MA-[d-Leu-4]-OB3, a Small Molecule Synthetic Peptide Leptin Mimetic, Mirrors the Cognitive Enhancing Action of Leptin in a Mouse Model of Type 1 Diabetes Mellitus and Alzheimer’s Disease-Like Cognitive Impairment

Diabetes mellitus type 1 is associated with impaired cognitive function. Based on the results of systematic reviews and meta-analyzes, the most likely modifiable risk factor is the degree of metabolic control, in particular the variability of glycemia. Aims: to determine the influence of the variability of glycemia on cognitive functions in patients with type 1 diabetes mellitus. Material and methods. Design-observational, one-stage, cross-sectional research. We examined 30 patients with type 1 diabetes mellitus who were divided into 2 groups: 1 group (main) with cognitive impairment, and 2 (control) with normal cognitive functions. All patients were screened for cognitive functions using the Montreal scale (MoCa test). For the diagnosis of fluctuations in glucose level, continuous monitoring of glycemia was carried out using the iPro-2 device (Medtronic, USA): mean glycemic mean (MEAN), standard deviation (SD), mean amplitude of glycemic fluctuation (MAGE), long-term glycemic index (CONGA) Glycemia lability index (LI), hypoglycemia risk index (LBGI), hyperglycemia risk index (HBGI), mean hourly rate of glycemic change (MAG). Results. The study revealed that in patients with type 1 diabetes mellitus, cognitive impairment was dominated by a violation of constructive praxis, memory and attention. Recorded a significant difference in MEAN, SD, CONGA, Gindex, LBGI, HBGI, MAGE, Mvalue and MAG. Correlation analysis revealed the relationship of cognitive impairments with the level of HbA1c, as well as the variability parameters MEAN, SD, CONGA, Gindex, LBGI, HBGI, MAGE, Mvalue, MAG. Conclusions. The relationship between the variability of glycemia and cognitive impairment was registered in patients with type 1 diabetes mellitus

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Characteristics of cognitive function in patients with diabetes mellitus type 1 younger depending transferred hypoglycemic conditions

East European Journal of Neurology ◽

10.33444/2411-5797.2017.1(13).17-21 ◽

2017 ◽

pp. 17-21

Author(s):

N. Zherdоva ◽

B. Mankovsky

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Cognitive Impairment ◽

Cognitive Function ◽

Type 1 Diabetes Mellitus ◽

Depression Scale ◽

Diabetes Mellitus Type 1 ◽

Diabetes Mellitus Type ◽

Patients With Diabetes

Many studies focus on the effect of compensation of diabetes, glucose-lowering therapy of choice, the influence of cardio - vascular diseases in the state of cognition. At the same time, not enough attention is paid to cognitive impairment in patients with type 1 diabetes mellitus, especially young people. The aim of our study was to investigate the prognostic factors of dementia in patients with type 1 diabetes mellitus are younger. 33 patients were examined with type 1 diabetes and 10 people in the control group. Of the 33 patients with diabetes, 21 people had hypoglycemia in the last 3 months and 12 without hypoglycemic states. To identify depression used two questionnaires: Centre for Epidemiologic Studies Depression Scale (CES-D) and the Hospital Anxiety and Depression Scale (HAD). Evaluation of cognitive impairment was conducted using the following methods: The test "5 words", sample Schulte, the scale of assessment of mental status ( MMSE), test battery on the frontal dysfunction (BLD), evaluation of test o’clock. To reveal the 10-year risk of dementia patients used the scale which was developed by a team of researchers at Utrecht University Medical Rudolf Magnus. In patients with type 1 diabetes with hypoglycemia marked deterioration in cognitive function, according to the neuropsychological tests, namely the BLD and MMSE compared with patient without hypoglycemia. The risk of developing dementia over 10 years in patients with diabetes mellitus type 1 young up 2.2 times compared with patients without hypoglycemia. Hypoglycemic state is the main risk factor that leads to the development of cognitive impairment, and this is a factor which can be influenced by insulin properly selected.

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Decreased Amplitude of the Photopic Negative Response (PhNR) in the Ins2Akita Mouse Model of Type 1 Diabetes Mellitus

The FASEB Journal ◽

10.1096/fasebj.2019.33.1_supplement.554.7 ◽

2019 ◽

Vol 33 (S1) ◽

Author(s):

Lourdes Alarcon Fortepiani ◽

Dung Le ◽

Nikolay P Akimov ◽

Jeong‐Hyeon Sohn ◽

René C Rentería

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Mouse Model ◽

Type 1 Diabetes Mellitus ◽

Negative Response ◽

Photopic Negative Response

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Morphometric characteristics of the brain in patients with type 1 diabetes mellitus on diff erent modes of basic bolus insulin therapy

Clinical Medicine (Russian Journal) ◽

10.30629/0023-2149-2020-98-5-363-367 ◽

2020 ◽

Vol 98 (5) ◽

pp. 363-367

Author(s):

Yu.G Yu.G Samoilova ◽

M. V. Matveeva ◽

O. S. Tonkikh ◽

O. P. Leiman ◽

N. Yu. Fimushkina ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Cognitive Impairment ◽

Insulin Therapy ◽

Type 1 Diabetes Mellitus ◽

Cognitive Functions ◽

Glycemic Variability ◽

Morphometric Characteristics ◽

The Brain

Objective — to study the morphometric characteristics of the brain in patients with type 1 diabetes mellitus (DM) receiving insulin therapy in diff erent modes, taking into account the variability of glycemia. Material and methods. 120 patients with type 1 diabetes, living in Tomsk and the Tomsk Region, were examined. All patients were divided into 2 groups: group 1 — patients receiving insulin in the base-bolus regimen of multiple insulin injections (MII), group 2 — using pump insulin therapy by continuous subcutaneous infusion of insulin using a wearable dispenser (CSII). Patients took this therapy for at least 6 months before inclusion in the study. All patients underwent a general clinical examination, testing of cognitive functions using the Montreal scale (MoCA test), continuous monitoring of blood glycemia (CMG) using iPro™ 2 Professional Continuous Glucose Monitoring (Medtronic, USA), FreeStyle Libre (Abbot, USA) in for 14 days, standard magnetic resonance imaging (MRI) on a 1.5 Tesla apparatus in axial, sagittal and coronal projections using T2, TE, T1, and using programs that suppress the signal of free water. We processed the results of MRI using Free Surfer (USA) and recon-all segmentation algorithm. Statistical analysis was performed using the R-system software package. Results. It was found that in both groups with type 1 diabetes there was a decrease in cognitive functions. It has been shown that CSII is associated with the best completion of the MoCA test. In addition, it has been reported that more frequent episodes of diabetic ketoacidosis and increased glycated hemoglobin (HbA1c) are the main causes of cognitive impairment in this group of patients. Changes in the morphometric parameters of the brain are interconnected with glycemic variability. Conclusion. In patients with type 1 diabetes, cognitive impairment associated with acute and chronic hyperglycemia was verifi ed. Morphometric features of brain changes are more dependent on glycemic variability. CSII helps improve cognitive function.

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Autoimmunity in a mouse model of type 1 diabetes mellitus is triggered by an endocrine abnormality

Immunology Letters ◽

10.1016/s0165-2478(97)88096-0 ◽

1997 ◽

Vol 56 (1-3) ◽

pp. 312

Author(s):

J Rosmalen

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Mouse Model ◽

Type 1 Diabetes Mellitus ◽

Endocrine Abnormality

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