Polyampholyte-grafted single walled carbon nanotubes prepared via a green process for anticancer drug delivery application

Polymer ◽  
2020 ◽  
Vol 193 ◽  
pp. 122340
Author(s):  
Quoc Thang Phan ◽  
Maheshkumar Prakash Patil ◽  
Trang T.K. Tu ◽  
Cuong M.Q. Le ◽  
Gun-Do Kim ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Anticancer Drug ◽  
Single Walled Carbon Nanotubes ◽  
Green Process ◽  
Single Walled Carbon ◽  
Drug Delivery Application ◽  
Anticancer Drug Delivery ◽  
Walled Carbon Nanotubes

scholarly journals Self-Assembled Supramolecular Ribbon-Like Structures Complexed to Single Walled Carbon Nanotubes as Possible Anticancer Drug Delivery Systems

2019 ◽  
Vol 20 (9) ◽  
pp. 2064 ◽  
Author(s):  
Anna Jagusiak ◽  
Katarzyna Chłopaś ◽  
Grzegorz Zemanek ◽  
Małgorzata Jemioła-Rzemińska ◽  
Barbara Piekarska ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Anticancer Drug ◽  
Triple System ◽  
Single Walled Carbon Nanotubes ◽  
Drug Binding ◽  
Single Walled Carbon ◽  
Anticancer Drug Delivery ◽  
Self Assembled ◽  
Walled Carbon Nanotubes

Designing an effective targeted anticancer drug delivery method is still a big challenge, since chemotherapeutics often cause a variety of undesirable side effects affecting normal tissues. This work presents the research on a novel system consisting of single walled carbon nanotubes (SWNT), dispersed with Congo Red (CR), a compound that forms self-assembled ribbon-like structures (SRLS) and anticancer drug doxorubicin (DOX). SWNT provide a large surface for binding of planar aromatic compounds, including drugs, while CR supramolecular ribbon-like assemblies can be intercalated by drugs, like anthracycline rings containing DOX. The mechanism of interactions in SWNT–CR–DOX triple system was proposed based on electrophoretic, spectral, Dynamic Light Scattering and scanning electron microscopy analyzes. The profile of drug release from the investigated system was evaluated using dialysis and Differential Scanning Calorimetry. The results indicate that ribbon-like supramolecular structures of CR bind to SWNT surface forming SWNT–CR complexes which finally bind DOX. The high amount of nanotube-bound CR greatly increases the capacity of the carrier for the drug. The high capacity for drug binding and possible control of its release (through pH changes) in the analyzed system may result in prolonged and localized drug action. The proposed SWNT–CR–DOX triple system meets the basic criteria that justifies its further research as a potential drug carrier.

scholarly journals Spontaneous directional motion of water molecules in single-walled carbon nanotubes with a stiffness gradient

2019 ◽  
Vol 1 (3) ◽  
pp. 1175-1180 ◽  
Author(s):  
Shuai Chen ◽  
Yuan Cheng ◽  
Gang Zhang ◽  
Yong-Wei Zhang
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Water Treatment ◽  
Water Splitting ◽  
Molecular Motion ◽  
Single Walled Carbon Nanotubes ◽  
Water Molecules ◽  
Single Walled Carbon ◽  
Directional Motion ◽  
Walled Carbon Nanotubes

Controlling water molecular motion at the nanoscale is critical for many important applications, such as water splitting to produce hydrogen and oxygen, biological and chemical cell reactions, nanofluidics, drug delivery, water treatment, etc.

Demonstration of biocompatibility of single walled carbon nanotubes with blood leukocytes

2012 ◽  
Vol 1416 ◽  
Author(s):  
Krishnakiran Medepalli ◽  
Bruce Alphenaar ◽  
Ashok Raj ◽  
Palaniappan Sethu
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Immune Response ◽  
Single Walled Carbon Nanotubes ◽  
Cancer Diagnostics ◽  
Indirect Interaction ◽  
Activation Markers ◽  
Single Walled Carbon ◽  
Structural And Functional Properties ◽  
Walled Carbon Nanotubes

ABSTRACTSingle walled carbon nanotubes (SWNTs) possess unique structural and functional properties. Their ability to be functionalized with different biomolecules makes them excellent candidates for biomedical applications like targeted drug delivery and cancer diagnostics. However, prior to use in therapeutic applications, biocompatibility of SWNTs needs to be thoroughly investigated. Blood is a living tissue and contains cells which can potentially interact with SWNTs during the drug delivery process. The interaction of leukocytes in blood with the SWNTs can provide information regarding the immune response of the host to the nanotubes. Here, we evaluated the acute immune response of leukocytes in blood to SWNTs via (a) direct interaction, due to the presence of SWNTs in circulation and (b) indirect interaction, due to the presentation of SWNTs to leukocytes via antigen presenting cells. These SWNTs were non-covalently functionalized with single stranded DNA (ss-DNA) that acts as a surfactant for suspending SWNTs in aqueous solutions and also serves as a backbone for attaching and transporting different biomolecules. Isolation of cells from blood was done using density gradient centrifugation. Early activation markers were used to study the activation of different leukocyte subpopulations and any activation results in changes of these markers. Flow cytometry was done to analyze the different subpopulations. Results of our study demonstrated that ss-DNA functionalized SWNTs do not elicit an immune response from leukocytes in blood via direct or indirect interaction. This intensive study demonstrates the biocompatibility of single walled carbon nanotubes and paves the way for their safe use in drug delivery and cancer therapeutics without cytotoxicity.

Preferred Position and Orientation of Anticancer Drug Cisplatin During Encapsulation Into Single-Walled Carbon Nanotubes

2012 ◽  
Vol 3 (1) ◽  
Author(s):  
R. Ansari ◽  
E. Kazemi ◽  
E. Mahmoudinezhad ◽  
F. Sadeghi
Keyword(s):  
Carbon Nanotubes ◽  
Side Effects ◽  
Anticancer Drug ◽  
Equilibrium Condition ◽  
Hybrid Approach ◽  
Single Walled Carbon Nanotubes ◽  
Drug Carriers ◽  
Single Walled Carbon ◽  
Chemotherapy Drugs ◽  
Walled Carbon Nanotubes

Cisplatin is one of the most widely prescribed chemotherapy drugs to treat different types of cancers. However, this anticancer drug has a number of side effects such as kidney and nerve damages, anaphylactic reactions, hearing loss, nausea, and vomiting that strongly restrict its function. In the present study, single-walled carbon nanotubes (SWCNTs) are used as protective drug carriers which can decrease these severe side effects to some extent. Using the hybrid discrete-continuum model in conjunction with Lennard-Jones potential, new semi-analytical expressions in terms of single integrals are given to evaluate van der Waals (vdW) potential energy and interaction force between an offset cisplatin and a SWCNT. In addition, molecular dynamics (MD) simulations are conducted to validate the results of such a hybrid approach. The preferred location and orientation of cisplatin while entering SWCNTs are determined. It is shown that the equilibrium condition of the drug may be affected by the radius of nanotube, the orientation of cisplatin, and the distance between the central molecule of the drug (Pt) and the left end of nanotube. Furthermore, the influence of equilibrium condition on the distributions of vdW interactions is investigated.

scholarly journals Single-Walled Carbon Nanotubes Mediated Neovascularity Targeted Antitumor Drug Delivery System

2013 ◽  
Vol 16 (1) ◽  
pp. 40 ◽  
Author(s):  
Chengqun Chen ◽  
Huijuan Zhang ◽  
Lin Hou ◽  
Jinjin Shi ◽  
Lei Wang ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Single Walled Carbon Nanotubes ◽  
Antitumor Drug ◽  
Mice Model ◽  
Single Walled Carbon ◽  
Walled Carbon Nanotubes

Purpose. The aim of this study was to prepare a new neovascularity targeting antitumor drug delivery system mediated by single-walled carbon nanotubes (SWNTs). Methods. In this study, antiangiogenesis agent 2-methoxyestradiol was loaded by SWNTs via π~π accumulation. The SWNTs were then linked with NGR (Asn-Gly-Arg) peptide, which could target tumor angiogenesis. This drug delivery system was characterized by transmission electron microscope, scanning electron microscopy, and atomic force microscope analysis. The suppression efficacy of tumor growth in cultured breast cancer cell line was evaluated by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. The in vivo antitumor activity was evaluated on the Sarcoma (S180) tumor-bearing mice model. Results. The characteristics of this drug delivery system showed that the particle of complex was 190 ± 4.3 nm in size distribution and 23.56 ± 2.03 mV in zeta potential. The inhibition ratio of this SWNTs drug delivery system at 24, 48, and 72 h was about 57.7%, 83.6%, and 88.2%. Compared with normal saline group, the relative tumor volumes in the 2ME, SWNTs-2ME, and NGR-SWNTs-2ME groups were decreased 1 week after administration. Conclusion. This novel neovascularity targeting drug delivery system containing NGR-SWNTs-2ME may be beneficial to improve treatment efficacy and minimize side effects in future cancer therapy. This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.

Sign in / Sign up

Export Citation Format

Share Document