Computational design of new protein kinase D 1 (PKD1) inhibitors: homology-based active site prediction, energy-optimized pharmacophore, docking and database screening

Nalini; Navriti Chadha; Malkeet Singh Bahia; Maninder Kaur; Renu Bahadur; Om Silakari

doi:10.1007/s11030-017-9785-0

Computational design of new protein kinase D 1 (PKD1) inhibitors: homology-based active site prediction, energy-optimized pharmacophore, docking and database screening

Molecular Diversity ◽

10.1007/s11030-017-9785-0 ◽

2017 ◽

Vol 22 (1) ◽

pp. 47-56

Author(s):

Nalini ◽

Navriti Chadha ◽

Malkeet Singh Bahia ◽

Maninder Kaur ◽

Renu Bahadur ◽

...

Keyword(s):

Protein Kinase ◽

Active Site ◽

Computational Design ◽

Protein Kinase D ◽

Site Prediction ◽

Database Screening ◽

New Protein

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Computational design of new protein kinase 2 inhibitors for the treatment of inflammatory diseases using QSAR, pharmacophore-structure-based virtual screening, and molecular dynamics

Journal of Molecular Modeling ◽

10.1007/s00894-018-3756-y ◽

2018 ◽

Vol 24 (9) ◽

Cited By ~ 8

Author(s):

Josiane V. Cruz ◽

Rodolfo B. Serafim ◽

Gabriel M. da Silva ◽

Silvana Giuliatti ◽

Joaquín M. C. Rosa ◽

...

Keyword(s):

Molecular Dynamics ◽

Protein Kinase ◽

Virtual Screening ◽

Inflammatory Diseases ◽

Computational Design ◽

New Protein

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Active Site Prediction and Targeting Bipolar Disorder through Molecular Docking Techniques on Protein Kinase Epsilon

International Journal of Scientific Research ◽

10.15373/22778179/june2013/11 ◽

2012 ◽

Vol 2 (6) ◽

pp. 33-35

Author(s):

S. Shanthipriya S. Shanthipriya ◽

◽

Dr. Victor A. Doss

Keyword(s):

Bipolar Disorder ◽

Molecular Docking ◽

Protein Kinase ◽

Active Site ◽

Site Prediction

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Activation of protein kinase D (PKD) by signaling through Rho and the alpha subunit of the heterotrimeric G protein G13

Gastroenterology ◽

10.1016/s0016-5085(01)82478-1 ◽

2001 ◽

Vol 120 (5) ◽

pp. A499-A499

Author(s):

J YUAN ◽

L SLICE ◽

E ROZENGURT

Keyword(s):

Protein Kinase ◽

G Protein ◽

Alpha Subunit ◽

Protein Kinase D ◽

Heterotrimeric G Protein

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Glyburide-stimulated glucose transport in cultured muscle cells via protein kinase C-mediated pathway requiring new protein synthesis

Diabetes ◽

10.2337/diabetes.40.11.1531 ◽

1991 ◽

Vol 40 (11) ◽

pp. 1531-1538 ◽

Cited By ~ 3

Author(s):

M. B. Davidson ◽

I. G. Molnar ◽

A. Furman ◽

D. Yamaguchi

Keyword(s):

Protein Synthesis ◽

Protein Kinase C ◽

Protein Kinase ◽

Glucose Transport ◽

Muscle Cells ◽

Kinase C ◽

New Protein

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Faculty Opinions recommendation of Protein kinase D regulates vesicular transport by phosphorylating and activating phosphatidylinositol-4 kinase IIIbeta at the Golgi complex.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1027702.334773 ◽

2005 ◽

Author(s):

Adam Linstedt

Keyword(s):

Protein Kinase ◽

Golgi Complex ◽

Vesicular Transport ◽

Protein Kinase D ◽

Phosphatidylinositol 4

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The Role of Protein Kinase D (PKD) Signaling in Breast Cancer Cell Migration and Invasion

10.21236/ada548836 ◽

2010 ◽

Author(s):

Claudine Christoforides

Keyword(s):

Breast Cancer ◽

Cell Migration ◽

Protein Kinase ◽

Cancer Cell ◽

Breast Cancer Cell ◽

Migration And Invasion ◽

Protein Kinase D ◽

Cancer Cell Migration ◽

Cell Migration And Invasion

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Protein kinase D enzymes: novel kinase targets in pancreatic cancer

Expert Review of Gastroenterology & Hepatology ◽

10.1586/17474124.2015.1069706 ◽

2015 ◽

Vol 9 (9) ◽

pp. 1143-1146 ◽

Cited By ~ 2

Author(s):

Geou-Yarh Liou ◽

Peter Storz

Keyword(s):

Pancreatic Cancer ◽

Protein Kinase ◽

Protein Kinase D

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Evaluating the current status of protein kinase C (PKC)-protein kinase D (PKD) signalling axis as a novel therapeutic target in ovarian cancer

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer ◽

10.1016/j.bbcan.2020.188496 ◽

2021 ◽

Vol 1875 (1) ◽

pp. 188496

Author(s):

Komal Tyagi ◽

Adhiraj Roy

Keyword(s):

Ovarian Cancer ◽

Protein Kinase C ◽

Protein Kinase ◽

Therapeutic Target ◽

Current Status ◽

Protein Kinase D ◽

Kinase C ◽

Novel Therapeutic

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Angiotensin II-activated protein kinase D mediates acute aldosterone secretion

Molecular and Cellular Endocrinology ◽

10.1016/j.mce.2009.11.017 ◽

2010 ◽

Vol 317 (1-2) ◽

pp. 99-105 ◽

Cited By ~ 17

Author(s):

Brian A. Shapiro ◽

Lawrence Olala ◽

Senthil Nathan Arun ◽

Peter M. Parker ◽

Mariya V. George ◽

...

Keyword(s):

Angiotensin Ii ◽

Protein Kinase ◽

Protein Kinase D ◽

Aldosterone Secretion

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Protein Kinase D Is Implicated in the Reversible Commitment to Differentiation in Primary Cultures of Mouse Keratinocytes

Journal of Biological Chemistry ◽

10.1074/jbc.m110.105619 ◽

2010 ◽

Vol 285 (30) ◽

pp. 23387-23397 ◽

Cited By ~ 23

Author(s):

Azadeh Jadali ◽

Soosan Ghazizadeh

Keyword(s):

Protein Kinase ◽

Primary Cultures ◽

Protein Kinase D ◽

Mouse Keratinocytes

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