Hepatitis B vaccination in women healthcare workers: A seroepidemiological survey

Before the introduction of universal vaccination, hepatitis B caused high morbidity and mortality, especially among healthcare workers. In the present study, the immune status against hepatitis B was assessed in a cohort of 11,188 students of the degree courses of the School of Medicine of the University of Padua (Italy) who had been subjected to mandatory vaccination in childhood or adolescence and who will be future healthcare workers. The variables that influence the antibody response to vaccination are mainly the age at which the vaccine was administered and sex. If vaccination was administered before one year of age, there is a high probability (around 50%) of having an antibody titer lower than 10 IU/L compared to those vaccinated after one year of age (12.8%). The time between vaccine and analysis is not decisive. Furthermore, female sex, but only if vaccination was administered after one year of age, shows a significant (p = 0.0008) lower percentage of anti-HBs below 10 IU/L and a greater antibody titer (p < 0.0001). In conclusion, the differences related to the age of vaccination induce more doubts than answers. The only plausible hypothesis, in addition to the different immune responses (innate and adaptive), is the type of vaccine. This is not easy to verify because vaccination certificates rarely report it.

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Healthcare workers may need booster hepatitis B vaccination

Inpharma Weekly ◽

10.2165/00128413-200012350-00008 ◽

2000 ◽

Vol &NA; (1235) ◽

pp. 4

Author(s):

&NA;

Keyword(s):

Hepatitis B ◽

Healthcare Workers ◽

Hepatitis B Vaccination

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Immune response to hepatitis B vaccination and factors associated with poor immune response among healthcare workers

Nigerian Journal of Clinical Practice ◽

10.4103/njcp.njcp_187_19 ◽

2021 ◽

Vol 24 (6) ◽

pp. 795

Author(s):

SG Shim ◽

BS Kwan ◽

DH Cho ◽

KM Kim ◽

IS Choi ◽

...

Keyword(s):

Immune Response ◽

Hepatitis B ◽

Healthcare Workers ◽

Hepatitis B Vaccination ◽

Factors Associated

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Prevalence of hepatitis B virus infection and uptake of hepatitis B vaccine among healthcare workers, Makueni County, Kenya 2017

Journal of Public Health ◽

10.1093/pubmed/fdy186 ◽

2018 ◽

Vol 41 (4) ◽

pp. 765-771 ◽

Cited By ~ 3

Author(s):

E N Kisangau ◽

A Awour ◽

B Juma ◽

D Odhiambo ◽

T Muasya ◽

...

Keyword(s):

Hepatitis B Virus ◽

Hepatitis B ◽

Healthcare Workers ◽

Vaccination Status ◽

Hbv Infection ◽

Hepatitis B Vaccination ◽

Infection Prevalence ◽

Similar Data ◽

Factors Associated ◽

B Virus

Abstract Background Hepatitis B virus (HBV) is a vaccine-preventable infection that can spread in healthcare setting. Data on HBV infections and vaccine in African healthcare workers (HCWs) are limited. We estimated HBV infection prevalence, hepatitis B vaccination status and identified factors associated with vaccination in one Kenyan county. Methods Randomly selected HCWs completed a questionnaire about HBV exposure and self-reported immunization histories, and provided blood for testing of selected HBV biomarkers to assess HBV infection and vaccination status: HBV core antibodies (anti-HBc), HBV surface antigen (HBsAg) and HBV surface antibodies (anti-HBs). Prevalence odds ratios (OR) with 95% confidence intervals (95% CI) were calculated to identify factors associated with vaccination. Results Among 312 HCWs surveyed, median age was 31 years (range: 19–67 years). Of 295 blood samples tested, 13 (4%) were anti-HBc and HBsAg-positive evidencing chronic HBV infection; 139 (47%) had protective anti-HBs levels. Although 249 (80%) HCWs received ≥1 HBV vaccine dose, only 119 (48%) received all three recommended doses. Complete vaccination was more likely among those working in hospitals compared to those working in primary healthcare facilities (OR = 2.5; 95% CI: 1.4–4.3). Conclusion We recommend strengthening county HCW vaccination, and collecting similar data nationally to guide HBV prevention and control.

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A STUDY TO ASSESS THE SEROPREVALENCE OF HEPATITIS B AND ANTI HBS ANTIBODY LEVELS AMONGST HEALTH CARE WORKERS AND MEDICAL STUDENTS.

10.36106/ijsr/8002609 ◽

2021 ◽

pp. 84-85

Author(s):

Aditya Rana ◽

Anuradha Sood

Keyword(s):

Medical Students ◽

Hepatitis B ◽

Healthcare Workers ◽

Base Material ◽

Hepatitis B Vaccination ◽

Continuous Exposure ◽

Cross Sectional ◽

Antibody Titres ◽

Antibody Titers ◽

Antibody Levels

Background: Hepatitis B(HBV) is a blood borne virus and it is one of the most important occupational hazards among healthcare workers (HCWs) & Medical students. This study aimed to measure the anti-HBs titres and to assess the seroprevalence of Hepatitis B in HCW and medical students. It was a prospective,descriptive and cross sectional hospital base Material and method: d study. Medical students and healthcare workers who had received all three doses of hepatitis B vaccination were included in the study. A total of 200 subjects , aged between 18 and Result: 62 years were taken. 182 were vaccinated and 18 were unvaccinated. 85 were males and 115 females. Seroprevalence of Hepatitis B was nil. Antibody titres were >100mIU/ml in 51.6% , 10-100mIU/ml in 16.4% & <10 mIU/ml in 31.8% respectively.Negative correlation of decreasing antibiotic titer and age was seen. HCW and medical students are at hi Conclusion: gher risk due to their continuous exposure to blood products. Vaccination should be compulsory to the HCW and medical workers in the institution as Hepatitis B is a preventable disease. Monitoring of antibody titers should be done from time to time to see waning off antibody titers after vaccination

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507 National hepatitis b vaccination policies for healthcare workers in member-states of the european union: an updated overview

10.1136/oemed-2018-icohabstracts.984 ◽

2018 ◽

Author(s):

A de Schryver ◽

T Lambaerts ◽

N Lammertyn

Keyword(s):

European Union ◽

Hepatitis B ◽

Healthcare Workers ◽

Hepatitis B Vaccination ◽

The European Union ◽

Member States

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Prevalence and Risk Factors for Bloodborne Exposure and Infection in Correctional Healthcare Workers

Infection Control and Hospital Epidemiology ◽

10.1086/510813 ◽

2007 ◽

Vol 28 (1) ◽

pp. 24-30 ◽

Cited By ~ 19

Author(s):

Robyn R. M. Gershon ◽

Martin Sherman ◽

Clifford Mitchell ◽

David Vlahov ◽

Melissa J. Erwin ◽

...

Keyword(s):

Risk Factors ◽

Hepatitis C Virus ◽

Hepatitis C ◽

Virus Infection ◽

Hepatitis B ◽

Healthcare Workers ◽

Hepatitis B Vaccination ◽

Hepatitis C Virus Infection ◽

Job Duties ◽

Correctional Healthcare

Objective.To determine the prevalence and risk factors for bloodborne exposure and infection in correctional healthcare workers (CHCWs).Design.Cross-sectional risk assessment study with a confidential questionnaire and serological testing performed during 1999-2000.Setting.Correctional systems in 3 states.Results.Among 310 participating CHCWs, the rate of percutaneous injury (PI) was 32 Pis per 100 person-years overall and 42 Pis per 100 person-years for CHCWs with clinical job duties. Underreporting was common, with only 25 (49%) of 51 Pis formally reported to the administration. Independent risk factors for experiencing PI included being age 45 or older (adjusted odds ratio [aOR], 2.41 (95% confidence interval (CI), 1.31-4.46]) and having job duties that involved needle contact (aOR, 3.70 [95% CI, 1.28-10.63]) or blood contact (aOR, 5.05 [95% CI, 1.45-17.54]). Overall, 222 CHCWs (72%) reported having received a primary hepatitis В vaccination series; of these, 150 (68%) tested positive for anti-hepatitis B surface antigen, with negative results significantly associated with receipt of last dose more than 5 years previously. Serologic markers of hepatitis В virus infection were identified in 31 individuals (10%), and the prevalence of hepatitis B virus infection was 2% (n = 7). The high hepatitis B vaccination rate limited the ability to identify risk factors for infection, but hepatitis C virus infection correlated with community risk factors only.Conclusion.Although the wide coverage with hepatitis B vaccination and the decreasing rate of hepatitis C virus infection in the general population are encouraging, the high rate of exposure in CHCWs and the lack of exposure documentation are concerns. Continued efforts to develop interventions to reduce exposures and encourage reporting should be implemented and evaluated in correctional healthcare settings. These interventions should address infection control barriers unique to the correctional setting.

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