1H NMR-Based Metabolomics Approach in Investigating the Chemical Profile, Antioxidant and Anti-Inflammatory Activities of Gynura procumbens and Cleome gynandra

2020 ◽  
Vol 75 (2) ◽  
pp. 243-251 ◽  
Author(s):  
Machap Chandradevan ◽  
Sanimah Simoh ◽  
Ahmed Mediani ◽  
Intan Safinar Ismail ◽  
Faridah Abas
Keyword(s):  
1H Nmr ◽  
Chemical Profile ◽  
Cleome Gynandra ◽  
Anti Inflammatory

Chemical profile, antioxidant and anti-inflammatory properties of Miconia albicans (Sw.) Triana (Melastomataceae) fruits extract

2021 ◽  
pp. 113979
Author(s):  
José G. de S. Corrêa ◽  
Mirelli Bianchin ◽  
Ana Paula Lopes ◽  
Evandro Silva ◽  
Franciele Q. Ames ◽  
...  
Keyword(s):  
Chemical Profile ◽  
Anti Inflammatory

scholarly journals Synthesis, Characterization and Evaluation of Anti-inflammatory Activity of Novel Indoline Derivatives

2016 ◽  
Vol 12 (12) ◽  
pp. 4557-4563
Author(s):  
Dhinesh kumar Manoharan
Keyword(s):  
1H Nmr ◽  
13C Nmr ◽  
Protein Denaturation ◽  
Inflammatory Activity ◽  
Potent Inhibition ◽  
Ft Ir ◽  
Anti Inflammatory

Series of indoline derivatives were synthesized using N-(4-aminophenyl) indoline-1-carbothiamide as a precursor. The structures of synthesized compounds were confirmed by   FT-IR, 1H-NMR, 13C-NMR and LC-MS. The in vitro anti-inflammatory activity of synthesized indoline derivatives were examined by standard anti-denaturation assay. The compounds 4a (IC50 = 62.2 µg/ml) and 4b (IC50 = 60.7 µg/ml) showed potent inhibition on protein denaturation. The compounds 5a (IC50 = 97.8 µg/ml) exhibits moderate inhibition on protein denaturation

SYNTHESIS AND EVALUATION OF SOME NOVEL TRIAZOLO BETA-LACTAM DERIVATIVES FOR THEIR ANTI-INFLAMMATORY ACTIVITY

INDIAN DRUGS ◽  
2014 ◽  
Vol 51 (01) ◽  
pp. 48-54
Author(s):  
◽  
N.B Wable ◽  
D.S Musmade ◽  
V. B. Gawali ◽  
J. S. Pattan ◽  
...  
Keyword(s):  
1H Nmr ◽  
Inflammatory Activity ◽  
Beta Lactam ◽  
Standard Drug ◽  
Anti Inflammatory

A series of substituted triazole based β-Lactam derivatives were synthesized. The structures of the synthesized compounds were characterized and confirmed by IR, 1H- NMR and CHN analysis. The synthesized compounds were evaluated for their anti-inflammatory activity. All the compounds have shown promising anti-inflammatory activity when compared with standard drug Ibuprofen.

scholarly journals Standardization of Solvent Extracts from Onopordum acanthium Fruits by GC-MS, HPLC-UV/DAD, HPLC-TQMS and 1H-NMR and Evaluation of their Inhibitory Effects on the Expression of IL-8 and E-selectin in Immortalized Endothelial Cells (HUVECtert)

2014 ◽  
Vol 9 (7) ◽  
pp. 1934578X1400900
Author(s):  
Armond Daci ◽  
Markus Gold-Binder ◽  
Davide Garzon ◽  
Alessio Patea ◽  
Giangiacomo Beretta
Keyword(s):  
1H Nmr ◽  
1H Nmr Spectroscopy ◽  
Inhibitory Effects ◽  
Traditional Medicines ◽  
Inflammatory Agent ◽  
Onopordum Acanthium ◽  
Tnf Α ◽  
Study Support ◽  
Anti Inflammatory ◽  
Dose Dependent

In this work we have characterized and standardized the solvent extracts of the fruits of Onopordum acanthium, a plant widely distributed from Europe to Asia and used in different traditional medicines. Fruits were extracted with methanol (ME) and n-hexane (HE) and the extract compositions determined by GC-MS, HPLC-UV/DAD, HPLC-TQMS and 1H NMR spectroscopy. Anti-inflammatory activity (IL-8 and E-selectin, qPCR and ELISA) was investigated in HUVECtert cells stimulated with TNF-α and LPS. Arctiin and isochlorogenic acid were found in ME (87±2%, w/w, and 10.2±0.2%, w/w; 38.0±3.2 mg/gFRUITS and 3.5 ± 0.4 mg/gFRUITS) and (ii) paraffins in the HE (195.6 ± 5.6 mg/g). A dose dependent (from 15 to 40 μgME/mL corresponding to 20–75 μM arctiin) inhibition of E-selectin and of the induction of IL-8 was induced by LPS. The results of this study support the use of O. acanthium fruits in traditional medicine as an anti-inflammatory agent and for cancer prevention and treatment.

scholarly journals Synthesis, Characterization and evaluation of Anti-inflammatory and Analgesic activity of Benzothiazole derivatives

2014 ◽  
Vol 2 (03) ◽  
pp. 84-89 ◽  
Author(s):  
Abhay Kumar Verma ◽  
Alex Martin ◽  
Arun Kumar Singh
Keyword(s):  
Benzoic Acid ◽  
1H Nmr ◽  
Mass Spectroscopy ◽  
Analgesic Activity ◽  
Aromatic Aldehydes ◽  
Spectroscopic Methods ◽  
Schiff’S Bases ◽  
Benzothiazole Derivatives ◽  
Anti Inflammatory ◽  
Analgesic Activities

A parent benzothiazole nucleus was synthesized by para amino acetanilide, then it is subjected to treatment with various substituted aromatic aldehydes to get the corresponding Schiff’s bases followed by treatment with pthalic anhydride to form 2-(6- acetamidobenzo[d]thiazol-2-ylcarbamoyl)benzoic acid. The structures of synthesized compounds were confirmed by various spectroscopic methods such as IR, 1H NMR and mass spectroscopy. The products were evaluated for their anti-inflammatory and analgesic activities. Some of the compounds exhibited potent activities when compared with the standards.

scholarly journals Quinazoline-containing Hydrazydes of Dicarboxylic Acids and Products of Their Structural Modification: A Novel Class of Anti-inflammatory Agents

2021 ◽  
Vol 68 (2) ◽  
pp. 395-403
Author(s):  
Nataliia Krasovska ◽  
Viktor Stavytskyi ◽  
Inna Nosulenko ◽  
Oleksandr Karpenko ◽  
Oleksii Voskoboinik ◽  
...  
Keyword(s):  
Chemical Modification ◽  
Spectral Data ◽  
1H Nmr ◽  
Structural Modification ◽  
Dicarboxylic Acids ◽  
Inflammatory Activity ◽  
Mass Spectral Data ◽  
Mass Spectral ◽  
Anti Inflammatory ◽  
Amide Fragment

The synthesis of hydrazides formed by quinazolin-4(3H)-ylidenehydrazine and dicarboxylic acids, as well as their further modification are described in the present manuscript. It was shown that above-mentioned hydrazides may be obtained via acylation of initial quinazolin-4(3H)-ylidenehydrazine by corresponding acylhalides, cyclic anhydrides and imidazolides of dicarboxylic acids monoesters. Obtained hydrazides were converted into [1,2,4]triazolo[1,5-с]quinazolines that were used as initial compounds for chemical modification aimed to the introduction of amide fragment to the molecule. The IR, 1H NMR and chromato-mass spectral data of obtained compounds were studied and discussed. Obtained substances were studied for anti-inflammatory activity using carrageenan-induced paw inflammation model. Amides of ([1,2,4]triazolo[1,5-с]quinazoline-2-yl)alkyl carboxylic acids were detected as promising class of anti-inflammatory agents for further purposeful synthesis and profound study of anti-inflammatory activity.

scholarly journals Chemical constituents of Pseudobrickellia brasiliensis leaves(Spreng.) R.M. King & H. Rob. (Asteraceae)

2016 ◽  
Vol 18 (2) ◽  
pp. 408-414 ◽  
Author(s):  
M.L.L. DE AMORIM ◽  
W.M. GODINHO ◽  
F.C. ARCHANJO ◽  
C.F.F. GRAEL
Keyword(s):  
1H Nmr ◽  
13C Nmr ◽  
Chemical Constituents ◽  
Inflammatory Activity ◽  
Anti Inflammatory

ABSTRACT Pseudobrickelliabrasiliensisis aspecies endemic toBrazil, popularlyknown as “arnica”/ “arnica-do-campo”/ “arnica-do-mato” and used for itsanalgesicand anti-inflammatoryproperties. The objective of this research was thephytochemical studyof the essential oilandhexaneandethyl acetateextracts of the leaves of this species. The essential oilwasextracted byhydrodistillation using a Clevengerapparatusand was analyzed byGC/MS, 25components were identified, with a predominance ofmonoterpenes. The extractswere subjected toclassicalchromatographyand the fractionswere analyzed byGC/MS, 1D 1H-NMR, 13C-NMR and 13C-NMR-DEPT 135.α-amyrin, α-amyrin acetate, β-amyrin, β-amyrin acetate, lupeol, lupeolacetate, pseudotaraxasterol andtaraxasterol (triterpenes), andkaurenoicacid (diterpene) were identified.Theseterpenesarechemo-taxonomicallyrelated to theEupatorieaetribe(Asteraceae) and may be responsible for the anti-inflammatory activity attributed to the plant.

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