Intrauterine insemination with husband semen: an evaluation of pregnancy rate and factors affecting outcome

ABSTRACT Objectives To determine the predictive factors for pregnancy after stimulated intrauterine insemination (IUI). Materials and methods A retrospective analysis of 136 patients undergoing 443 stimulated IUI cycles was done in an attempt to identify significant variables predictive of treatment success. The primary outcome measures were clinical pregnancy and live birth rates. Predictive factors evaluated were female age, duration of infertility, indication for IUI, number of preovulatory follicles, and postwash total motile fraction (TMF). Results The overall clinical pregnancy rate and live birth rate were 7.2% and 5.1 per cycle respectively. The mean number of IUI cycles per patient was 3.2, the miscarriage rate was 15%, and the multiple pregnancy rate was 3.1%. Among the predictive factors evaluated, female age (age > 37 years; p = 0.039), the duration of infertility (5.36 vs 6.71 years, p = 0.032), and the TMF (between 10 and 20 million, p = 0.003) significantly influenced the clinical pregnancy rate. Conclusion The clinical management of the selected infertile couple should be performed in an expedited manner taking into consideration the age of the woman, etiology, and duration of infertility and motile fraction of sperms. How to cite this article Patel AP, Patel MS, Shah SR, Jani SK. Predictive Factors for Pregnancy after Intrauterine Insemination: A Retrospective Study of Factors Affecting Outcome. J South Asian Feder Obst Gynae 2016;8(2):140-144.

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When is enough enough? Pregnancy rate and cost-effectiveness of three cycles homologous intrauterine insemination (IUI) vs. one cycle mild ovarian stimulation in vitro fertilization (IVF)

10.26226/morressier.573c1513d462b80296c98803 ◽

2016 ◽

Author(s):

Aboubakar Cissé

Keyword(s):

Cost Effectiveness ◽

In Vitro Fertilization ◽

Pregnancy Rate ◽

Ovarian Stimulation ◽

Intrauterine Insemination ◽

Vitro Fertilization ◽

Mild Ovarian Stimulation

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SOME FACTORS AFFECTING PREGNANCY RATE DURING ARTIFICIAL INSEMINATION IN CATTLE

10.36295/asro.2019.220716 ◽

2019 ◽

Vol 22 (07) ◽

pp. 118-122

Author(s):

Haider R. Abbas ◽

Hussein A. Khamees ◽

Jawad K. Taher

Keyword(s):

Pregnancy Rate ◽

Artificial Insemination ◽

Factors Affecting

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Controlled ovarian stimulation should not be preferred for male infertility treated with intrauterine insemination: a retrospective study

Reproductive Biology and Endocrinology ◽

10.1186/s12958-021-00730-3 ◽

2021 ◽

Vol 19 (1) ◽

Author(s):

Yan Tang ◽

Qian-Dong He ◽

Ting-Ting Zhang ◽

Jing-Jing Wang ◽

Si-Chong Huang ◽

...

Keyword(s):

Ectopic Pregnancy ◽

Pregnancy Rate ◽

Ovarian Stimulation ◽

Intrauterine Insemination ◽

Multiple Pregnancy ◽

Clinical Pregnancy ◽

Male Factor Infertility ◽

Male Factor ◽

Ovulatory Follicles ◽

Multiple Pregnancy Rate

Abstract Background Some studies have stated that intrauterine insemination (IUI) with controlled ovarian stimulation (COS) might increase the pregnancy rate, while others suggest that IUI in the natural cycle (NC) should be the first line of treatment. It remains unclear whether it is necessary to use COS at the same time when IUI is applied to treat isolated male factor infertility. Thus, we aimed to investigate efficacy of IUI with COS for isolated male factor infertility. Methods A total of 601 IUI cycles from 307 couples who sought medical care for isolated male factor infertility between January 2010 and February 2020 were divided into two groups: NC-IUI and COS-IUI. The COS-IUI group was further divided into two subgroups according to the number of pre-ovulatory follicles on the day of HCG: cycles with monofollicular development (one follicle group) and cycles with at least two pre-ovulatory follicles (≥ 2 follicles group). The IUI outcomes, including clinical pregnancy, live birth, spontaneous abortion, ectopic pregnancy, and multiple pregnancy rates were compared. Results The clinical pregnancy, live birth, spontaneous abortion, and ectopic pregnancy rates were comparable between the NC-IUI and COS-IUI group. Similar results were also observed among the NC-IUI, one follicle, and ≥ 2 follicles groups. However, with respect to the multiple pregnancy rate, a trend toward higher multiple pregnancy rate was observed in the COS-IUI group compared to the NC-IUI group (8.7% vs. 0, P = 0.091), and a significant difference was found between the NC-IUI and ≥ 2 follicles group (0 vs. 16.7%, P = 0.033). Conclusion In COS cycles, especially in those with at least two pre-ovulatory follicles, the multiple pregnancy rate increased without a substantial gain in overall pregnancy rate; thus, COS should not be preferred in IUI for isolated male factor infertility. If COS is required, one stimulated follicle and one healthy baby should be the goal considering the safety of both mothers and foetuses.

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Factors affecting pregnancy rate following nonsurgical embryo transfer in buffalo (Bubalus bubalis) : A retrospective study

Theriogenology ◽

10.1016/s0093-691x(99)00105-3 ◽

1999 ◽

Vol 52 (1) ◽

pp. 1-10 ◽

Cited By ~ 7

Author(s):

A.K. Misra ◽

M. Mutha Rao ◽

R. Kasiraj ◽

N.S. Ranga Reddy ◽

H.C. Pant

Keyword(s):

Retrospective Study ◽

Pregnancy Rate ◽

Embryo Transfer ◽

Bubalus Bubalis ◽

Factors Affecting

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Evaluation of Endometrial Urocortin Secretion for Prediction of Pregnancy after Intrauterine Insemination

Clinical Chemistry ◽

10.1373/clinchem.2007.094987 ◽

2008 ◽

Vol 54 (2) ◽

pp. 350-355 ◽

Cited By ~ 9

Author(s):

Pasquale Florio ◽

Luca Bruni ◽

Carmen De Falco ◽

Gilda Filardi ◽

Michela Torricelli ◽

...

Keyword(s):

Confidence Interval ◽

Pregnancy Rate ◽

Endometrial Thickness ◽

Intrauterine Insemination ◽

Biological Effects ◽

Unexplained Infertility ◽

Successful Pregnancy ◽

Ultrasound Evaluation ◽

Study Population ◽

Blastocyst Implantation

Abstract Background: Urocortin is a neuropeptide produced by the human endometrium and has biological effects putatively important for promoting blastocyst implantation. We measured urocortin concentrations in samples of endometrial wash fluid collected from women with unexplained infertility who underwent intrauterine insemination (IUI). Methods: Patients 28–42 years of age (n = 71) were consecutively enrolled after a complete clinical evaluation. Endometrial wash fluid was retrieved before IUI, at the time of ultrasound evaluation of endometrial thickness. Urocortin concentrations were assayed with a specific ELISA. Results: After IUI, 28 patients (39%) became pregnant. Urocortin concentrations were significantly higher in women who became pregnant than in those who did not (0.38 μg/L vs 0.13 μg/L, P <0.0001). At a cutoff of 0.321 μg/L, urocortin results were positive in 61% [95% confidence interval (CI), 41%–78%] of women who had successful implantation and negative in 98% (95% CI, 88%–99.6%) of those who did not. The pregnancy rate for women with urocortin concentrations >0.32 μg/L was 94%, which differed significantly (P <0.05) from the overall pregnancy rate of 39% in the study population. Conclusions: Urocortin is measurable in endometrial wash fluid, and its concentrations before IUI are higher in women who subsequently achieve pregnancy. These data suggest that the probability of having a successful pregnancy-producing IUI may be better estimated by measuring urocortin in endometrial wash fluid.

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