scholarly journals Nonlinear dynamics and Poincaré sections to model gait impairments in different stages of Parkinson’s disease

2020 ◽  
Vol 100 (4) ◽  
pp. 3253-3276
Author(s):  
P. A. Pérez-Toro ◽  
J. C. Vásquez-Correa ◽  
T. Arias-Vergara ◽  
E. Nöth ◽  
J. R. Orozco-Arroyave
Keyword(s):  
Nonlinear Dynamics ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Poincaré Sections ◽  
Poincare Sections ◽  
Gait Impairments

scholarly journals Overload From Anxiety: A Non-Motor Cause for Gait Impairments in Parkinson’s Disease

2018 ◽  
Vol 30 (1) ◽  
pp. 77-80 ◽  
Author(s):  
Kaylena A. Ehgoetz Martens ◽  
Carolina R.A. Silveira ◽  
Brittany N. Intzandt ◽  
Quincy J. Almeida
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Gait Impairments

DEVELOPMENT OF THERAPEUTIC BRAIN STIMULATION TECHNIQUES WITH METHODS FROM NONLINEAR DYNAMICS AND STATISTICAL PHYSICS

2006 ◽  
Vol 16 (07) ◽  
pp. 1889-1911 ◽  
Author(s):  
PETER A. TASS ◽  
CHRISTIAN HAUPTMANN ◽  
OLEKSANDR V. POPOVYCH
Keyword(s):  
Nonlinear Dynamics ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Essential Tremor ◽  
Brain Stimulation ◽  
Brain Function ◽  
Statistical Physics ◽  
Delayed Feedback ◽  
Phase Resetting ◽  
Feedback Mechanisms

Synchronization processes may severely impair brain function, for instance, in Parkinson's disease, essential tremor or epilepsies. We present three different effectively desynchronizing stimulation techniques which have been developed with methods from nonlinear dynamics and statistical physics. These techniques exploit either stochastic phase resetting principles or complex delayed feedback mechanisms. We explain how these methods work and how they can be applied to therapeutic brain stimulation.

scholarly journals Neural Control of Walking in People with Parkinsonism

Physiology ◽  
2016 ◽  
Vol 31 (2) ◽  
pp. 95-107 ◽  
Author(s):  
D. S. Peterson ◽  
F. B. Horak
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Basal Ganglia ◽  
Postural Control ◽  
Brain Stem ◽  
Neural Control ◽  
Human Locomotion ◽  
Gait Dysfunction ◽  
Gait Impairments

People with Parkinson's disease exhibit debilitating gait impairments, including gait slowness, increased step variability, and poor postural control. A widespread supraspinal locomotor network including the cortex, cerebellum, basal ganglia, and brain stem contributes to the control of human locomotion, and altered activity of these structures underlies gait dysfunction due to Parkinson's disease.

scholarly journals Is Freezing of Gait in Parkinson's Disease a Result of Multiple Gait Impairments? Implications for Treatment

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Meir Plotnik ◽  
Nir Giladi ◽  
Jeffrey M. Hausdorff
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Freezing Of Gait ◽  
Theoretical Framework ◽  
Gait Control ◽  
Gait Symmetry ◽  
Gait Features ◽  
New Treatment ◽  
Functional Gait ◽  
Gait Impairments

Several gait impairments have been associated with freezing of gait (FOG) in patients with Parkinson's disease (PD). These include deteriorations in rhythm control, gait symmetry, bilateral coordination of gait, dynamic postural control and step scaling. We suggest that these seemingly independent gait features may have mutual interactions which, during certain circumstances, jointly drive the predisposed locomotion system into a FOG episode. This new theoretical framework is illustrated by the evaluation of the potential relationships between the so-called “sequence effect”, that is, impairments in step scaling, and gait asymmetry just prior to FOG. We further discuss what factors influence gait control to maintain functional gait. “Triggers”, for example, such as attention shifts or trajectory transitions, may precede FOG. We propose distinct categories of interventions and describe examples of existing work that support this idea: (a) interventions which aim to maintain a good level of locomotion control especially with respect to aspects related to FOG; (b) those that aim at avoiding FOG “triggers”; and (c) those that merely aim to escape from FOG once it occurs. The proposed theoretical framework sets the stage for testable hypotheses regarding the mechanisms that lead to FOG and may also lead to new treatment ideas.

scholarly journals Mild Gait Impairment and Its Potential Diagnostic Value in Patients with Early-Stage Parkinson’s Disease

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Zhuang Wu ◽  
Xu Jiang ◽  
Min Zhong ◽  
Bo Shen ◽  
Jun Zhu ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Early Stage ◽  
Wearable Sensors ◽  
Diagnostic Value ◽  
Gait Pattern ◽  
Heel Strike ◽  
Phase Time ◽  
Gait Parameters ◽  
Gait Impairments

Background and Purpose. Patients with early-stage Parkinson’s disease (PD) have gait impairments, and gait parameters may act as diagnostic biomarkers. We aimed to (1) comprehensively quantify gait impairments in early-stage PD and (2) evaluate the diagnostic value of gait parameters for early-stage PD. Methods. 32 patients with early-stage PD and 30 healthy control subjects (HC) were enrolled. All participants completed the instrumented stand and walk test, and gait data was collected using wearable sensors. Results. We observed increased variability of stride length (SL) ( P < 0.001 ), stance phase time (StPT) ( P = 0.004 ), and swing phase time (SwPT) ( P = 0.011 ) in PD. There were decreased heel strike (HS) ( P = 0.001 ), range of motion of knee ( P = 0.036 ), and hip joints ( P < 0.001 ) in PD. In symmetry analysis, no difference was found in any of the assessed gait parameters between HC and PD. Only total steps ( AUC = 0.763 , P < 0.001 ), SL ( AUC = 0.701 , P = 0.007 ), SL variability ( AUC = 0.769 , P < 0.001 ), StPT variability ( AUC = 0.712 , P = 0.004 ), and SwPT variability ( AUC = 0.688 , P = 0.011 ) had potential diagnostic value. When these five gait parameters were combined, the predictive power was found to increase, with the highest AUC of 0.802 ( P < 0.001 ). Conclusions. Patients with early-stage PD presented increased variability but still symmetrical gait pattern. Some specific gait parameters can be applied to diagnose early-stage PD which may increase diagnosis accuracy. Our findings are helpful to improve patient’s quality of life.

scholarly journals Perceptions of Compensation Strategies for Gait Impairments in Parkinson’s Disease: A Survey Among 320 Healthcare Professionals

2020 ◽  
Vol 10 (4) ◽  
pp. 1775-1778
Author(s):  
Anouk Tosserams ◽  
Maarten J. Nijkrake ◽  
Ingrid H.W.M. Sturkenboom ◽  
Bastiaan R. Bloem ◽  
Jorik Nonnekes
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Clinical Practice ◽  
Online Survey ◽  
Healthcare Professionals ◽  
Daily Practice ◽  
Clinical Implications ◽  
Knowledge Gap ◽  
Gait Impairments ◽  
Specific Expertise

Compensation strategies are an essential part of managing gait impairments in people with Parkinson’s disease (PD). We conducted an online survey among 320 healthcare professionals with specific expertise in PD management, to evaluate their knowledge of compensation strategies for gait impairments in people with PD, and whether they applied these in daily practice. Only 35% of professionals was aware of all categories of compensation strategies. Importantly, just 23% actually applied all seven available categories of strategies when treating people with PD in clinical practice. We discuss the clinical implications, and provide recommendations to overcome this knowledge gap.

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