Structural and dynamical characterization of the Miz-1 zinc fingers 5–8 by solution-state NMR

Two new π-conjugated polymers (Poly[(N-10’-(octan-3-yl)-phenothiazin-3,7-ylene)-alt- (4’,7’-bis(thiophen-2-yl)benzo[c][1,2,5]thiadiazole)] (PoPTZ-BT-BTD), Poly[(N-10`-(octan-3-yl) -phenothiazin-3,7-ylene)-alt-(4’,7’-bis(thiophen-2-yl)-5,6-bis(octyloxy)benzo[c][1,2,5]thiadiazole)] (PoPTZ-BT-BoBTD) ) were synthesized through the Suzuki coupling reaction for organic photovoltaics (OPVs), and their optical and electrochemical properties were analyzed. Their wavelength of maximun absorption was 526 nm and 506 nm in solution state, repectively, and 560 nm and 522 nm in film state, respectively. Their band-gap energy was 2.01 eV and 2.09 eV in solution state, and 1.82 eV and 1.91 eV in film state, respectively. The results of analysis of the chrateristics of photovoltaics, 0.79 % and 0.99 % of the maximum power conversion efficiencies (PCE), repectively.

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Phosphate Substituted Phosphazenes as Dispersants in Colloidal Ceramic Processing

MRS Proceedings ◽

10.1557/proc-249-267 ◽

1991 ◽

Vol 249 ◽

Cited By ~ 1

Author(s):

Sarah D. Burton ◽

William D. Samuels ◽

Gregory J. Exarhos

Keyword(s):

Raman Spectroscopy ◽

31P Nmr ◽

Synthesis And Characterization ◽

Ceramic Processing ◽

Reaction Conditions ◽

Solution State

ABSTRACTA new phosphate substituted phosphazene trimer [N3P3Cl5(OP(O)Ph2)] has been synthesized and characterized by 31p NMR and Raman spectroscopy. The course of each solution-state substitution was followed with 31P NMR, and this technique was used to determine the best reaction conditions for the experiment. Information such as phosphorus to phosphorus connectivity and purity were analyzed. This paper will discuss the synthesis and characterization of phosphazene moieties which are substituted by phosphorus(V) centered substituents.

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Pretreatment of anaerobic digester samples by hydrochloric acid for solution-state 1H and 13C NMR spectroscopic characterization of organic matter

Chemosphere ◽

10.1016/j.chemosphere.2018.02.015 ◽

2018 ◽

Vol 199 ◽

pp. 201-209 ◽

Cited By ~ 9

Author(s):

Sepehr Shakeri Yekta ◽

Mattias Hedenström ◽

Jan Eric Stehr ◽

Mårten Dario ◽

Norbert Hertkorn ◽

...

Keyword(s):

Organic Matter ◽

Hydrochloric Acid ◽

13C Nmr ◽

Spectroscopic Characterization ◽

Anaerobic Digester ◽

1H And 13C Nmr ◽

Solution State

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Solution State NMR Techniques Applied to Solid State Samples: Characterization of Benzoic Acid Confined in MCM-41

The Journal of Physical Chemistry C ◽

10.1021/jp910622m ◽

2010 ◽

Vol 114 (19) ◽

pp. 8884-8891 ◽

Cited By ~ 40

Author(s):

Thierry Azais ◽

Geoffrey Hartmeyer ◽

Sandrine Quignard ◽

Guillaume Laurent ◽

Florence Babonneau

Keyword(s):

Solid State ◽

Benzoic Acid ◽

Solution State ◽

Nmr Techniques ◽

Mcm 41

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Characterization of a Family of RanBP2-Type Zinc Fingers that Can Recognize Single-Stranded RNA

Journal of Molecular Biology ◽

10.1016/j.jmb.2010.12.041 ◽

2011 ◽

Vol 407 (2) ◽

pp. 273-283 ◽

Cited By ~ 63

Author(s):

Cuong D. Nguyen ◽

Robyn E. Mansfield ◽

Wilfred Leung ◽

Paula M. Vaz ◽

Fionna E. Loughlin ◽

...

Keyword(s):

Zinc Fingers

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Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN

Science ◽

10.1126/science.aat0572 ◽

2018 ◽

Vol 362 (6414) ◽

pp. eaat0572 ◽

Cited By ~ 87

Author(s):

Quinlan L. Sievers ◽

Georg Petzold ◽

Richard D. Bunker ◽

Aline Renneville ◽

Mikołaj Słabicki ◽

...

Keyword(s):

Transcription Factors ◽

Small Molecules ◽

Zinc Finger ◽

Ubiquitin Ligase ◽

Biochemical Analysis ◽

Zinc Fingers ◽

Functional Characterization ◽

C2h2 Zinc Finger

The small molecules thalidomide, lenalidomide, and pomalidomide induce the ubiquitination and proteasomal degradation of the transcription factors Ikaros (IKZF1) and Aiolos (IKZF3) by recruiting a Cys2-His2 (C2H2) zinc finger domain to Cereblon (CRBN), the substrate receptor of the CRL4CRBN E3 ubiquitin ligase. We screened the human C2H2 zinc finger proteome for degradation in the presence of thalidomide analogs, identifying 11 zinc finger degrons. Structural and functional characterization of the C2H2 zinc finger degrons demonstrates how diverse zinc finger domains bind the permissive drug-CRBN interface. Computational zinc finger docking and biochemical analysis predict that more than 150 zinc fingers bind the drug-CRBN complex in vitro, and we show that selective zinc finger degradation can be achieved through compound modifications. Our results provide a rationale for therapeutically targeting transcription factors that were previously considered undruggable.

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Synthesis and characterization of metallophosphazene derivatives: solution state and surface reactions

Chemistry of Materials ◽

10.1021/cm00033a021 ◽

1993 ◽

Vol 5 (9) ◽

pp. 1307-1314 ◽

Cited By ~ 7

Author(s):

Harry R. Allcock ◽

Eric N. Silverberg ◽

Constance J. Nelson ◽

William D. Coggio

Keyword(s):

Surface Reactions ◽

Synthesis And Characterization ◽

Solution State

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The GLI-Kruppel family of human genes.

Molecular and Cellular Biology ◽

10.1128/mcb.8.8.3104 ◽

1988 ◽

Vol 8 (8) ◽

pp. 3104-3113 ◽

Cited By ~ 175

Author(s):

J M Ruppert ◽

K W Kinzler ◽

A J Wong ◽

S H Bigner ◽

F T Kao ◽

...

Keyword(s):

Amino Acid ◽

Amino Acid Sequence ◽

Zinc Fingers ◽

Molecular Probe ◽

Sequence Determination ◽

Chromosome Localization ◽

Finger Protein ◽

Expression Studies ◽

Human Genes

Previous characterization of GLI, a gene found to be amplified and expressed in a subset of human brain tumors, revealed the presence of five tandem zinc fingers related to those of Krüppel (Kr), a Drosophila segmentation gene of the gap class. We have used the GLI cDNA as a molecular probe to isolate related sequences from the human genome. Partial characterization of six related loci, including sequence determination, expression studies, and chromosome localization, revealed that each locus could encode a separate finger protein. The predicted proteins all had similar H-C links, i.e., a conserved stretch of 9 amino acids connecting the C-terminal histidine of one finger to the N-terminal cysteine of the next. On the basis of amino acid sequence and intron-exon organization, the genes could be placed into one of two subgroups: the GLI subgroup (with the consensus finger amino acid sequence [Y/F]XCX3GCX3[F/Y]X5LX2HX3-4H[T/S]GEKP) or the Kr subgroup (with the consensus finger amino acid sequence [Y/F]XCX2CX3FX5LX2HXRXHTGEKP). Unlike GLI or Kr, most of the newly isolated genes were expressed in many adult tissues. The predicted proteins probably control the expression of other genes and, by analogy with Kr and GLI, may be important in human development, tissue-specific differentiation, or neoplasia.

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