Exploring the molecular role of endostatin in diabetic neuropathy

2021 ◽  
Vol 48 (2) ◽  
pp. 1819-1836
Author(s):  
Tuhin Mukherjee ◽  
Tapan Behl ◽  
Aayush Sehgal ◽  
Saurabh Bhatia ◽  
Harmanpreet Singh ◽  
...  
Keyword(s):  
Diabetic Neuropathy

The Role of Diabetes Mellitus in Diseases of the Gallbladder and Biliary Tract

2020 ◽  
Vol 16 (9) ◽  
pp. 931-948
Author(s):  
Benjamin Rahmani ◽  
Jason Gandhi ◽  
Gunjan Joshi ◽  
Noel L. Smith ◽  
Inefta Reid ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Diabetic Neuropathy ◽  
Gallbladder Cancer ◽  
Biliary Tract ◽  
Treatment Approach ◽  
Database Search ◽  
Heavy Burden ◽  
Prevalence Of Diabetes Mellitus

Background: The increasing prevalence of diabetes mellitus worldwide continues to pose a heavy burden. Though its gastrointestinal impact is appropriately recognized, the lesser known associations may be overlooked. Objective: We aim to review the negative implications of diabetes on the gallbladder and the biliary tract. Methods: A MEDLINE® database search of literature was conducted with emphasis on the previous five years, combining keywords such as "diabetes," "gallbladder," and "biliary". Results: The association of diabetes to the formation of gallstones, gallbladder cancer, and cancer of the biliary tract are discussed along with diagnosis and treatment. Conclusion: Though we uncover the role of diabetic neuropathy in gallbladder and biliary complications, the specific individual diabetic risk factors behind these developments is unclear. Also, in addition to diabetes control and surgical gallbladder management, the treatment approach also requires further focus.

PROTECTIVE ROLE OF FICUS RACEMOSA IN DIABETES INDUCED NEUROPATHY: STRUCTURAL AND FUNCTIONAL EVIDENCES

INDIAN DRUGS ◽  
2017 ◽  
Vol 54 (11) ◽  
pp. 58-60
Author(s):  
N Solanki ◽  
◽  
S. K Bhavsar
Keyword(s):  
Sciatic Nerve ◽  
Diabetic Neuropathy ◽  
Ethanolic Extract ◽  
Protective Role ◽  
Diabetic Rats ◽  
Dependent Manner ◽  
Traditional System ◽  
Ficus Racemosa ◽  
Dose Dependent

Ficus racemosa is used in traditional system of medicine for various health problems and diseases, and is commonly known as Gular fig. The main objective was to study its effects against streptozotocin induced diabetic neuropathy by structural and functional marker. Investigation of diabetic neuropathy was carried out through functional and structural assessment in streptozotocin induced in diabetic rats. Diabetic rats were treated for 28 days in dose dependent manner of Ficus racemosa aqueous extract (250 mg/kg and 500 mg/kg) and ethanolic extract (200 mg/kg and 400 mg/kg). Study showed marked protection observed by Ficus racemosa in hippocampus region of brain and sciatic nerve tissues. Ficus racemosa treatment showed improvement in functional and structural markers, which strongly suggest its protective role in diabetic neuropathy.

The role of ultrasound in the diagnosis and evaluation of diabetic neuropathy in nerve roots of the foot

2018 ◽  
Vol 2 (1) ◽  
pp. 1
Author(s):  
DoaaM.M Abd El-Sameea ◽  
Mohamed Abdel Latief Mahmoud ◽  
AshrafT Yousef ◽  
SaidS Said
Keyword(s):  
Diabetic Neuropathy ◽  
Nerve Roots

The role of surgical decompression for diabetic neuropathy

2004 ◽  
Vol 9 (2) ◽  
pp. 239-254 ◽  
Author(s):  
Kent R Biddinger ◽  
Kari J Amend
Keyword(s):  
Diabetic Neuropathy ◽  
Surgical Decompression

scholarly journals The role of RAGE in the diabetic neuropathy

2015 ◽  
Vol 4 ◽  
pp. 316-318
Author(s):  
Judyta K. Juranek ◽  
Marta Banach
Keyword(s):  
Diabetic Neuropathy

scholarly journals Spinal Serotonin and 5HT6 Receptor Levels During Development of Neuropathy and Influence of Blockade of these Receptors on Thermal Hyperalgesia in Diabetic Mice

Drug Research ◽  
2019 ◽  
Vol 69 (08) ◽  
pp. 428-433 ◽  
Author(s):  
Cagda Celik Sari ◽  
Ozgur Gunduz ◽  
Ahmet Ulugol
Keyword(s):  
Diabetic Neuropathy ◽  
Single Injection ◽  
Thermal Hyperalgesia ◽  
Receptor Expression ◽  
Diabetic Mice ◽  
Hot Plate ◽  
Hot Plate Test ◽  
Plate Test ◽  
Diabetes Development

AbstractLittle is known about the role of 5-HT6 receptors in the pathophysiology of neuropathic pain. The aim of this study is firstly, to investigate the influence of spinal and systemic 5-HT6 receptors on thermal hyperalgesia, one of the most significant symptoms of neuropathy occurring in diabetes; and secondly to determine spinal lumbar serotonin and 5-HT6 receptor levels during development of diabetic neuropathy in mice. Diabetes was produced in Balb/c mice with a single injection of streptozocin (150 mg/kg, i.p.). Using the hot plate test, the 5-HT6 antagonist SB-258585 was given systemically (3, 10, 30 mg/kg) and intrathecally (0.01, 0.1, 1 nmol/mouse) to determine its effect on thermal hyperalgesia. Furthermore, on days 7 and 15 of diabetes, development of thermal hyperalgesia was evaluated in relation to changes in spinal serotonin and 5-HT6 receptor levels by using LC/MS/MS and Western blot analyses, respectively. Two-way analysis of variance and unpaired t-tests were used to evaluate data from hot-plate tests and 5-HT levels/ 5-HT6 receptor expression, respectively. Thermal hyperalgesia was observed in neuropathic mice, starting from day 5 after streptozocin administration. On day 15, systemic, but not intrathecal, SB-258585 attenuated thermal hyperalgesia in neuropathic mice. Spinal serotonin levels did not change during development of hyperalgesia after induction of diabetes, whereas spinal 5-HT6 receptor levels were significantly reduced on days 7 and 15. Our findings show that systemic, but not spinal, blockade of 5-HT6 receptors may exert antihyperalgesic effects in neuropathic mice and suggest that systemic 5-HT6 receptors contribute to the pathophysiology of diabetic neuropathy.

Sign in / Sign up

Export Citation Format

Share Document