π-Hole Tetrel Bonds—Lewis Acid Properties of Metallylenes

The MP2/aug-cc-pVTZ calculations were performed on the dihalometallylenes to indicate their Lewis acid and Lewis base sites. The results of the Cambridge Structural Database search show corresponding and related crystal structures where the tetrel center often possesses the configuration of a trigonal bipyramid or octahedron. The calculations were also carried out on dimers of dichlorogermylene and dibromogermylene and on complexes of these germylenes with one and two 1,4-dioxide molecules. The Ge⋯Cl, Ge⋯Br, and Ge⋯O interactions are analyzed. The Ge⋯O interactions in the above mentioned germylene complexes may be classified as the π-hole tetrel bonds. The MP2 calculations are supported by the results of the Quantum Theory of Atoms in Molecules (QTAIM) and the Natural Bond Orbital (NBO) approaches.

Terrorist Attacks in Western Europe: A Counter-Terrorism Medicine Analysis

Background: The modern concept of terrorism has its roots in the “old continent” of Western Europe, more specifically in France, during the “Reign of Terror” period of the French Revolution. At the time, this form of state terror had a positive connotation: it was a legitimate means of defending the young state. While no single accepted definition of terrorism exists today, it is universally considered an attack on both state and society. The health care impacts of terrorist attacks often extend disproportionally beyond the casualty toll, but the potential for such events to induce mass casualties remains a concern to Disaster Medicine and Counter-Terrorism Medicine (CTM) specialists. Method: Data collection was performed using a retrospective database search through the Global Terrorism Database (GTD). The GTD was searched using the internal database search functions for all events which occurred in Western Europe from January 1, 1970 - December 31, 2019. Years 2020 and 2021 were not yet available at the time of the study. Primary weapon type, country where the incident occurred, and number of deaths and injured were collated. Results were exported into an Excel spreadsheet (Microsoft Corp.; Redmond, Washington USA) for analysis. Results: A total of 15,306 events were recorded in Western Europe out of a total of 201,183 events world-wide between the years 1970 and 2019 inclusive. This resulted in a total of 5,548 deaths and 17,187 injuries. Explosives were used as a primary weapon/attack modality in 8,103 attacks, followed by incendiary attacks in 3,050 events and firearm use in 2,955 events. The use of chemical, biological, radiation, and nuclear (CBRN) weapons was rare and only accounted for 47 events. Conclusion: From 1970 through 2019, 9.11% of all terrorist attacks occurred in Western Europe. Compared to global trends of attack methodologies in the same study period, the use of explosives as a primary attack modality in Western Europe was similar (52.94% in Western Europe versus 48.78% Global). Firearm use was comparatively low (19.31% versus 26.77%) and the use of CBRN as an attack modality was rare (0.30% versus 0.20%). The United Kingdom, Spain, and France accounted for over 65% of all terrorist attacks and over 75% of terrorism-related deaths in Western Europe.

A Scoping Review Examining Interventions Intended to Help LGBTQIA+ Youth Transition Out of Homelessness

Objective: Youth self-identifying as lesbian, gay, bisexual, transgender, questioning/queer, intersex, asexual, and other identities (LGBTQIA+) are overrepresented among the homeless youth population in western countries. Although scholars have documented the situations and events contributing to disproportionately high rates of homelessness among LGBTQIA+ youth compared to cisgender peers, researchers have not as thoroughly examined the efficacy of services available to this group to assist their transition from homelessness to stable residency. The purpose of this scoping review was to examine the peer-reviewed literature to determine how many journal articles have been generated that addressed (a) the assessment of client satisfaction or (b) the effectiveness of intervention designed to help LGBTQIA+ homeless youth transition from homelessness to stable tenancy. Method: A database search of six peer-reviewed, health care publication indexes, with 50 key search terms was performed. The database search spanned publication years with no beginning year, but ended in January 2021. Results: Nineteen articles were identified that described programming, reported intervention outcomes, or outlined policies and recommendations intended to help LGBTQIA+ youth transition out of homelessness. Of the 19 studies, only five (26.31%) reported program evaluation (n=1, 5.26%), the assessment of intervention effectiveness (n=2, 10.52%), or an analysis of client satisfaction (n=2, 10.52%). Findings exemplify the dearth of scholarship and research examining this area of academic inquiry and public health need. Discussion: Without empirical research investigating service provision for the LGBTQIA+ homeless youth population, service providers have little data upon which to inform practice based on an understanding of the services that are needed and desired by this population to transition out of homelessness, the effectiveness and perceived satisfaction of those services, and whether services should be modified to better meet the needs of those for whom it was intended. Scholars and researchers are called upon to generate this needed public health research, which should include service recipient perspectives to target outcomes and interpret findings.

Analysing the Obstacles in Agile Software Development Approach: A Review

The development of reusable and extensible software for business purposes has been the hallmark of the day. More developers are taking advantage of numerous approaches towards reaching their goals. One such approach is the agile approach in the development of extensible applications which has become so popular since its introduction over a decade ago. Using an agile approach that has a defined value in developing applications portray numerous benefits which have been identified by various scholars pointing out their outcomes as motivating factors of its adoption. With all such outline benefits, there exist some potential obstacles to agile developmental approach which has not been fully addressed. Hence, this article is aimed at analysing the obstacles which software developers face during agile development through a database search and also to guide them on ways to overcome such obstacles.

Drug-Induced QT Interval Prolongation

The correct measurement of the QT interval (using the QT correction formulas, preferably Fridericia and Framingham) as well as a correct interpretation of the causes and of the clinical consequences of a QT prolongation is very important in clinical practice. Drug-induced long QT syndrome (DILQTS) is one of the most common causes of LQTS. In the diagnosis and management of the DILQTS, it can be useful to follow the three-step rule presented in this article: detailed pharmacological anamnesis and correct ECG interpretation; database search and clinical interpretation; confirmatory test.

Urtica dioica (Stinging Nettle) – Properties, Uses and Applications

Utricaceae is a family of herbs and shrubs that can be found in a variety of habitats around the world. A lot of research has been carried out till date targeted for close understanding of this medicinal plant. The botanical distribution, Ethnomedicinal applications, Traditional uses as well as Pharmacological properties of the Urtica genus, are discussed in this study. The composition such as flavonoids and array of phenolic compounds which includes alcohols, Diocanol, Diol glucosides, Terpenes diols, and sugars as well are an inclusion in the genus Urtica. A wide range of research reports have been published representing its biological and pharmacological potential against cancer, tumors, bacterial, viral or fungal infections significantly. The information about the Urtica genus has been extracted using electronic database search such as Google Scholar and Pubmed as well as a library search for peer-reviewed journal publications.

Non-SARS, non-MERS human coronavirus infections and risk of Kawasaki disease: a meta-analysis

Aim: To study the association between non-SARS, non-MERS human coronavirus (HCoV) infections and Kawasaki disease (KD). Methods: Meta-analysis of observational studies published until 1 May 2021. Results: Out of 571 papers retrieved through database search, 10 provided data of 17,732 children. Age ranged from 2 months–14.9 years with 66% being male and 71% being complete KD. Compared with controls, there was an increased risk of developing KD in those detected to have HCoV infection (OR: 2.3 [95% CI: 1.06–4.99]; p = 0.03). The GRADE evidence for all outcomes was of ‘low-certainty’. Conclusion: A ‘low certainty’ of evidence suggests an increased risk of KD in children infected with HCoV. We need multi-center, prospective studies to support or refute this finding. PROSPERO protocol registration: CRD42021251582.

Diffusion of Platform Thinking as an Innovation in the Construction Supply Chain

The construction industry has received long standing criticism over its fragmented approach to supply chain management, adversarial relationships, and ongoing defects. Platform thinking has been observed in other industries as a phenomenon that offers reinvention from the traditional perspectives on the supply chain. In this study, a scoping review of platform thinking is presented. A database search of 656 papers across 15 journals, along with 3 sources from a Google search and 12 sources from a manual review of the reference lists were reviewed in relation to platform thinking in construction. While many variants of platforms exist, the scoping review demonstrates a focus on product platforms that has historical precedents. This paper highlights the benefits of platform thinking whilst linking to the lessons of the past. This provides a valuable insight for future implications of platform thinking. This paper contributes to the limited literature on platform thinking in the construction industry by linking historical examples with present and potential future investigation.

SugarDrawer: A Web-Based Database Search Tool with Editing Glycan Structures

In life science fields, database integration is progressing and contributing to collaboration between different research fields, including the glycosciences. The integration of glycan databases has greatly progressed collaboration worldwide with the development of the international glycan structure repository, GlyTouCan. This trend has increased the need for a tool by which researchers in various fields can easily search glycan structures from integrated databases. We have developed a web-based glycan structure search tool, SugarDrawer, which supports the depiction of glycans including ambiguity, such as glycan fragments which contain underdetermined linkages, and a database search for glycans drawn on the canvas. This tool provides an easy editing feature for various glycan structures in just a few steps using template structures and pop-up windows which allow users to select specific information for each structure element. This tool has a unique feature for selecting possible attachment sites, which is defined in the Symbol Nomenclature for Glycans (SNFG). In addition, this tool can input and output glycans in WURCS and GlycoCT formats, which are the most commonly-used text formats for glycan structures.