Fluorescence Imaging of Stem Cells, Cancer Cells and Semi-Thin Sections of Tissues using Silica-Coated CdSe Quantum Dots

AbstractLuminescent quantum dots (QDs) are emerging as a new class of biological labels with unique properties and applications that are not available from traditional organic dyes and fluorescent proteins. Here we report new developments in using semiconductor quantum dots for quantitative imaging and spectroscopy of single cancer cells. We show that both live and fixed cells can be labeled with multicolor QDs, and that single cells can be analyzed by fluorescence imaging and wavelength-resolved spectroscopy. These results raise new possibilities in cancer imaging, molecular profiling, and disease staging.

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Quantum-Dots-Doped ORMOSIL Nanoparticles as Optical Probes for Total Internal Reflection Fluorescence Imaging of Cancer Cells

IEEE Journal of Selected Topics in Quantum Electronics ◽

10.1109/jstqe.2009.2017730 ◽

2009 ◽

Vol 15 (5) ◽

pp. 1374-1379 ◽

Cited By ~ 6

Author(s):

Jun Qian ◽

Qiulan Chen ◽

Fuhong Cai ◽

S.K. Kong ◽

H.P. Ho ◽

...

Keyword(s):

Quantum Dots ◽

Cancer Cells ◽

Fluorescence Imaging ◽

Total Internal Reflection ◽

Internal Reflection ◽

Total Internal Reflection Fluorescence ◽

Optical Probes ◽

Ormosil Nanoparticles

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In Vivo Fluorescence Imaging and the Diagnosis of Stem Cells Using Quantum Dots for Regenerative Medicine

Analytical Chemistry ◽

10.1021/acs.analchem.6b04763 ◽

2017 ◽

Vol 89 (5) ◽

pp. 2671-2681 ◽

Cited By ~ 44

Author(s):

Hiroshi Yukawa ◽

Yoshinobu Baba

Keyword(s):

Stem Cells ◽

Quantum Dots ◽

Regenerative Medicine ◽

Fluorescence Imaging ◽

In Vivo Fluorescence ◽

In Vivo Fluorescence Imaging

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Multifunctional gadolinium-labeled silica-coated core/shell quantum dots for magnetic resonance and fluorescence imaging of cancer cells

RSC Advances ◽

10.1039/c4ra02424a ◽

2014 ◽

Vol 4 (40) ◽

pp. 20641-20648 ◽

Cited By ~ 22

Author(s):

Babao Lin ◽

Xiuzhong Yao ◽

Yihua Zhu ◽

Jianhua Shen ◽

Xiaoling Yang ◽

...

Keyword(s):

Quantum Dots ◽

Magnetic Resonance ◽

Cancer Cells ◽

Fluorescence Imaging ◽

Core Shell ◽

Shell Nanoparticles ◽

High Relaxivity ◽

Core Shell Nanoparticles

Multifunctional gadolinium-labeled silica-coated core/shell nanoparticles with high relaxivity and photoluminescence were synthesized for dual-modal contrast.

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Folic acid-conjugated core/shell ZnS:Mn/ZnS quantum dots as targeted probes for two photon fluorescence imaging of cancer cells

Acta Biomaterialia ◽

10.1016/j.actbio.2010.10.012 ◽

2011 ◽

Vol 7 (3) ◽

pp. 1327-1338 ◽

Cited By ~ 144

Author(s):

Malgorzata Geszke ◽

Marek Murias ◽

Lavinia Balan ◽

Ghouti Medjahdi ◽

Jaroslaw Korczynski ◽

...

Keyword(s):

Quantum Dots ◽

Folic Acid ◽

Cancer Cells ◽

Fluorescence Imaging ◽

Core Shell ◽

Two Photon ◽

Two Photon Fluorescence ◽

Photon Fluorescence

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Phospholipid-stabilized CuxAg1−xInSe2 nanocrystals as luminophores: fabrication, optical properties, and biological application

Journal of Materials Chemistry C ◽

10.1039/d0tc00014k ◽

2020 ◽

Vol 8 (17) ◽

pp. 5821-5831 ◽

Cited By ~ 3

Author(s):

Jinhang Hu ◽

Jiangluqi Song ◽

Zhishu Tang ◽

Huan Li ◽

Lin Chen ◽

...

Keyword(s):

Stem Cells ◽

Optical Properties ◽

Cancer Stem Cells ◽

Cancer Cells ◽

Fluorescence Imaging ◽

Biological Application

A novel phospholipid-decorated CuxAg1−xInSe2 nanoprobe was fabricated for fast fluorescence imaging of cancer cells and cancer stem cells. A mechanism to understand the PL origin of CuxAg1−xInSe2 nanocrystals was proposed.

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