Zonisamide: Antihyperalgesic efficacy, the role of serotonergic receptors on efficacy in a rat model for painful diabetic neuropathy

Life Sciences ◽  
2014 ◽  
Vol 95 (1) ◽  
pp. 9-13 ◽  
Author(s):  
Nurcan Bektas ◽  
Rana Arslan ◽  
Yusuf Ozturk
Keyword(s):  
Diabetic Neuropathy ◽  
Rat Model ◽  
Painful Diabetic Neuropathy ◽  
Serotonergic Receptors

Role of T-Type Ca2+ Channels in Painful Diabetic Neuropathy

2019 ◽  
Vol 51 (6) ◽  
pp. 455-461
Author(s):  
P. V. Belan ◽  
Y. M. Usachev ◽  
D. E. Duzhyy ◽  
S. Y. Ivanova ◽  
A. N. Tarasenko ◽  
...  
Keyword(s):  
Diabetic Neuropathy ◽  
Painful Diabetic Neuropathy ◽  
Ca2 Channels

scholarly journals Pathogenesis of Painful Diabetic Neuropathy

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Amir Aslam ◽  
Jaipaul Singh ◽  
Satyan Rajbhandari
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Neuropathic Pain ◽  
Diabetic Neuropathy ◽  
Peripheral Nerves ◽  
Daily Life ◽  
Painful Diabetic Neuropathy ◽  
Common Cause ◽  
The Central Nervous System

The prevalence of diabetes is rising globally and, as a result, its associated complications are also rising. Painful diabetic neuropathy (PDN) is a well-known complication of diabetes and the most common cause of all neuropathic pain. About one-third of all diabetes patients suffer from PDN. It has a huge effect on a person’s daily life, both physically and mentally. Despite huge advances in diabetes and neurology, the exact mechanism of pain causation in PDN is still not clear. The origin of pain could be in the peripheral nerves of the central nervous system. In this review, we discuss various possible mechanisms of the pathogenesis of pain in PDN. We discuss the role of hyperglycaemia in altering the physiology of peripheral nerves. We also describe central mechanisms of pain.

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