scholarly journals Bovine serum albumin nanoparticles as controlled release carrier for local drug delivery to the inner ear

2014 ◽  
Vol 9 (1) ◽  
Author(s):  
Zhan Yu ◽  
Min Yu ◽  
Zhibao Zhang ◽  
Ge Hong ◽  
Qingqing Xiong
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Inner Ear ◽  
Bovine Serum ◽  
Local Drug Delivery ◽  
Albumin Nanoparticles

Biotin-modified bovine serum albumin nanoparticles as a potential drug delivery system for paclitaxel

2019 ◽  
Vol 54 (11) ◽  
pp. 8613-8626 ◽  
Author(s):  
Danfeng Wang ◽  
Na Liang ◽  
Yoshiaki Kawashima ◽  
Fude Cui ◽  
Pengfei Yan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Drug Delivery System ◽  
Delivery System ◽  
Bovine Serum ◽  
Potential Drug ◽  
Albumin Nanoparticles

PREPARATION OF CINOBUFAGIN-LOADED BOVINE SERUM ALBUMIN NANOPARTICLES FOR HEPATOCARCINOMA THERAPY

NANO ◽  
2009 ◽  
Vol 04 (01) ◽  
pp. 47-54 ◽  
Author(s):  
YONG-HUA SU ◽  
JIAN-GUO ZHANG ◽  
JIE SHEN ◽  
FENG-QIAN LI ◽  
HUA SU ◽  
...  
Keyword(s):  
Controlled Release ◽  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Drug Loading ◽  
Aqueous Media ◽  
Lethal Dose ◽  
Albumin Nanoparticles ◽  
Transplantation Tumors

Cinobufagin-loaded bovine serum albumin nanoparticles were prepared for treating hepatocellular carcinoma. In this report, cinobufagin-bovine serum albumin-nanoparticles (Cino-BSA-NP) were prepared by an aqueous desolvation process. The physicochemical properties, toxicity, and cancer-related applications of Cino-BSA-NP were investigated. Cino-BSA-NP had a uniform spherical morphology with a particle size in the range of 50–240 nm and an average size of 86.3 nm. The zeta potential of the nanoparticles was -49 mV. The overall embedding ratio was 79.5% and the drug loading was 24.1%. Cino-BSA-NP gave cinobufagin release of up to 53.5% within 3 h, followed by slower controlled release. Cino-BSA-NP inhibited growth of hepatocarcinoma cells in vitro to a similar extent as free cinobufagin, but with a much higher median lethal dose (LD50). Hepatic histomorphological changes indicated that hepatic damage was much less severe with Cino-BSA-NP than with free cinobufagin (2.19 mg/kg). The survival time of nude mice with orthotopic transplantation tumors treated with Cino-BSA-NP was prolonged significantly. The results confirm that Cino-BSA-NP renders cinobufagin completely dispersible in aqueous media, meeting the key requirements for intravenous injection, and show controlled release, thus significantly improving cinobufagin's antitumor activity while reducing its side effects.

Fatty-Amine-Conjugated Cationic Bovine Serum Albumin Nanoparticles for Target-Specific Hydrophobic Drug Delivery

2019 ◽  
Vol 2 (6) ◽  
pp. 3671-3683 ◽  
Author(s):  
Abhishek Saha ◽  
Nirmalya Pradhan ◽  
Soumya Chatterjee ◽  
Rakesh Kumar Singh ◽  
Vishal Trivedi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Hydrophobic Drug ◽  
Fatty Amine ◽  
Albumin Nanoparticles
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