Roles of miRNA-24 in regulating endothelial nitric oxide synthase expression and vascular endothelial cell proliferation

2015 ◽  
Vol 405 (1-2) ◽  
pp. 281-289 ◽  
Author(s):  
Wenyu Zhang ◽  
Limei Yan ◽  
Yumei Li ◽  
Wei Chen ◽  
Nan Hu ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Cell Proliferation ◽  
Endothelial Cell ◽  
Nitric Oxide Synthase ◽  
Endothelial Nitric Oxide Synthase ◽  
Vascular Endothelial Cell ◽  
Endothelial Cell Proliferation ◽  
Vascular Endothelial ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

The smoking-associated oxidant hypothiocyanous acid induces endothelial nitric oxide synthase dysfunction

2013 ◽  
Vol 457 (1) ◽  
pp. 89-97 ◽  
Author(s):  
Jihan Talib ◽  
Jair Kwan ◽  
Aldwin Suryo Rahmanto ◽  
Paul K. Witting ◽  
Michael J. Davies
Keyword(s):  
Nitric Oxide ◽  
Enzyme Activity ◽  
Endothelial Cell ◽  
Nitric Oxide Synthase ◽  
Endothelial Nitric Oxide Synthase ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide ◽  
Monomer Form

The smoking-associated oxidant hypothiocyanous acid converts active dimeric endothelial cell nitric oxide synthase into its monomer form, decreases enzyme activity and releases Zn2+. This is ascribed to targeting of the critical Zn2+–thiol cluster by this thiol-specific oxidant.

Arsenite induces endothelial cytotoxicity by down-regulation of vascular endothelial nitric oxide synthase

2005 ◽  
Vol 208 (3) ◽  
pp. 277-284 ◽  
Author(s):  
Tsui-Chun Tsou ◽  
Feng-Yuan Tsai ◽  
Yao-Wen Hsieh ◽  
Lih-Ann Li ◽  
Szu Ching Yeh ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Endothelial Nitric Oxide Synthase ◽  
Vascular Endothelial ◽  
Down Regulation ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

scholarly journals Role of Endothelial Nitric Oxide Synthase in Endothelial Cell Migration

1999 ◽  
Vol 19 (5) ◽  
pp. 1156-1161 ◽  
Author(s):  
Toyoaki Murohara ◽  
Bernhard Witzenbichler ◽  
Ioakim Spyridopoulos ◽  
Takayuki Asahara ◽  
Bo Ding ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Cell Migration ◽  
Endothelial Cell ◽  
Nitric Oxide Synthase ◽  
Endothelial Nitric Oxide Synthase ◽  
Endothelial Cell Migration ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

scholarly journals Endothelial Dysfunction in Breast Cancer In-Vivo Model

Proceedings ◽  
2018 ◽  
Vol 2 (25) ◽  
pp. 1536
Author(s):  
Buğra Elkar ◽  
Mustafa Barış ◽  
Meryem Çalışır ◽  
Yasemin Çakır ◽  
Safiye Aktaş ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Endothelial Dysfunction ◽  
Nitric Oxide Synthase ◽  
Endothelial Nitric Oxide Synthase ◽  
Growth Factor Receptor ◽  
Vascular Endothelial ◽  
Vascular Endothelial Cadherin ◽  
Oxide Synthase ◽  
Endothelial Growth Factor ◽  
Endothelial Nitric Oxide

Although the endothelial dysfunction is related with tumor development, there is no consensus on the suppressive or supportive effect on tumor growth. The goal of the present study was to evaluate endothelial dysfunction related factors in animal breast cancer model that was developed by administrating endothelial nitric oxide synthase blocking agent, Nitro-L-arginine methyl ester hydrochloride (L-NAME). Endothelial dysfunction related main factors such as nitric oxide synthase, interleukin-6, vascular endothelial growth factor receptor-2 and vascular endothelial cadherin were investigated by immunohistochemically in tumor and carotid artery tissues. In tumor tissues apoptosis was determined by TUNEL assay. The level of endothelin-1 in blood was measured by ELISA. İntima-media thickness of carotid artery was evaluated with Doppler-USG measurements. As a result, in this study it was shown that vascular endothelial growth factor receptor-2, endothelin-1, endothelial nitric oxide synthase, interleukin-6, vascular endothelial cadherin and E-selectin molecules play a role in reducing breast tumor growth based on endothelial dysfunction.

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