<p>The article demonstrates the importance of using
a suitable approach to compensate for dead time relate count losses (a certain
measurement artefact) whenever short, but potentially strong transient signals are
to be analysed using inductively coupled plasma mass spectrometry (ICP-MS).
Findings strongly support the theory that inadequate time resolution, and
therefore insufficient compensation for these count losses, is one of the main
reasons for size underestimation observed when analysing inorganic
nanoparticles using ICP-MS, a topic still controversially discussed.</p>
Quantification of Al2O3 nanoparticles in human cell lines applying inductively coupled plasma mass spectrometry (neb-ICP-MS, LA-ICP-MS) and flow cytometry-based methods