Polycaprolactone and poly-β-cyclodextrin polymer blend: a Biopolymers composite film for drug release

2021 ◽  
Author(s):  
Francesca Antonella Sepúlveda ◽  
Julio Sánchez ◽  
Diego P. Oyarzun ◽  
Fidel E. Rodríguez-González ◽  
Alain Tundidor-Camba ◽  
...  
Keyword(s):  
Drug Release ◽  
Composite Film ◽  
Polymer Blend ◽  
Cyclodextrin Polymer

Understanding the Impact of Polymer Ratio and its Concentration on Omeprazole Release from Matrix Tablets: Response Optimization Study

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Tiwari R. ◽  
Tiwari G. ◽  
Wal P. ◽  
Wal A. ◽  
Maurya P.
Keyword(s):  
Drug Release ◽  
Polymer Blend ◽  
Release Profile ◽  
Matrix Tablets ◽  
Drug Release Profile ◽  
Drug Content ◽  
Weight Variation ◽  
Carbopol 934P ◽  
Polymer Ratio

In present study, matrix tablets of Omeprazole (OPZ) were formulated by wet granulation technique using a combination of hydroxyl propyl methyl cellulose (HPMC K15M) and ethyl cellulose (EC) in varying ratios and the effect of polymer ratio as well as their concentration on drug release profile was investigated. Response surface methodology (RSM) was conducted to optimize matrix tablets. Compressed tablets were evaluated for hardness, friability, weight variation, drug content and in vitro dissolution studies. The dissolution study was performed in pH1.2 for the first 2 h and in phosphate buffer (pH 7.4) for another 5 h. The optimized formulation was compared with other formulations using similarity (ƒ2) and dissimilarity factor (ƒ1) test. The results of RSM indicated that both X1 (the blending ratio of HPMC K15M K15M and Carbopol 934P 934P) and X2 (polymer blend concentration)have significant effect on in-vitro drug release profile. Hardness, friability, weight variation and drug content were found to be in desired range. Among different formulations, matrix tablets prepared by HPMC K15M and Carbopol 934P 934P (7:3) with 15% polymer blend concentration displayed 98.85% OPZ release in 7 hr. and release kinetic was higuchi (r 2= 0.9884). Similarity (f2) and dissimilarity (f1) factors demonstrated that the in vitro profiles were not similar. Finally, it was concluded that release rate of OPZ decreased proportionally with increasing polymer ratio (HPMC K15M: Carbopol 934P 934P) and decreasing polymer blend concentration.

Development and characterization of sodium alginate/poly(sodium 4-styrenesulfonate) composite films for release behavior of ciprofloxacin hydrogen chloride monohydrate

2021 ◽  
pp. 096739112199027
Author(s):  
M Sohail Sarwar ◽  
Abdul Ghaffar ◽  
Qingrong Huang
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Composite Film ◽  
Sodium Alginate ◽  
Composite Films ◽  
Simulated Gastric Fluid ◽  
Release Behavior ◽  
Drug Release Behavior ◽  
Model Drug

Biopolymers, in particular polysaccharides, have attracted considerable interest in the field of drug delivery due to their biodegradable and biocompatible nature. This study is focused on the preparation and characterization of drug delivery devices based on sodium alginate (SA) composite films with poly(sodium 4-styrenesulfonate) (PSS). The prepared composite films were characterized for the determination of physiochemical properties, molecular interactions, and drug release behavior. The possible intermolecular hydrogen bonding between SA and PSS was determined by ATR-FTIR spectroscopy. Surface characterization was done using AFM. Polymeric films consisted of pristine SA and PSS exhibited relatively uniform and flat surfaces. However, the composite films showed phase separation that became more prominent as the concentration of PSS in the composite films was increased up to 40% (w/w). The contact angle (CA) values, using deionized water as a function of time (s), were ranging from 74° to 90°, and a decrease in CA (64° to 76°) was recorded for each composite film till 40 s. These CA values revealed that all the composite films were hydrophobic. It was observed that as the concentration of PSS in the films increased, hydrophobicity slightly varied as compared to the blank films of SA and PSS. Maximum CA (89°) was shown by a composite film having SA/PSS (90/10). Ciprofloxacin hydrochloride monohydrate (CPX), a model drug, loaded in a suitable composite film (cross-linked with 0.3 M CaCl2 solution) and drug release was evaluated in pH 1.2 simulated gastric fluid (SGF) and pH 7.4 phosphate buffer saline (PBS) solution. In SGF, around 90% of the model drug was released in 110 min that was approximately 77% in the case of PBS. Therefore, it was concluded that a sustained drug release behavior was exhibited in SGF as compared to PBS solution. These results suggest that these films are a promising and may potentially be subjected to study further their drug delivery behavior in applications like wound dressing. [Formula: see text]

scholarly journals EFFECT OF FISH SCALE COLLAGEN ON SOME CHARACTERISTICS AND DRUG RELEASE OF CARRAGEENAN/COLLAGEN/ALLOPURINOL FILM

2019 ◽  
Vol 57 (3B) ◽  
pp. 1
Author(s):  
Chinh Thuy Nguyen ◽  
Mai Thi Tran ◽  
Manh Quoc Vu ◽  
Tran Thi Thu Nguyen ◽  
Trang Do Mai Tran ◽  
...  
Keyword(s):  
Drug Release ◽  
Composite Film ◽  
Composite Films ◽  
Differential Scanning Calorimetric ◽  
Fish Scale ◽  
Environment Pollution ◽  
Fish Scales ◽  
Fish Processing ◽  
Visible Spectroscopy ◽  
Scanning Electron

ABSTRACT - QMFS2019Collagen from fish is attracting a lot of attention thanks to its high absorbance ability, biocompatibility as well as non-religious obstruction and cheap sources. It could be applied in many fields, for example: food, cosmetic, or biomedicine. Using of collagen also helps to reduce the environment pollution from fish scale waste in fish processing. In this study, collagen extracted from Vietnamese fresh-water tilapia fish scales was used in combination with carrageenan for the improvement of drug release control. The influence of fish scale collagen content on morphology, thermal behavior and drug release from carrageenan/collagen/allopurinol composite film was evaluated by methods such as field emission scanning electron microscopy (FESEM), differential scanning calorimetric (DSC) and ultraviolet-visible spectroscopy (UV-Vis). From the DSC data, FESEM analysis and drug release of carrageenan/collagen/allopurinol composite films, the most suitable collagen in composite film is 5 wt.%.

Temperature Dependence of Single Chain Properties in a Binary Polymer Blend

1996 ◽  
Vol 6 (2) ◽  
pp. 187-194 ◽  
Author(s):  
M. Müller ◽  
K. Binder
Keyword(s):  
Temperature Dependence ◽  
Polymer Blend ◽  
Single Chain ◽  
Binary Polymer

Formulation, Design and Development of Niosome Based Topical Gel for Skin Cancer

2017 ◽  
Vol 2 (3) ◽  
Keyword(s):  
Skin Cancer ◽  
Drug Release ◽  
Hemorrhagic Cystitis ◽  
The Body ◽  
Cancer Drug ◽  
Inversion Method ◽  
Body Parts ◽  
Basal Cells ◽  
Formulation Design ◽  
Topical Gel

Melanoma is the most dangerous type of skin cancer in which mostly damaged unpaired DNA starts mutating abnormally and staged an unprecedented proliferation of epithelial skin to form a malignant tumor. In epidemics of skin, pigment-forming melanocytes of basal cells start depleting and form uneven black or brown moles. Melanoma can further spread all over the body parts and could become hard to detect. In USA Melanoma kills an estimated 10,130 people annually. This challenge can be succumbed by using the certain anti-cancer drug. In this study design, cyclophosphamide were used as a model drug. But it has own limitation like mild to moderate use may cause severe cytopenia, hemorrhagic cystitis, neutropenia, alopecia and GI disturbance. This is a promising challenge, which is caused due to the increasing in plasma drug concentration above therapeutic level and due to no rate limiting steps involved in formulation design. In this study, we tried to modify drug release up to threefold and extended the release of drug by preparing and designing niosome based topical gel. In the presence of Dichloromethane, Span60 and cholesterol, the initial niosomes were prepared using vacuum evaporator. The optimum percentage drug entrapment efficacy, zeta potential, particle size was found to be 72.16%, 6.19mV, 1.67µm.Prepared niosomes were further characterized using TEM analyzer. The optimum batch of niosomes was selected and incorporated into topical gel preparation. Cold inversion method and Poloxamer -188 and HPMC as core polymers, were used to prepare cyclophosphamide niosome based topical gel. The formula was designed using Design expert 7.0.0 software and Box-Behnken Design model was selected. Almost all the evaluation parameters were studied and reported. The MTT shows good % cell growth inhibition by prepared niosome based gel against of A375 cell line. The drug release was extended up to 20th hours. Further as per ICH Q1A (R2), guideline 6 month stability studies were performed. The results were satisfactory and indicating a good formulation approach design was achieved for Melanoma treatment.

Effects of release modifier on Carvedilol release from Kollidon SR based matrix

2012 ◽  
Vol 1 (8) ◽  
pp. 186 ◽  
Author(s):  
Urmi Das ◽  
Mohammad Salim Hossain
Keyword(s):  
Drug Release ◽  
Sustained Release ◽  
Microcrystalline Cellulose ◽  
Matrix Tablets ◽  
Dissolution Time ◽  
Release Mechanism ◽  
Matrix Tablet ◽  
Weight Variation ◽  
The Matrix ◽  
Tablet Formulations

<p>Sustained release Carvedilol matrix tablets constituting Kollidon SR were developed in this study in an attempt to investigate the effect of release modifiers on the release profile of Carvedilol from matrix. Three matrix tablet formulations were prepared by direct compression of Kollidon SR in combination with release modifier (HPMC and Microcrystalline Cellulose) and magnesium stearate. Tablets containing only Kollidon SR with the active ingredient demonstrated a rapid rate of drug release. Incorporation of HPMC in the matrix tablet prolonged the release of drug but incorporation of Microcrystalline Cellulose showed superimposable release pattern with an initial burst effect as confirmed by mean dissolution time and Higuchi release rate data. After 7 hours of dissolution, Carvedilol release from the matrix systems were 91.42%, 83.41%, from formulation F1 and F2 respectively. Formulation F3 exhibited 100 % release at 4 hours. All the tablet formulations showed acceptable pharmaco-technical properties and complied with the in-house specifications for tablet weight variation, friability, hardness, thickness, and diameter. Prepared tablets also showed sustained release property for carvedilol. The drug release mechanism from the matrix tablets of F1 and F2 was found to be followed by Fickian and F3 by Non-Fickian mechanism.</p><p>DOI: <a href="http://dx.doi.org/10.3329/icpj.v1i8.11095">http://dx.doi.org/10.3329/icpj.v1i8.11095</a></p> <p>International Current Pharmaceutical Journal 2012, 1(8): 186-192</p>

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