scholarly journals Normal number constructions for Cantor series with slowly growing bases

2016 ◽  
Vol 66 (2) ◽  
pp. 465-480
Author(s):  
Dylan Airey ◽  
Bill Mance ◽  
Joseph Vandehey
Keyword(s):  
Normal Number ◽  
Cantor Series

Why Do We Need New Markers for Male Hypogonadism and How Seminal Proteomics Might Solve the Problem?

2020 ◽  
Vol 27 (12) ◽  
pp. 1186-1191
Author(s):  
Giuseppe Grande ◽  
Domenico Milardi ◽  
Silvia Baroni ◽  
Andrea Urbani ◽  
Alfredo Pontecorvi
Keyword(s):  
Serum Testosterone ◽  
Clinical Syndrome ◽  
Testosterone Replacement ◽  
Total Testosterone ◽  
Male Hypogonadism ◽  
Grey Zone ◽  
Testosterone Levels ◽  
Normal Number ◽  
Replacement Treatment

Male hypogonadism is “a clinical syndrome that results from failure of the testis to produce physiological concentrations of testosterone and/or a normal number of spermatozoa due to pathology at one or more levels of the hypothalamic– pituitary–testicular axis”. The diagnostic protocol of male hypogonadism includes accurate medical history, physical exam, as well as hormone assays and instrumental evaluation. Basal hormonal evaluation of serum testosterone, LH, and FSH is important in the evaluation of diseases of the hypothalamus-pituitary-testis axis. Total testosterone levels < 8 nmol/l profoundly suggest the diagnosis of hypogonadism. An inadequate androgen status is moreover possible if the total testosterone levels are 8-12 nmol/L. In this “grey zone” the diagnosis of hypogonadism is debated and the appropriateness for treating these patients with testosterone should be fostered by symptoms, although often non-specific. Up to now, no markers of androgen tissue action can be used in clinical practice. The identification of markers of androgens action might be useful in supporting diagnosis, Testosterone Replacement Treatment (TRT) and clinical follow-up. The aim of this review is to analyze the main findings of recent studies in the field of discovering putative diagnostic markers of male hypogonadism in seminal plasma by proteomic techniques. The identified proteins might represent a “molecular androtest” useful as a seminal fingerprint of male hypogonadism, for the diagnosis of patients with moderate grades of testosterone reduction and in the follow-up of testosterone replacement treatment.

scholarly journals XVII. On the atomic weight of glucinum (Beryllium)

1883 ◽  
Vol 174 ◽  
pp. 601-613
Keyword(s):  
Specific Heat ◽  
Volatile Compound ◽  
Atomic Weight ◽  
Normal Number ◽  
Vapour Density ◽  
Atomic Heat ◽  
Lothar Meyer ◽  
Free Metal

I. Introductory. Ever since the discovery of glucinum by Vauquelin, in 1798, its atomic weight has been a disputed matter amongst chemists. Its discoverer considered that its oxide was a monoide, an opinion which was however strongly opposed by Berzelius, who wrote the oxide Gl 2 O 3 and the atomic weight 13⋅7 (O=16). The researches of Awdejew and Debrayt again turned the scale in favour of the earlier view, and as an atomic weight of 9⋅2 suited the properties of the metal in the tables of periodicy constructed by MM. Mendeleef and Lothar Meyer, this atomic weight has, up to quite recently, been generally accepted by chemists. As a welcome confirmation to this came a determination of the specific heat of the metal by Professor E. Reynolds, J who found that for its atomic heat to be near the normal number 6⋅0, its atomic weight must be 9⋅2 and not 13⋅8. Almost immediately afterwards a second determination of the specific heat was made by MM. Nilson and Petterson, who, however, obtained a result agreeing not with the lower atomic weight hut with the higher. The reasons for these conflicting opinions are to be found—first, in the anomalous position of glucinum among the elements; secondly, in the difficulties which surround the preparation of even small quantities of the free metal in a tolerably pure condition; and thirdly, in the fact that no volatile compound of glucinum is known of which the vapour density might be easily determined.

A STUDY ON THE CLINICAL AND SUB-CLINICAL FEATURES OF BACTERIAL SKIN INFECTIONS

2020 ◽  
pp. 56-61
Author(s):  
Anh Mai Ba Hoang ◽  
Phuong Nguyen Thi Thanh ◽  
My Nguyen Thi Tra ◽  
Nguyen Le Thi Cao ◽  
Nam Tran Ngoc Khanh
Keyword(s):  
Systemic Effect ◽  
High Rate ◽  
Skin Infections ◽  
Age Group ◽  
Normal Number ◽  
Dermatology Clinic ◽  
Functional Symptoms ◽  
Common Skin ◽  
Keywords Infection ◽  
Bacterial Skin Infections

Background: Bacterial skin infections are common due to the bacteral invasion into the skin and cause a variety of clinical manifestation. In order to assess the characteristics of this group, we conducted this study to evaluate the clinical and main subclinical features. Methods: A total of 95 patients were diagnosed with bacterial skin infections at Dermatology Clinic of Hue University of Medicine and Pharmacy Hospital from June 2015 to May 2016, of which 34 patients had some tests and 19 patients had samples for culture. Results: The age group of 16 - 30 years old was the most popular: 50.5%; High rate of patients came for consultation in winter (49.5%), most patients had no fever. For functional symptoms, pain accounted for the highest proportion: 71.6%. The most common skin lesion was nodule: 38.8%, the lower extremities were the most common position: 38.9%. Furuncle had the highest incidence: 45.3%. For main laboratory tests, most patients had a normal number of leucocyte: 71.4%; ESR increased by two times accounting for a rate of 20.6%; culture results showed Staphylococcus aureus being a highest percentage: 57.9%. Conclusion: Most skin infections localized and were less systemic effect, the most common agent was S. aureus. Keywords: infection, bacteria, skin, fever, S. aureus

scholarly journals Distinct roles for antiparallel microtubule pairing and overlap during early spindle assembly

2013 ◽  
Vol 24 (20) ◽  
pp. 3238-3250 ◽  
Author(s):  
Elena Nazarova ◽  
Eileen O'Toole ◽  
Susi Kaitna ◽  
Paul Francois ◽  
Mark Winey ◽  
...  
Keyword(s):  
Electron Tomography ◽  
Dynamical Behavior ◽  
Three Dimensional ◽  
Spindle Assembly ◽  
Intermediate Step ◽  
High Angle ◽  
Normal Number ◽  
Spindle Poles ◽  
Evolutionarily Conserved ◽  
Microtubule Formation

During spindle assembly, microtubules may attach to kinetochores or pair to form antiparallel pairs or interpolar microtubules, which span the two spindle poles and contribute to mitotic pole separation and chromosome segregation. Events in the specification of the interpolar microtubules are poorly understood. Using three-dimensional electron tomography and analysis of spindle dynamical behavior in living cells, we investigated the process of spindle assembly. Unexpectedly, we found that the phosphorylation state of an evolutionarily conserved Cdk1 site (S360) in γ-tubulin is correlated with the number and organization of interpolar microtubules. Mimicking S360 phosphorylation (S360D) results in bipolar spindles with a normal number of microtubules but lacking interpolar microtubules. Inhibiting S360 phosphorylation (S360A) results in spindles with interpolar microtubules and high-angle, antiparallel microtubule pairs. The latter are also detected in wild-type spindles <1 μm in length, suggesting that high-angle microtubule pairing represents an intermediate step in interpolar microtubule formation. Correlation of spindle architecture with dynamical behavior suggests that microtubule pairing is sufficient to separate the spindle poles, whereas interpolar microtubules maintain the velocity of pole displacement during early spindle assembly. Our findings suggest that the number of interpolar microtubules formed during spindle assembly is controlled in part through activities at the spindle poles.

scholarly journals THE BLOOD PLATELETS IN PNEUMOCOCCUS INFECTIONS

1924 ◽  
Vol 40 (4) ◽  
pp. 553-565 ◽  
Author(s):  
Hobart A. Reimann
Keyword(s):  
Platelet Count ◽  
Intravenous Injection ◽  
Blood Platelets ◽  
Lobar Pneumonia ◽  
Normal Number

1. A study was made of the behavior of the blood platelets during the course of pneumonia in man, as also in several rabbits experimentally infected with pneumococci. 2. The number of platelets begins to diminish after the infection has become established. A thrombopenia occurs during the febrile period. Immediately following the onset of the crisis in lobar pneumonia or after the temperature begins to fall by lysis, the platelets begin gradually to increase in number. In the postfebrile period, the platelet count increases until the normal number is greatly exceeded, and there is a return to the normal number only after about 2 weeks. 3. Sequelæ, characterized by fever, following pneumonia are accompanied by a renewed diminution in the number of platelets. After subsidence of the temperature their number usually increases until the normal is again exceeded. 4. The platelets in general are smaller and contain more granules during the thrombopenic stage of pneumonia. 5. Intravenous injection of antipneumococcus serum during pneumonia ordinarily produces no variation in the number of platelets.

scholarly journals On the Cantor series

1968 ◽  
Vol 18 (1) ◽  
pp. 25-56 ◽  
Author(s):  
Tibor Šalát
Keyword(s):  
Cantor Series

scholarly journals DESCRIPTIVE COMPLEXITY IN CANTOR SERIES

2021 ◽  
pp. 1-22
Author(s):  
DYLAN AIREY ◽  
STEVE JACKSON ◽  
BILL MANCE
Keyword(s):  
Descriptive Complexity ◽  
Cantor Series

scholarly journals A human cancer cell line initiates DNA replication normally in the absence of ORC5 and ORC2 proteins

2020 ◽  
Vol 295 (50) ◽  
pp. 16949-16959
Author(s):  
Etsuko Shibata ◽  
Anindya Dutta
Keyword(s):  
Dna Replication ◽  
Cancer Cells ◽  
Cell Lines ◽  
Cancer Cell ◽  
Origin Recognition Complex ◽  
Human Cancer ◽  
Cancer Cell Line ◽  
Aaa Atpase ◽  
Normal Number ◽  
Mutant Cells

The origin recognition complex (ORC), composed of six subunits, ORC1–6, binds to origins of replication as a ring-shaped heterohexameric ATPase that is believed to be essential to recruit and load MCM2–7, the minichromosome maintenance protein complex, around DNA and initiate DNA replication. We previously reported the creation of viable cancer cell lines that lacked detectable ORC1 or ORC2 protein without a reduction in the number of origins firing. Here, using CRISPR-Cas9–mediated mutations, we report that human HCT116 colon cancer cells also survive when ORC5 protein expression is abolished via a mutation in the initiator ATG of the ORC5 gene. Even if an internal methionine is used to produce an undetectable, N terminally deleted ORC5, the protein would lack 80% of the AAA+ ATPase domain, including the Walker A motif. The ORC5-depleted cells show normal chromatin binding of MCM2–7 and initiate replication from a similar number of origins as WT cells. In addition, we introduced a second mutation in ORC2 in the ORC5 mutant cells, rendering both ORC5 and ORC2 proteins undetectable in the same cells and destabilizing the ORC1, ORC3, and ORC4 proteins. Yet the double mutant cells grow, recruit MCM2–7 normally to chromatin, and initiate DNA replication with normal number of origins. Thus, in these selected cancer cells, either a crippled ORC lacking ORC2 and ORC5 and present at minimal levels on the chromatin can recruit and load enough MCM2–7 to initiate DNA replication, or human cell lines can sometimes recruit MCM2–7 to origins independent of ORC.

THE NORMAL NUMBER OF EOSINOPHIL CELLS IN THE BLOOD

Allergy ◽  
1958 ◽  
Vol 12 (2-3) ◽  
pp. 139-141 ◽  
Author(s):  
K. H. BAAØE
Keyword(s):  
Normal Number

Prenatal and postnatal requirements of NT-3 for sympathetic neuroblast survival and innervation of specific targets

Development ◽  
1996 ◽  
Vol 122 (2) ◽  
pp. 491-500 ◽  
Author(s):  
W.M. ElShamy ◽  
S. Linnarsson ◽  
K.F. Lee ◽  
R. Jaenisch ◽  
P. Ernfors
Keyword(s):  
Pineal Gland ◽  
Internal Carotid ◽  
Sympathetic Neurons ◽  
Sympathetic Innervation ◽  
Mutant Mice ◽  
Normal Complement ◽  
Normal Number ◽  
Neurotrophin 3 ◽  
Cervical Ganglion ◽  
Functional Copy

Postnatal homozygous neurotrophin-3 mutant mice display a loss of about half the sympathetic superior cervical ganglion (SCG) neurons (Ernfors, P., Lee, K.-F., Kucera, J. and Jaenisch, R. (1994a) Cell 77, 503–512; Farinas, I., Jones, K. R., Backus, C., Wang, X. Y. and Reichardt, L. F. (1994) Nature 369, 658–661). We found that this loss is caused by excessive apoptosis of sympathetic neuroblasts leading to a failure to generate a normal number of neurons during neurogenesis. NT-3 was also found to be required postnatally. In Nt-3−/− mice, sympathetic fibers failed to invade pineal gland and external ear postnatally; whereas other targets of the external and internal carotid nerves, including the submandibular gland and the iris, displayed a normal complement of sympathetic innervation. Sympathetic fibers of mice carrying one functional copy of the Nt-3 gene (Nt-3+/− mice) invaded the pineal gland, but failed to branch and form a ground plexus. Cultured neonatal sympathetic neurons responded to NT-3 by neurite outgrowth and mRNA upregulation of the NT-3 receptor, trkC. Exogenously administered NT-3 promoted sympathetic growth and rescued the sympathetic target deficit of the mutant mice. We conclude that NT-3 is required for the survival of sympathetic neuroblasts during neurogenesis and for sympathetic innervation and branching in specific targets after birth.

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