Monodistearoylphosphatidylethanolamine-hyaluronic acid functionalization of single-walled carbon nanotubes for targeting intracellular drug delivery to overcome multidrug resistance of cancer cells

Carbon ◽  
2016 ◽  
Vol 96 ◽  
pp. 362-376 ◽  
Author(s):  
Hong Juan Yao ◽  
Lan Sun ◽  
Yan Liu ◽  
Shuang Jiang ◽  
Yunzhu Pu ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Hyaluronic Acid ◽  
Multidrug Resistance ◽  
Cancer Cells ◽  
Single Walled Carbon Nanotubes ◽  
Single Walled Carbon ◽  
Intracellular Drug Delivery ◽  
Walled Carbon Nanotubes

Controlled release and targeted delivery to cancer cells of doxorubicin from polysaccharide-functionalised single-walled carbon nanotubes

2015 ◽  
Vol 3 (9) ◽  
pp. 1846-1855 ◽  
Author(s):  
Yunfei Mo ◽  
Haowen Wang ◽  
Jianghui Liu ◽  
Yong Lan ◽  
Rui Guo ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Controlled Release ◽  
Cancer Cells ◽  
Targeted Delivery ◽  
Water Solubility ◽  
Single Walled Carbon Nanotubes ◽  
Innovative Drug ◽  
Single Walled Carbon ◽  
Walled Carbon Nanotubes

Carboxyl single-walled carbon nanotubes (SWNTs) were used to construct an innovative drug delivery system by modification with chitosan (CHI) to enhance water solubility and biocompatibility.

scholarly journals Spontaneous directional motion of water molecules in single-walled carbon nanotubes with a stiffness gradient

2019 ◽  
Vol 1 (3) ◽  
pp. 1175-1180 ◽  
Author(s):  
Shuai Chen ◽  
Yuan Cheng ◽  
Gang Zhang ◽  
Yong-Wei Zhang
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Water Treatment ◽  
Water Splitting ◽  
Molecular Motion ◽  
Single Walled Carbon Nanotubes ◽  
Water Molecules ◽  
Single Walled Carbon ◽  
Directional Motion ◽  
Walled Carbon Nanotubes

Controlling water molecular motion at the nanoscale is critical for many important applications, such as water splitting to produce hydrogen and oxygen, biological and chemical cell reactions, nanofluidics, drug delivery, water treatment, etc.

Demonstration of biocompatibility of single walled carbon nanotubes with blood leukocytes

2012 ◽  
Vol 1416 ◽  
Author(s):  
Krishnakiran Medepalli ◽  
Bruce Alphenaar ◽  
Ashok Raj ◽  
Palaniappan Sethu
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Immune Response ◽  
Single Walled Carbon Nanotubes ◽  
Cancer Diagnostics ◽  
Indirect Interaction ◽  
Activation Markers ◽  
Single Walled Carbon ◽  
Structural And Functional Properties ◽  
Walled Carbon Nanotubes

ABSTRACTSingle walled carbon nanotubes (SWNTs) possess unique structural and functional properties. Their ability to be functionalized with different biomolecules makes them excellent candidates for biomedical applications like targeted drug delivery and cancer diagnostics. However, prior to use in therapeutic applications, biocompatibility of SWNTs needs to be thoroughly investigated. Blood is a living tissue and contains cells which can potentially interact with SWNTs during the drug delivery process. The interaction of leukocytes in blood with the SWNTs can provide information regarding the immune response of the host to the nanotubes. Here, we evaluated the acute immune response of leukocytes in blood to SWNTs via (a) direct interaction, due to the presence of SWNTs in circulation and (b) indirect interaction, due to the presentation of SWNTs to leukocytes via antigen presenting cells. These SWNTs were non-covalently functionalized with single stranded DNA (ss-DNA) that acts as a surfactant for suspending SWNTs in aqueous solutions and also serves as a backbone for attaching and transporting different biomolecules. Isolation of cells from blood was done using density gradient centrifugation. Early activation markers were used to study the activation of different leukocyte subpopulations and any activation results in changes of these markers. Flow cytometry was done to analyze the different subpopulations. Results of our study demonstrated that ss-DNA functionalized SWNTs do not elicit an immune response from leukocytes in blood via direct or indirect interaction. This intensive study demonstrates the biocompatibility of single walled carbon nanotubes and paves the way for their safe use in drug delivery and cancer therapeutics without cytotoxicity.

scholarly journals Single-Walled Carbon Nanotubes Mediated Neovascularity Targeted Antitumor Drug Delivery System

2013 ◽  
Vol 16 (1) ◽  
pp. 40 ◽  
Author(s):  
Chengqun Chen ◽  
Huijuan Zhang ◽  
Lin Hou ◽  
Jinjin Shi ◽  
Lei Wang ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Single Walled Carbon Nanotubes ◽  
Antitumor Drug ◽  
Mice Model ◽  
Single Walled Carbon ◽  
Walled Carbon Nanotubes

Purpose. The aim of this study was to prepare a new neovascularity targeting antitumor drug delivery system mediated by single-walled carbon nanotubes (SWNTs). Methods. In this study, antiangiogenesis agent 2-methoxyestradiol was loaded by SWNTs via π~π accumulation. The SWNTs were then linked with NGR (Asn-Gly-Arg) peptide, which could target tumor angiogenesis. This drug delivery system was characterized by transmission electron microscope, scanning electron microscopy, and atomic force microscope analysis. The suppression efficacy of tumor growth in cultured breast cancer cell line was evaluated by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. The in vivo antitumor activity was evaluated on the Sarcoma (S180) tumor-bearing mice model. Results. The characteristics of this drug delivery system showed that the particle of complex was 190 ± 4.3 nm in size distribution and 23.56 ± 2.03 mV in zeta potential. The inhibition ratio of this SWNTs drug delivery system at 24, 48, and 72 h was about 57.7%, 83.6%, and 88.2%. Compared with normal saline group, the relative tumor volumes in the 2ME, SWNTs-2ME, and NGR-SWNTs-2ME groups were decreased 1 week after administration. Conclusion. This novel neovascularity targeting drug delivery system containing NGR-SWNTs-2ME may be beneficial to improve treatment efficacy and minimize side effects in future cancer therapy. This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.

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