NIR-/pH-Responsive Drug Delivery of Functionalized Single-Walled Carbon Nanotubes for Potential Application in Cancer Chemo-Photothermal Therapy

2013 ◽  
Vol 30 (11) ◽  
pp. 2757-2771 ◽  
Author(s):  
Lei Wang ◽  
Jinjin Shi ◽  
Xin Jia ◽  
Ruiyuan Liu ◽  
Honghong Wang ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Potential Application ◽  
Photothermal Therapy ◽  
Single Walled Carbon Nanotubes ◽  
Ph Responsive ◽  
Single Walled Carbon ◽  
Walled Carbon Nanotubes

Unconventional and facile production of stimuli-responsive multifunctional system for simultaneous drug delivery and environmental remediation

2021 ◽  
Author(s):  
Narsimha Mamidi ◽  
Ramiro Manuel Velasco Delgadillo ◽  
Javier Villela Castrejón
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Environmental Remediation ◽  
Single Walled Carbon Nanotubes ◽  
Selective Removal ◽  
Stimuli Responsive ◽  
Ph Responsive ◽  
Single Walled Carbon ◽  
Fiber Membranes ◽  
Walled Carbon Nanotubes

Herein, pH-responsive poly 4-hydroxyphenyl methacrylated single-walled carbon nanotubes (PHPMA-SWCNT = f-CNT)/PE nanocomposite (NCST) fiber membranes were developed for stimuli drug delivery and the selective removal of Pb2+ and Cd2+ from...

Dispersing Single-Walled Carbon Nanotubes in Water by Adsorption of Polyphenols

2009 ◽  
Vol 620-622 ◽  
pp. 501-504
Author(s):  
Qiu Liao ◽  
Jing Sun ◽  
Lian Gao
Keyword(s):  
Carbon Nanotubes ◽  
Aromatic Compounds ◽  
Potential Application ◽  
Single Walled Carbon Nanotubes ◽  
Dispersion Interactions ◽  
Single Walled Carbon ◽  
Dispersion State ◽  
Ultrasonication Time ◽  
Walled Carbon Nanotubes

Single-walled carbon nanotubes (SWCNTs) were dispersed in water with the assistance of polyphenols (resorcinol and pyrogallol). SWCNTs have intrinsic tendency to adsorb aromatic compounds due to π-π dispersion interactions, which leads to SWCNTs noncovalently dispersed in water by adsorption of resorcinol or pyrogallol. The concentration of SWCNT suspension was determined by the absorbance value at 500 nm using UV-Vis spectrometer. The effects of polyphenol concentration and ultrasonication time on the dispersion state have been investigated. Resorcinol of 0.5 mg/mL was found to be most effective for solubilizing SWCNTs in water. Over 60 % of SWCNTs were well dispersed with ultrasonication time for 4 hours. However, SWCNTs were cut shorter and damages could be introduced with prolonged ultrasonication time. TEM images showed that SWCNT bundles became thinner with the presence of polyphenols. These aromatic compounds provide an effective way to disperse SWCNTs in water and might have potential application in nanocomposite preparation.

scholarly journals Spontaneous directional motion of water molecules in single-walled carbon nanotubes with a stiffness gradient

2019 ◽  
Vol 1 (3) ◽  
pp. 1175-1180 ◽  
Author(s):  
Shuai Chen ◽  
Yuan Cheng ◽  
Gang Zhang ◽  
Yong-Wei Zhang
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Water Treatment ◽  
Water Splitting ◽  
Molecular Motion ◽  
Single Walled Carbon Nanotubes ◽  
Water Molecules ◽  
Single Walled Carbon ◽  
Directional Motion ◽  
Walled Carbon Nanotubes

Controlling water molecular motion at the nanoscale is critical for many important applications, such as water splitting to produce hydrogen and oxygen, biological and chemical cell reactions, nanofluidics, drug delivery, water treatment, etc.

Demonstration of biocompatibility of single walled carbon nanotubes with blood leukocytes

2012 ◽  
Vol 1416 ◽  
Author(s):  
Krishnakiran Medepalli ◽  
Bruce Alphenaar ◽  
Ashok Raj ◽  
Palaniappan Sethu
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Immune Response ◽  
Single Walled Carbon Nanotubes ◽  
Cancer Diagnostics ◽  
Indirect Interaction ◽  
Activation Markers ◽  
Single Walled Carbon ◽  
Structural And Functional Properties ◽  
Walled Carbon Nanotubes

ABSTRACTSingle walled carbon nanotubes (SWNTs) possess unique structural and functional properties. Their ability to be functionalized with different biomolecules makes them excellent candidates for biomedical applications like targeted drug delivery and cancer diagnostics. However, prior to use in therapeutic applications, biocompatibility of SWNTs needs to be thoroughly investigated. Blood is a living tissue and contains cells which can potentially interact with SWNTs during the drug delivery process. The interaction of leukocytes in blood with the SWNTs can provide information regarding the immune response of the host to the nanotubes. Here, we evaluated the acute immune response of leukocytes in blood to SWNTs via (a) direct interaction, due to the presence of SWNTs in circulation and (b) indirect interaction, due to the presentation of SWNTs to leukocytes via antigen presenting cells. These SWNTs were non-covalently functionalized with single stranded DNA (ss-DNA) that acts as a surfactant for suspending SWNTs in aqueous solutions and also serves as a backbone for attaching and transporting different biomolecules. Isolation of cells from blood was done using density gradient centrifugation. Early activation markers were used to study the activation of different leukocyte subpopulations and any activation results in changes of these markers. Flow cytometry was done to analyze the different subpopulations. Results of our study demonstrated that ss-DNA functionalized SWNTs do not elicit an immune response from leukocytes in blood via direct or indirect interaction. This intensive study demonstrates the biocompatibility of single walled carbon nanotubes and paves the way for their safe use in drug delivery and cancer therapeutics without cytotoxicity.

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