Late-Onset Dietary Restriction Modulates Protein Carbonylation and Catalase in Cerebral Hemispheres of Aged Mice

2013 ◽  
Vol 34 (2) ◽  
pp. 307-313 ◽  
Author(s):  
Preeticia Dkhar ◽  
Ramesh Sharma
Keyword(s):  
Dietary Restriction ◽  
Late Onset ◽  
Protein Carbonylation ◽  
Cerebral Hemispheres ◽  
Aged Mice

scholarly journals miR-125-chinmo pathway regulates dietary restriction dependent enhancement of lifespan in Drosophila

2020 ◽  
Author(s):  
Manish Pandey ◽  
Sakshi Bansal ◽  
Sudipta Bar ◽  
Nicholas S. Sokol ◽  
Jason M. Tennessen ◽  
...  
Keyword(s):  
Dietary Restriction ◽  
Healthy Aging ◽  
Fat Body ◽  
Late Onset ◽  
Functional Characterization ◽  
Drug Candidates ◽  
Downstream Effectors ◽  
Processing Factors

AbstractDietary restriction (DR) extends healthy lifespan in diverse species. Age and nutrient-related changes in the abundance of microRNAs (miRNAs) and their processing factors have been linked to organismal longevity. However, the mechanisms by which they modulate lifespan and the tissue-specific role of miRNA mediated networks in DR dependent enhancement of lifespan remains largely unexplored. We show that two neuronally enriched and highly conserved microRNAs, miR-125 and let-7 mediate the DR response in Drosophila melanogaster. Functional characterization of miR-125 demonstrates its role in neurons while its target chinmo acts both in neurons and the fat body to modulate fat metabolism and longevity. Proteomic analysis revealed that Chinmo exerts its DR effects by regulating expression of FATP, CG2017, CG9577, CG17554, CG5009, CG8778, CG9527 and FASN1. Our findings identify miR-125 as a conserved effector of DR pathway and open up the avenue for this small RNA molecule and its downstream effectors to be considered as potential drug candidates for treatment of late-onset diseases and biomarkers for healthy aging in humans.

Influences of Dietary Restriction on Immunity to Influenza in Aged Mice

1991 ◽  
Vol 46 (4) ◽  
pp. B142-B147 ◽  
Author(s):  
R. B. Effros ◽  
R. L. Walford ◽  
R. Weindruch ◽  
C. Mitcheltree
Keyword(s):  
Dietary Restriction ◽  
Aged Mice

scholarly journals Late-onset intermittent fasting dietary restriction as a potential intervention to retard age-associated brain function impairments in male rats

AGE ◽  
2011 ◽  
Vol 34 (4) ◽  
pp. 917-933 ◽  
Author(s):  
Rumani Singh ◽  
Dinesh Lakhanpal ◽  
Sushil Kumar ◽  
Sandeep Sharma ◽  
Hardeep Kataria ◽  
...  
Keyword(s):  
Dietary Restriction ◽  
Brain Function ◽  
Late Onset ◽  
Male Rats ◽  
Intermittent Fasting ◽  
Potential Intervention

scholarly journals Expression of WIPI2B counteracts age-related decline in autophagosome biogenesis in neurons

eLife ◽  
2019 ◽  
Vol 8 ◽  
Author(s):  
Andrea KH Stavoe ◽  
Pallavi P Gopal ◽  
Andrea Gubas ◽  
Sharon A Tooze ◽  
Erika LF Holzbaur
Keyword(s):  
Late Onset ◽  
Autophagosome Formation ◽  
Phosphorylation State ◽  
Aged Mice ◽  
Age Related ◽  
Parkinson’S Diseases ◽  
Morphological Defects ◽  
Shared Risk ◽  
Lateral Sclerosis ◽  
Novel Therapeutic

Autophagy defects are implicated in multiple late-onset neurodegenerative diseases including Amyotrophic Lateral Sclerosis (ALS) and Alzheimer’s, Huntington’s, and Parkinson’s diseases. Since aging is the most common shared risk factor in neurodegeneration, we assessed rates of autophagy in mammalian neurons during aging. We identified a significant decrease in the rate of constitutive autophagosome biogenesis during aging and observed pronounced morphological defects in autophagosomes in neurons from aged mice. While early stages of autophagosome formation were unaffected, we detected the frequent production of stalled LC3B-negative isolation membranes in neurons from aged mice. These stalled structures recruited the majority of the autophagy machinery, but failed to develop into LC3B-positive autophagosomes. Importantly, ectopically expressing WIPI2B effectively restored autophagosome biogenesis in aged neurons. This rescue is dependent on the phosphorylation state of WIPI2B at the isolation membrane, suggesting a novel therapeutic target in age-associated neurodegeneration.

scholarly journals An Investigation of the Effects of Late-Onset Dietary Restriction on Prostate Cancer Development in the TRAMP Mouse

2005 ◽  
Vol 33 (3) ◽  
pp. 386-397 ◽  
Author(s):  
Andrew W. Suttie ◽  
Gregg E. Dinse ◽  
Abraham Nyska ◽  
Glenda J. Moser ◽  
Thomas L. Goldsworthy ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Dietary Restriction ◽  
Late Onset ◽  
Cancer Development ◽  
Tramp Mouse ◽  
Prostate Cancer Development
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