scholarly journals Prevention of NSAID-Enteropathy: A Soluble Problem?

2015 ◽  
Vol 61 (1) ◽  
pp. 1-3 ◽  
Author(s):  
John L. Wallace
Keyword(s):  
Nsaid Enteropathy ◽  
Soluble Problem

NSAID enteropathy detection by small bowel capsule endoscopy

2011 ◽  
Vol 49 (05) ◽  
Author(s):  
V Kovács ◽  
M Szalai ◽  
G Kiss ◽  
H Regőczi ◽  
I Rácz
Keyword(s):  
Small Bowel ◽  
Capsule Endoscopy ◽  
Nsaid Enteropathy

scholarly journals Glycomacropeptide Ameliorates Indomethacin-Induced Enteropathy in Rats by Modifying Intestinal Inflammation and Oxidative Stress

Molecules ◽  
2020 ◽  
Vol 25 (10) ◽  
pp. 2351 ◽  
Author(s):  
Daniel Cervantes-García ◽  
Armida I. Bahena-Delgado ◽  
Mariela Jiménez ◽  
Laura E. Córdova-Dávalos ◽  
Vanessa Ruiz-Esparza Palacios ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Intestinal Inflammation ◽  
Biological Activities ◽  
Antioxidant Properties ◽  
Lipid Hydroperoxide ◽  
Neutrophil Infiltration ◽  
Clinical Problem ◽  
Intestinal Damage ◽  
Nsaid Enteropathy ◽  
Anti Inflammatory

Nonsteroidal anti-inflammatory drug (NSAID)-induced enteropathy is considered a serious and increasing clinical problem without available treatment. Glycomacropeptide (GMP) is a 64-amino acid peptide derived from milk κ-casein with numerous biological activities. The aim of this study was to investigate the protective effect of GMP on NSAID enteropathy in rats. Enteropathy was induced by seven days oral indomethacin administration. Rats were orally GMP treated from seven days previous and during the establishment of the enteropathy model. Changes in metabolism, hematological and biochemical blood alterations, intestinal inflammation and oxidative damage were analyzed. Integrity barrier markers, macroscopic intestinal damage and survival rate were also evaluated. GMP treatment prevented anorexia and weight loss in animals. Furthermore, prophylaxis with GMP ameliorated the decline in hemoglobin, hematocrit, albumin and total protein levels. The treatment had no therapeutic efficacy on the decrease of occludin and mucin (MUC)-2 expression in intestinal tissue. However, GMP markedly decreased neutrophil infiltration, and CXCL1, interleukin-1β and inducible nitric oxide synthase expression. Nitric oxide production and lipid hydroperoxide level in the small intestine were also diminished. These beneficial effects were mirrored by preventing ulcer development and increasing animal survival. These results suggest that GMP may protect against NSAID enteropathy through anti-inflammatory and antioxidant properties.

Helplessness in the Rat: Interfering Response or Motivational/Cognitive Deficit?

1978 ◽  
Vol 47 (3_suppl) ◽  
pp. 1059-1068 ◽  
Author(s):  
G. P. Mullins ◽  
A. H. Winefield
Keyword(s):  
Discrimination Learning ◽  
Learned Helplessness ◽  
Visual Discrimination ◽  
Cognitive Deficit ◽  
Prior Experience ◽  
Visual Discrimination Learning ◽  
Position Response ◽  
Soluble Problem

An experiment showed that experience with an insoluble problem interfered with subsequent visual discrimination learning. Prior experience with a soluble problem significantly reduced the deleterious effects of the insoluble problem but this ‘immunization’ did not benefit subjects which were able to develop an incompatible position response in the insoluble problem. Implications of these and other recent results for the theory of learned helplessness are discussed.

scholarly journals NSAID Gastroenteropathy: Past, Present and Future

1996 ◽  
Vol 10 (7) ◽  
pp. 451-459 ◽  
Author(s):  
John L Wallace
Keyword(s):  
Gastrointestinal Tract ◽  
Inflammatory Disorders ◽  
The Past ◽  
Prostaglandin Synthase ◽  
Nsaid Enteropathy ◽  
The Future ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Identification And Characterization

The toxicity of nonsteroidal anti-inflammatory drugs (NSAIDs) in the gastrointestinal tract continues to be a major limitation to their use in the treatment of inflammatory disorders. Better understanding of the pathogenesis of NSAID enteropathy has facilitated the development of novel NSAIDs that spare the gastrointestinal tract. In particular, identification and characterization of the inducible form of prostaglandin synthase has led to the design of novel NSAIDs that specifically target that enzyme. The pathogenesis of NSAID gastroenteropathy is reviewed, as are the strategies that have been used in the past and are used now to develop NSAIDs that spare the gastrointestinal tract. Also reviewed are the strategies being employed to achieve this goal in the future.

Thymic atrophy in the mouse is a soluble problem of the thymic environment

Vaccine ◽  
2000 ◽  
Vol 18 (16) ◽  
pp. 1629-1637 ◽  
Author(s):  
Richard Aspinall ◽  
Deborah Andrew
Keyword(s):  
Thymic Atrophy ◽  
Soluble Problem

NSAID enteropathy: could probiotics prevent it?

2012 ◽  
Vol 48 (6) ◽  
pp. 689-697 ◽  
Author(s):  
Massimo Montalto ◽  
Antonella Gallo ◽  
Antonio Gasbarrini ◽  
Raffaele Landolfi
Keyword(s):  
Nsaid Enteropathy

scholarly journals A Soluble Problem in Dispersion Theory

1959 ◽  
Vol 113 (6) ◽  
pp. 1663-1669 ◽  
Author(s):  
M. L. Goldberger ◽  
S. B. Treiman
Keyword(s):  
Dispersion Theory ◽  
Soluble Problem

scholarly journals NSAID Enteropathy: A Review of the Disease Entity and Its Distinction from Crohn’s Enteropathy

2019 ◽  
Vol 02 (02) ◽  
pp. 078-086
Author(s):  
Smita Esther Raju ◽  
Rajvinder Singh ◽  
Mahima Raju
Keyword(s):  
Imaging Techniques ◽  
Short Segment ◽  
Cross Sectional ◽  
Protein Losing Enteropathy ◽  
Nsaid Enteropathy ◽  
Small Intestinal Injury ◽  
Cross Sectional Imaging ◽  
Small Intestinal ◽  
High Degree

AbstractNonsteroidal anti-inflammatory drug (NSAID)-induced enteropathy is an increasingly recognized entity. Patients of older age and those suffering from conditions such as arthritis requiring long term NSAIDs are thought to be at greater risk. Introduction of enteroscopic techniques has greatly improved understanding of NSAID-related small intestinal injury. Complementary high-resolution cross-sectional imaging techniques aid in initial evaluation and for exclusion of alternative etiology. Erosions, superficial ulcerations, and short segment strictures are the most commonly described findings. The diagnosis of the condition lies in obtaining relevant history in addition to a high degree of suspicion during investigation of anemia, obscure gastrointestinal bleeding, small bowel obstruction, and protein losing enteropathy. Herein, the authors present a review of pathogenesis and imaging findings of NSAID enteropathy with particular emphasis on distinction from Crohn’s enteropathy.

NSAID enteropathy

1998 ◽  
pp. 75-78
Author(s):  
A. J. Morris
Keyword(s):  
Nsaid Enteropathy
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