Imaging the Cytosolic Drug Delivery Mechanism of HDL-Like Nanoparticles

Abstract: In recent times, several approaches for targeted gene therapy (GT) had been studied. However, the emergence of extracellular vesicles (EVs) as a shuttle carrying genetic information between cells has gained a lot of interest in scientific communities. Owing to their higher capabilities in dealing with short sequences of nucleic acid (mRNA, miRNA), proteins, recombinant proteins, exosomes, the most popular form of EVs are viewed as reliable biological therapeutic conveyers. They have natural access through every biological membrane and can be employed for site-specific and efficient drug delivery without eliciting any immune responses hence, qualifying as an ideal delivery vehicle. Also, there are many research studies conducted in the last few decades on using exosome-mediated gene therapy into developing an effective therapy with the concept of a higher degree of precision in gene isolation, purification and delivery mechanism loading, delivery and targeting protocols. This review discusses several facets that contribute towards developing an efficient therapeutic regime for gene therapy, highlighting limitations and drawbacks associated with current GT and suggested therapeutic regimes.

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Insight into pulmonary drug delivery: Mechanism of drug deposition to device characterization and regulatory requirements

Pulmonary Pharmacology & Therapeutics ◽

10.1016/j.pupt.2018.11.004 ◽

2019 ◽

Vol 54 ◽

pp. 1-21 ◽

Cited By ~ 11

Author(s):

Nagarjun Rangaraj ◽

Sravanthi Reddy Pailla ◽

Sunitha Sampathi

Keyword(s):

Drug Delivery ◽

Pulmonary Drug Delivery ◽

Regulatory Requirements ◽

Device Characterization ◽

Drug Deposition ◽

Delivery Mechanism ◽

Insight Into

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Sunitinib-Loaded Chondroitin Sulfate Hydrogels as a Novel Drug-Delivery Mechanism for the Treatment of Pancreatic Neuroendocrine Tumors

Annals of Surgical Oncology ◽

10.1245/s10434-021-10245-1 ◽

2021 ◽

Author(s):

Xavier M. Keutgen ◽

Kimberly J. Ornell ◽

Alyx Vogle ◽

Olga Lakiza ◽

Jelani Williams ◽

...

Keyword(s):

Drug Delivery ◽

Chondroitin Sulfate ◽

Neuroendocrine Tumors ◽

Pancreatic Neuroendocrine Tumors ◽

Delivery Mechanism ◽

Novel Drug

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RECENT NANOCOCHLEATE DRUG DELIVERY SYSTEM FOR CANCER TREATMENT: A REVIEW

International Journal of Current Pharmaceutical Research ◽

10.22159/ijcpr.2019v11i6.36359 ◽

2019 ◽

pp. 28-32

Author(s):

SUJIT NAYEK ◽

ABHIRAMI VENKATACHALAM ◽

SANGEETA CHOUDHURY

Keyword(s):

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

Divalent Cation ◽

Technology Use ◽

Oral Bioavailability ◽

Anticancer Agent ◽

Low Permeability ◽

Delivery Mechanism ◽

Low Solubility

Nanocochleates are at the forefront of the fast-growing nanotechnology sector in the delivery of drugs for cancer. This nanotechnology is the use of the cationic and anionic encapsulated drug that has poor oral bioavailability. Nanocochleate is a lipid-based drug delivery in the liposomal vesicles that is converted by calcium divalent cation into nanocochleate. Nanocochleates technology use encapsulations of the anticancer agent, which have low solubility, oral bioavailability and low permeability. This paper shows and provides an overview of the benefits of nanocochleates, drug delivery mechanism, choice of prevalent components (Phospholipids and Cations), various ways of producing nanocochleates and nanocochleate stability. Nanocochleates have far fewer constraints than other traditional carriers. To characterize nanocochleates, the suitable analytical methods are required. Therefore, in the therapy of cancer, nanocochleate becomes commonly applied and more prospective drug delivery system.

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