scholarly journals Gut Microbiota Composition Before and After Use of Proton Pump Inhibitors

2018 ◽  
Vol 63 (11) ◽  
pp. 2940-2949 ◽  
Author(s):  
Mariko Hojo ◽  
Takashi Asahara ◽  
Akihito Nagahara ◽  
Tsutomu Takeda ◽  
Kohei Matsumoto ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Microbiota Composition ◽  
Before And After ◽  
Gut Microbiota Composition

Changes in the gut microbiota of morbidly obese patients after laparoscopic sleeve gastrectomy

2021 ◽  
Author(s):  
Alev Kural ◽  
Imran Khan ◽  
Hakan Seyit ◽  
Tuba R Caglar ◽  
Pınar Toklu ◽  
...  
Keyword(s):  
Sleeve Gastrectomy ◽  
Gut Microbiota ◽  
Laparoscopic Sleeve Gastrectomy ◽  
Amplicon Sequencing ◽  
Morbidly Obese ◽  
Microbiota Composition ◽  
16S Amplicon Sequencing ◽  
Before And After ◽  
Stool Samples ◽  
Gut Microbiota Composition

Aims: Permanent treatment of morbid obesity with medication or diet is nearly impossible. Laparoscopic sleeve gastrectomy (LSG) is becoming a widely accepted treatment option. This study profiled and compared gut microbiota composition before and after LSG. Methods & results: A total of 54 stool samples were collected from 27 morbidly obese individuals before and after LSG. The gut microbiota was profiled with 16S amplicon sequencing. After LSG, patients demonstrated a significant decrease (p < 0.001) in BMI and an increase in bacterial diversity. An increased Firmicutes/Bacteroidetes ratio was also noticed after LSG. The families Prevotellaceae and Veillonellaceae predominated in preoperative samples but were markedly lowered after LSG. A marked increase in Akkermansia, Alistipes, Streptococcus, Ruminococcus and Parabacteroides was observed after LSG. Conclusion: In addition to lowering BMI, LSG remodeled gut microbiota composition.

scholarly journals The Effects of Non-Nutritive Artificial Sweeteners, Aspartame and Sucralose, on the Gut Microbiome in Healthy Adults: Secondary Outcomes of a Randomized Double-Blinded Crossover Clinical Trial

Nutrients ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 3408
Author(s):  
Samar Y. Ahmad ◽  
James Friel ◽  
Dylan Mackay
Keyword(s):  
Gut Microbiota ◽  
Day Treatment ◽  
Daily Intake ◽  
Short Chain Fatty Acids ◽  
Artificial Sweeteners ◽  
Microbiota Composition ◽  
Faecal Samples ◽  
Before And After ◽  
Double Blinded ◽  
Gut Microbiota Composition

Non-nutritive artificial sweeteners (NNSs) may have the ability to change the gut microbiota, which could potentially alter glucose metabolism. This study aimed to determine the effect of sucralose and aspartame consumption on gut microbiota composition using realistic doses of NNSs. Seventeen healthy participants between the ages of 18 and 45 years who had a body mass index (BMI) of 20–25 were selected. They undertook two 14-day treatment periods separated by a four-week washout period. The sweeteners consumed by each participant consisted of a standardized dose of 14% (0.425 g) of the acceptable daily intake (ADI) for aspartame and 20% (0.136 g) of the ADI for sucralose. Faecal samples collected before and after treatments were analysed for microbiome and short-chain fatty acids (SCFAs). There were no differences in the median relative proportions of the most abundant bacterial taxa (family and genus) before and after treatments with both NNSs. The microbiota community structure also did not show any obvious differences. There were no differences in faecal SCFAs following the consumption of the NNSs. These findings suggest that daily repeated consumption of pure aspartame or sucralose in doses reflective of typical high consumption have minimal effect on gut microbiota composition or SCFA production.

scholarly journals Impact of Proton-Pump Inhibitor Use on Gut Microbiota Composition and Other Markers of Health in Older Adults

2017 ◽  
Vol 4 (suppl_1) ◽  
pp. S234-S234
Author(s):  
Kelly R Reveles ◽  
R Joel Moore ◽  
Reese A Cosimi ◽  
Caitlin N Ryan ◽  
Luisa S Chan ◽  
...  
Keyword(s):  
Older Adults ◽  
Proton Pump Inhibitor ◽  
Gut Microbiota ◽  
Proton Pump ◽  
Microbiota Composition ◽  
Gut Microbiota Composition

scholarly journals Proton pump inhibitor use associated with changes in gut microbiota composition

Gut ◽  
2017 ◽  
Vol 67 (7) ◽  
pp. 1369-1370 ◽  
Author(s):  
Kelly R Reveles ◽  
Caitlin N Ryan ◽  
Luisa Chan ◽  
Reese A Cosimi ◽  
Wanda L Haynes
Keyword(s):  
Proton Pump Inhibitor ◽  
Gut Microbiota ◽  
Proton Pump ◽  
Microbiota Composition ◽  
Gut Microbiota Composition
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