Research advances in the role and pharmaceuticals of ATP-binding cassette transporters in autoimmune diseases

Jun Yu ◽  
Hao Chen ◽  
Jiangmei Xu ◽  
Peng Zhou
2003 ◽  
Vol 278 (18) ◽  
pp. 15565-15570 ◽  
Liqing Yu ◽  
Jennifer York ◽  
Klaus von Bergmann ◽  
Dieter Lutjohann ◽  
Jonathan C. Cohen ◽  

2013 ◽  
Vol 136 (2) ◽  
pp. 382-391 ◽  
Anita C. A. Dankers ◽  
Maarke J. E. Roelofs ◽  
Aldert H. Piersma ◽  
Fred C. G. J. Sweep ◽  
Frans G. M. Russel ◽  

2017 ◽  
Vol 9 (4) ◽  
Antonella Maria Salvia ◽  
Flavia Cuviello ◽  
Sabrina Coluzzi ◽  
Roberta Nuccorini ◽  
Immacolata Attolico ◽  

Hematopoietic cells express ATP binding cassette (ABC) transporters in relation to different degrees of differentiation. One of the known multidrug resistance mechanisms in acute myeloid leukemia (AML) is the overexpression of efflux pumps belonging to the superfamily of ABC transporters such as ABCB1, ABCG2 and ABCC1. Although several studies were carried out to correlate ABC transporters expression with drug resistance, little is known about their role as markers of diagnosis and progression of the disease. For this purpose we investigated the expression, by real-time PCR, of some ABC genes in bone marrow samples of AML patients at diagnosis and after induction therapy. At diagnosis, ABCG2 was always down-regulated, while an up regulated trend for ABCC1 was observed. After therapy the examined genes showed a different expression trend and approached the values of healthy subjects suggesting that this event could be considered as a marker of AML regression. The expression levels of some ABC transporters such as ABCC6, seems to be related to gender, age and to the presence of FLT3/ITD gene mutation.

Sign in / Sign up

Export Citation Format

Share Document