Responses of the hepatic glutathione antioxidant defense system and related gene expression in juvenile common carp after chronic treatment with tributyltin

Ecotoxicology ◽  
2015 ◽  
Vol 24 (3) ◽  
pp. 700-705 ◽  
Author(s):  
Zhi-Hua Li ◽  
Ping Li ◽  
Ze-Chao Shi
2015 ◽  
Vol 30 (6) ◽  
pp. 1465-1465 ◽  
Author(s):  
Juliana Lenzi ◽  
Andre Felipe Rodrigues ◽  
Adriana de Sousa Rós ◽  
Amanda Blanski de Castro ◽  
Daniela Delwing de Lima ◽  
...  

2019 ◽  
Vol 195 (1) ◽  
pp. 135-141 ◽  
Author(s):  
Enver Fehim Kocpinar ◽  
Nurdan Gonul Baltaci ◽  
Hamid Ceylan ◽  
Seyda Nur Kalin ◽  
Orhan Erdogan ◽  
...  

2015 ◽  
Vol 30 (6) ◽  
pp. 1453-1463 ◽  
Author(s):  
Juliana Lenzi ◽  
Andre Felipe Rodrigues ◽  
Adriana de Sousa Rós ◽  
Bianca Blanski de Castro ◽  
Daniela Delwing de Lima ◽  
...  

2010 ◽  
Vol 20 (1) ◽  
pp. 85-89 ◽  
Author(s):  
Carlos E. da Rosa ◽  
Márcio A. Figueiredo ◽  
Carlos F. C. Lanes ◽  
Daniela V. Almeida ◽  
Luis F. Marins

2021 ◽  
Author(s):  
Motoko Nakayama ◽  
Etsuko Ueta ◽  
Mitsuru Yoshida ◽  
Yuri Shimizu ◽  
Reiko Oguchi ◽  
...  

The mechanism of antioxidant defense system is still controversial. As islet β-cell is weak in oxidative condition, that causes diabetes mellitus, therefore, antioxidant defense system of human pancreatic islet derived 1.1B4 cell was analyzed. Cells were exposed to H2O2 and comprehensive gene expression was analyzed by Agilent human microarray. HMOX1 and NR4A3, member of orphan receptor, were up-regulated. Therefore, NR4A3 was knocked down with siRNA, then analyzed gene expression by microarray, and found that the knocked down cells were weak in oxidative stress. HMOX1 expression was strongly inhibited by siRNA of NR4A3, and NR4A3 responsible sequence of aaggtca was found near the HMOX1 gene, suggesting NR4A3 is oxidative stress responsible transcription factor through HMOX1 expression. The expression of CCNE1 and CDK2 was also inhibited by knocked down of NR4A3, it is suggested NR4A3 is also important transcription factor for cell growth regulation.


2018 ◽  
Vol 287 ◽  
pp. 13-19 ◽  
Author(s):  
Magdalena Kimsa-Dudek ◽  
Agnieszka Synowiec-Wojtarowicz ◽  
Małgorzata Derewniuk ◽  
Stanisław Gawron ◽  
Monika Paul-Samojedny ◽  
...  

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