Vol 19 (10) ◽  
pp. 1183-1191 ◽  
Author(s):  
Kiumarss Nasseri
Keyword(s):  
Thyroid Cancer ◽  
Middle Eastern ◽  
Eastern Population ◽  
Middle Eastern Population

RAD52 polymorphisms contribute to the development of papillary thyroid cancer susceptibility in Middle Eastern population

2008 ◽  
Vol 31 (10) ◽  
pp. 893-899 ◽  
Author(s):  
A. K. Siraj ◽  
M. Al-Rasheed ◽  
M. Ibrahim ◽  
K. Siddiqui ◽  
F. Al-Dayel ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Cancer Susceptibility ◽  
Middle Eastern ◽  
Papillary Thyroid ◽  
Eastern Population ◽  
Middle Eastern Population

scholarly journals Clinicopathological Analysis of Papillary Thyroid Cancer withPIK3CAAlterations in a Middle Eastern Population

2008 ◽  
Vol 93 (2) ◽  
pp. 611-618 ◽  
Author(s):  
Jehad Abubaker ◽  
Zeenath Jehan ◽  
Prashant Bavi ◽  
Mehar Sultana ◽  
Sayer Al-Harbi ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Middle Eastern ◽  
Papillary Thyroid ◽  
Eastern Population ◽  
Clinicopathological Analysis ◽  
Middle Eastern Population

HABP2 Gene Mutations Do Not Cause Familial or Sporadic Non-Medullary Thyroid Cancer in a Highly Inbred Middle Eastern Population

Thyroid ◽  
2016 ◽  
Vol 26 (5) ◽  
pp. 667-671 ◽  
Author(s):  
Ali S. Alzahrani ◽  
Avaniyapuram Kannan Murugan ◽  
Ebtesam Qasem ◽  
Hindi Al-Hindi
Keyword(s):  
Thyroid Cancer ◽  
Medullary Thyroid Cancer ◽  
Middle Eastern ◽  
Gene Mutations ◽  
Eastern Population ◽  
Medullary Thyroid ◽  
Middle Eastern Population

scholarly journals REPRODUCTIBILITY OF A METABOLITE RISK SCORE TO PREDICT CORONARY HEART DISEASE IN A MIDDLE EASTERN POPULATION

2021 ◽  
Vol 77 (18) ◽  
pp. 107
Author(s):  
Ayman El-Menyar ◽  
Ehsan Ullah ◽  
Khalid Kunji ◽  
Reem Elsousy ◽  
Amna Al-Nesf ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Risk Score ◽  
Middle Eastern ◽  
Eastern Population ◽  
Middle Eastern Population

scholarly journals TERT promoter mutations in thyroid cancer: a report from a Middle Eastern population

2015 ◽  
Vol 22 (6) ◽  
pp. 901-908 ◽  
Author(s):  
Ebtesam Qasem ◽  
Avaniyapuram Kannan Murugan ◽  
Hindi Al-Hindi ◽  
Mingzhao Xing ◽  
Mai Almohanna ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Middle East ◽  
Direct Sequencing ◽  
Tumour Size ◽  
Middle Eastern ◽  
Middle Eastern Population ◽  
Thyroid Adenomas ◽  
Cell Variant ◽  
Hürthle Cell Thyroid Cancer ◽  
Promoter Mutations

Telomerase reverse transcriptase (TERT) promoter mutations C228T and C250T have recently been described in follicular cell-derived thyroid cancer (TC) in patients from North America and Europe. In this study, we explored whether these findings could be replicated in patients from a different ethnic group. We screened 17 benign thyroid adenomas and 265 TC samples from patients in the Middle East for these mutations by PCR and direct sequencing using DNA isolated from paraffin-embedded tumor tissues. None of the 17 benign adenomas harbored TERT promoter mutations. Of 265 TC, 34 (12.8%) harbored TERT promoter mutations, including 10/153 (6.5%) conventional papillary TC (CPTC), 8/57 (14.0%) follicular variant PTC, 9/30 (30%) tall cell variant PTC, 1/3 (30%) Hurthle cell thyroid cancer (HTC), 1/5 (20%) follicular TC, and 5/13 (38.5%) poorly differentiated TC. C250T mutation was present in only 6/265 (2.3%) cases, while C228T mutation was present in a total of 28/265 (10.6%) cases. These two mutations were mutually exclusive. TERT promoter mutations were significantly more common in older (≥45 years) than younger patients and were associated with larger tumour size, vascular invasion, higher TNM stage (stage III and IV), BRAFV600E mutation and persistent/recurrent disease at 6–12 months after initial treatment and at the last follow up. These associations were stronger in non-CPTC. Thus, this study on a large cohort of TC patients from Middle East demonstrates that TERT promoter mutations are relatively common, especially in the non-CPTC, and are associated with more aggressive histopathological features, BRAFV600E mutation, and disease persistence/recurrence than the WT TERT.

scholarly journals Validation of the Framingham hypertension risk score in a middle eastern population: Tehran lipid and glucose study (TLGS)

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Fatemeh Koohi ◽  
Ewout W. Steyerberg ◽  
Leila Cheraghi ◽  
Alireza Abdshah ◽  
Fereidoun Azizi ◽  
...  
Keyword(s):  
Simple Model ◽  
Risk Score ◽  
Screening Tool ◽  
Middle Eastern ◽  
Predictive Ability ◽  
Eastern Population ◽  
Hypertension Risk ◽  
Graphical Comparison ◽  
Middle Eastern Population

Abstract Background The Framingham hypertension risk score is a well-known and simple model for predicting hypertension in adults. In the current study, we aimed to assess the predictive ability of this model in a Middle Eastern population. Methods We studied 5423 participants, aged 20–69 years, without hypertension, who participated in two consecutive examination cycles of the Tehran Lipid and Glucose Study (TLGS). We assessed discrimination based on Harrell’s concordance statistic (c-index) and calibration (graphical comparison of predicted vs. observed). We evaluated the original, recalibrated (for intercept and slope), and revised (for beta coefficients) models. Results Over the 3-year follow-up period, 319 participants developed hypertension. The Framingham hypertension risk score performed well in discriminating between individuals who developed hypertension and those who did not (c-index = 0.81, 95% CI: 0.79–0.83). Initially, there was a systematic underestimation of the original risk score (events predicted), which was readily corrected by a simple model revision. Conclusions The revised Framingham hypertension risk score can be used as a screening tool in public health and clinical practice to facilitate the targeting of preventive interventions in high-risk Middle Eastern people.

scholarly journals Molecular Characterization of Prostate Cancer in Middle Eastern Population Highlights Differences with Western Populations with Prognostic Implication

2019 ◽  
Author(s):  
Ramy A. Abdelsalam ◽  
Ibrahim Khalifeh ◽  
Alan Box ◽  
Maria Kalantarian ◽  
Sunita Ghosh ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Middle Eastern ◽  
Genomic Alteration ◽  
Published Data ◽  
Lower Grade ◽  
Eastern Population ◽  
Western Population ◽  
Pten Loss ◽  
Middle Eastern Population ◽  
Grade Groups

Abstract Background To investigate the incidence and prognostication of ERG, PTEN and SPINK1 protein expressions in prostate cancer cohort of Middle Eastern descent in comparison to published data from Western populationMethods Immunohistochemistry for ERG, PTEN and SPINK1 was performed in cohort of localized PCa (n=340). Data correlated to pathological and clinical outcomes and compared to Western populations.Results ERG expression and PTEN loss noted in 123/288 (42.7%) and 91/297 (30.6%) of patients, respectively. SPINK1 expression assessed in subset of cases, noted in 6/150 (4%) of patients. Only ERG expression was associated with grade groups, being more common in lower grade groups (1-3 vs 4-5; p=0.04). In contrast to Western population, PTEN loss foci were more likely to be ERG negative, observed in 81% of tumor foci and patients with PTEN neg/ERG pos were more likely to exhibit biochemical recurrence (OR 2.831; 95% CI: 1.10-726, p=0.03). This association remained significant in multivariate analysis (OR 2.68; 95% CI: 0.98-7.33, p=0.05), after adjusting for GG, path stage and surgical margin.Conclusion This study documents significant differences in key molecular events in PCa in Middle Eastern population compared to Western populations that could explain differences in PCa incidence, progression and prognostication. ERG, PTEN and SPINK1 genomic alteration occur less frequently and the enrichment of ERG for PTEN loss is not observed. Additionally, patients with combined PTEN loss/ERG positive are at highest rate for BCR vs North American Caucasian population where PTEN loss alone seems to be associated with the worst clinical outcome. The data presented here further support differences in clonal evolution between Middle Eastern and Western population in relation to PCa and add further insight to understanding PCa molecular pathways.

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