Fabrication of nano-macroporous glass–ceramic bioscaffold with a water soluble pore former

2011 ◽  
Vol 23 (2) ◽  
pp. 307-314 ◽  
Author(s):  
H. M. Moawad ◽  
H. Jain
Keyword(s):  
Glass Ceramic ◽  
Water Soluble ◽  
Pore Former ◽  
Macroporous Glass

Preparation of Macroporous Glass-Ceramic Composites Containing β-TCP

2006 ◽  
Vol 11-12 ◽  
pp. 223-226
Author(s):  
Akiko Obata ◽  
Megumi Sasaki ◽  
Toshihiro Kasuga
Keyword(s):  
Tissue Engineering ◽  
Compressive Strength ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Glass Ceramic ◽  
Tricalcium Phosphate ◽  
Ceramic Composites ◽  
Calcium Pyrophosphate ◽  
Macroporous Glass ◽  
Glass Powders

A macroporous phosphate invert glass ceramic (PIGC) was prepared by dipping polymer sponges in the powder-slurry of the mother glass with a composition of 60CaO-30P2O-3TiO2- 7Na2O in mol%, and subsequent burning off the sponge at 850°C for 1 hr. The macroporous PIGC consists predominantly of ß-tricalcium phosphate (β-TCP) and ß-calcium pyrophosphate, and it has macropores of 500 μm in diameter and porosity of 83 %. Its compressive strength was estimated to be 160 kPa. The PIGC composite containing a large amount of β-TCP was also prepared by heating the mixture of Ca(OH)2 with the mother glass powders of the PIGC. Solubility of the composite was higher than PIGC. The macroporous PIGC and PIGC composite were expected to be applicable in high resorbable scaffolds for bone tissue engineering.

scholarly journals Glass-Ceramic Scaffolds and Shock Waves Effect on Cells Migration

2007 ◽  
Vol 361-363 ◽  
pp. 233-236 ◽  
Author(s):  
Chiara Vitale-Brovarone ◽  
Francesco Baino ◽  
Germana Martinasso ◽  
Rosangela Canuto ◽  
Francesco Bassi ◽  
...  
Keyword(s):  
Shock Waves ◽  
Glass Ceramic ◽  
Bone Grafting ◽  
Complete Characterization ◽  
Human Osteoblasts ◽  
Replication Method ◽  
And Shock Waves ◽  
Macroporous Glass

Glass-ceramic scaffolds for bone grafting have been prepared using the sponge replication method and a highly bioactive silica based glass belonging to the system SiO2-P2O5- CaO-MgO-Na2O-K2O (CEL2). The parameters for the sponge impregnation were optimized in order to obtain a continuous coating of the polymeric skeleton which will lead, after the polymeric phase removal, to a resistant macroporous glass-ceramic template. A complete characterization was carried out on the obtained scaffold in order to assess its morphology and specifically its porosity and the degree of pores interconnection. A human osteoblasts cells line (MG-63) was cultured onto the scaffold and the effect of stimulation with shock waves on the cell ability of colonizing the scaffold was investigated.

Effects of polyvinylpyrrolidone both as a binder and pore-former on the release of sparingly water-soluble topiramate from ethylcellulose coated pellets

2014 ◽  
Vol 465 (1-2) ◽  
pp. 187-196 ◽  
Author(s):  
Meiyan Yang ◽  
Si Xie ◽  
Qiu Li ◽  
Yuli Wang ◽  
Xinyi Chang ◽  
...  
Keyword(s):  
Water Soluble ◽  
Pore Former

Floating Alginate Beads as Carriers for Self-Emulsifying System Containing Tetrahydrocurcumin

2012 ◽  
Vol 506 ◽  
pp. 517-520 ◽  
Author(s):  
S. Sriraksa ◽  
N. Sermkaew ◽  
S. Setthacheewakul ◽  
R. Wiwattanapatapee
Keyword(s):  
Oral Delivery ◽  
Aqueous Suspension ◽  
Aqueous Solubility ◽  
Gastric Fluid ◽  
Alginate Beads ◽  
Water Soluble ◽  
Simulated Gastric Fluid ◽  
Pore Former ◽  
Gastric Residence Time

Tetrahydrocurcumin (THC), one of the curcumin metabolites, exhibits pharmacological activities such as antioxidant, anti-inflammatory and anti-carcinogenic properties. However, the pharmacological effect of THC is limited due to its low aqueous solubility. Floating alginate beads containing self-emulsifying drug delivery system (SEDDS) of THC were developed to increase drug solubility and prolong gastric residence time. Use of different weight proportions of sodium alginate (Na-alg.), calcium chloride (CaCl2) and water soluble pore former (Polyvinylalcohol-polyethylene glycol copolymer; Kollicoat® IR) in bead formulations had different effects on the floating abilities and in vitro rate of THC release. The release profile of the optimized THC-SEDDS floating alginate beads (D3) indicated a significant increase in the dissolution rate of THC and provided a controlled release of THC over an 8 h period in a simulated gastric fluid. The release of about 80% of THC from the optimized beads as an o/w microemulsion with a particle size of less than 50 nm, compared to only 30 % by an aqueous suspension from the unformulated THC could be considerable greater absorbed. The self-emulsifying floating alginate beads may provide a useful solid dosage form for oral delivery of THC and other hydrophobic compounds.

Structural Performance Analysis of Hydroxyapatite Scaffolds for Tissue Engineering

2013 ◽  
Author(s):  
Enrique Gallegos-Nieto ◽  
Hugo I. Medellín-Castillo ◽  
Dirk F. de Lange ◽  
Gilberto Mejía-Rodríguez
Keyword(s):  
Mechanical Performance ◽  
Numerical Models ◽  
Experimental Tests ◽  
Theoretical Models ◽  
Water Soluble ◽  
Structural Performance ◽  
Poly Vinyl Alcohol ◽  
Pore Former ◽  
Water Soluble Polymer ◽  
Variable Porosity

The development of hydroxyapatite (HA) scaffolds for tissue regeneration, particularly for bone regeneration, is an alternative to treat bone defects due to cancer, other diseases or trauma. Although the hydroxyapatite has been widely studied in the literature, there are still some disparities regarding its mechanical performance. This paper presents the analysis of the structural performance of hydroxyapatite scaffolds based on experimental tests and numerical simulations. HA scaffolds with variable porosity were fabricated by the water soluble polymer method, using the Poly Vinyl Alcohol (PVA) as pore former. These scaffolds were then characterized by scanning electronic microscopy (SEM), stereo microscope and X ray diffraction (XRD). Different porous structures models were considered and analyzed by the finite element method (FEM). Compressive tests were carried out and used to validate the proposed numerical models. Also a theoretical analysis based on the Gibson and Ashby [1] model was performed. Finally the experimental, numerical and theoretical results were compared and the results show that the proposed numerical and theoretical models can be used to predict, with adequate accuracy, the mechanical behavior of HA scaffolds for different porosity values.

Monodisperse Mesoporous Silica Spheres Inside a Bioactive Macroporous Glass-Ceramic Scaffold

2010 ◽  
Vol 12 (7) ◽  
pp. B256-B259 ◽  
Author(s):  
Renato Mortera ◽  
Francesco Baino ◽  
Gianluca Croce ◽  
Sonia Fiorilli ◽  
Chiara Vitale-Brovarone ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Glass Ceramic ◽  
Silica Spheres ◽  
Ceramic Scaffold ◽  
Macroporous Glass ◽  
Mesoporous Silica Spheres

Macroporous glass-ceramic materials with bioactive properties

2004 ◽  
Vol 15 (3) ◽  
pp. 209-217 ◽  
Author(s):  
C. Vitale-Brovarone ◽  
S. Di Nunzio ◽  
O. Bretcanu ◽  
E. Verné
Keyword(s):  
Glass Ceramic ◽  
Ceramic Materials ◽  
Glass Ceramic Materials ◽  
Bioactive Properties ◽  
Macroporous Glass

A Resorcinol-Formaldehyde Resin as an Embedding Material for Electron Microscopy of Membranes

1969 ◽  
Vol 27 ◽  
pp. 328-329 ◽  
Author(s):  
J. G. Robertson ◽  
D. F. Parsons
Keyword(s):  
Electron Microscopy ◽  
Osmium Tetroxide ◽  
Neutral Lipids ◽  
Lipid Extraction ◽  
Water Soluble ◽  
Formaldehyde Resin ◽  
Electron Microscope Autoradiography ◽  
Resorcinol Formaldehyde ◽  
Major Disadvantage ◽  
Cell Organization

The extraction of lipids from tissues during fixation and embedding for electron microscopy is widely recognized as a source of possible artifact, especially at the membrane level of cell organization. Lipid extraction is also a major disadvantage in electron microscope autoradiography of radioactive lipids, as in studies of the uptake of radioactive fatty acids by intestinal slices. Retention of lipids by fixation with osmium tetroxide is generally limited to glycolipids, phospholipids and highly unsaturated neutral lipids. Saturated neutral lipids and sterols tend to be easily extracted by organic dehydrating reagents prior to embedding. Retention of the more saturated lipids in embedded tissue might be achieved by developing new cross-linking reagents, by the use of highly water soluble embedding materials or by working at very low temperatures.

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