scholarly journals Norwegian population norms for the EQ-5D-5L: results from a general population survey

2021 ◽  
Author(s):  
Andrew Malcolm Garratt ◽  
Tonya Moen Hansen ◽  
Liv Ariane Augestad ◽  
Kim Rand ◽  
Knut Stavem
Keyword(s):  
General Population ◽  
Age Groups ◽  
Education Level ◽  
Population Characteristics ◽  
Population Norms ◽  
General Decline ◽  
National Quality ◽  
Patient Reported ◽  
Vas Scores ◽  
Eq Vas

Abstract Purpose To provide the first Norwegian EQ-5D-5L and EQ VAS population norms for the adult general population. Methods Postal survey of a random sample of 12,790 Norwegians identified through the National Registry of the Norwegian Tax Administration. Norms, weighted for Norwegian general population characteristics, are shown for the five EQ-5D-5L dimensions, EQ-5D index, and EQ VAS scores for seven age categories, females, males, and education level. Results There were 3200 (25.9%) respondents to 12,263 correctly addressed questionnaires. The EQ-5D-5L dimensions, EQ VAS, and background questions were completed by 3120 (24.6%) respondents. The mean age (SD) was 50.9 (21.7) and range was 18–97 years. The youngest age group of 18–29 years and oldest of 80 years and over had the highest (n = 691) and lowest (n = 239) number of respondents, respectively. Compared to the general population, the respondents comprised a greater number of females, younger and older ages, and had a higher education level. 32% of respondents reported no health problems on the EQ-5D-5L. From the youngest to oldest age groups, there was a general decline in health as assessed by the EQ-5D-5L. The exception was for anxiety/depression, where the youngest age groups had the poorest health. Apart from self-care, women reported poorer health than men, as assessed by the EQ-5D-5L; EQ VAS scores were similar for men and women. Higher levels of health (EQ-5D index, EQ VAS scores) were found with increasing levels of education. Conclusion The population norms will improve interpretation of EQ-5D-5L and EQ VAS scores in Norwegian applications including clinical practice, clinical and health services research, and national quality registers where EQ-5D-5L is the most widely used patient-reported instrument.

scholarly journals Norwegian Population Norms for the EQ-5D-5L: Results From a General Population Survey

2021 ◽  
Author(s):  
Andrew Malcolm Garratt ◽  
Tonya Moen Hansen ◽  
Liv Ariane Augestad ◽  
Kim Rand ◽  
Knut Stavem
Keyword(s):  
General Population ◽  
Age Groups ◽  
Education Level ◽  
Services Research ◽  
Population Norms ◽  
General Decline ◽  
National Quality ◽  
Patient Reported ◽  
Vas Scores ◽  
Eq Vas

Abstract Purpose: To provide the first Norwegian EQ-5D-5L and EQ VAS population norms for the adult general population. Methods: Postal survey of a random sample of 12,790 Norwegians identified through the National Registry of the Norwegian Tax Administration. Norms are shown for the five EQ-5D-5L dimensions, EQ-5D index and EQ VAS scores for seven age categories, males, females and education level. Results: There were 3,200 (25.9%) respondents to 12,263 correctly addressed questionnaires. The EQ-5D-5L dimensions, EQ VAS and background questions were completed by 3,120 (24.6%) respondents. The mean age (SD) was 50.9 (21.7); range 18 to 97 years. The youngest age group of 18-29 years and oldest of 80 years and over had the highest (n=691) and lowest (n=239) number of respondents respectively. Compared to the general population, the respondents comprised a greater number of females, younger and older ages, and had a higher education level. 32% of respondents reported no health problems on the EQ-5D-5L. From the youngest to oldest age groups, there was a general decline in health as assessed by the EQ-5D-5L. The exception was for anxiety/depression, where the youngest age groups had the poorest health. Apart from self-care, women reported poorer health than men, as assessed by the EQ-5D-5L; EQ VAS scores were similar for men and women. Higher levels of health (EQ-5D index, EQ VAS scores) were found with increasing levels of education. Conclusion: The population norms will improve interpretation of EQ-5D-5L and EQ VAS scores in Norwegian applications including clinical practice, clinical and health services research, and national quality registers where EQ-5D-5L is the most widely used patient-reported instrument.

scholarly journals Longitudinal study of patients’ health-related quality of life using EQ-5D-3L in 11 Swedish National Quality Registers

BMJ Open ◽  
2022 ◽  
Vol 12 (1) ◽  
pp. e048176
Author(s):  
Fitsum Sebsibe Teni ◽  
Ola Rolfson ◽  
Nancy Devlin ◽  
David Parkin ◽  
Emma Nauclér ◽  
...  
Keyword(s):  
General Population ◽  
Secondary Outcome ◽  
Vas Score ◽  
National Quality ◽  
Patient Reported ◽  
Hand Fracture ◽  
Patient Groups ◽  
Vas Scores ◽  
Eq Vas

ObjectiveTo compare problems reported in the five EQ-5D-3L dimensions and EQ VAS scores at baseline and at 1-year follow-up among different patient groups and specific diagnoses in 11 National Quality Registers (NQRs) and to compare these with the general population.DesignLongitudinal, descriptive study.Participants2 66 241 patients from 11 NQRs and 49 169 participants from the general population were included in the study.Primary and secondary outcome measuresProportions of problems reported in the five EQ-5D-3L dimensions, EQ VAS scores of participants’ own health and proportions of participants and mean/median EQ VAS score in the Paretian Classification of Health Change (PCHC) categories.ResultsIn most of the included registers, and the general population, problems with pain/discomfort were the most frequently reported at baseline and at 1-year follow-up. Mean EQ VAS score (SD) ranged from 45.2 (22.4) among disc hernia patients to 88.1 (15.3) in wrist and hand fracture patients at baseline. They ranged from 48.9 (20.9) in pulmonary fibrosis patients to 83.3 (17.4) in wrist and hand fracture patients at follow-up. The improved category of PCHC, improvement in at least one dimension without deterioration in any other, accounted for the highest proportion in several diagnoses, corresponding with highest improvement in mean EQ VAS score.ConclusionsThe study documented self-reported health of several different patient groups using the EQ-5D-3L in comparing with the general population. This demonstrated the important role of patient-reported outcomes in routine clinical care, to assess and follow-up health status and progress within different groups of patients. The EQ-5D-3L descriptive system and EQ VAS have an important role in providing a ‘common denominator’, allowing comparisons across NQRs and specific diagnoses.Trial registration numberClinicalTrials.gov (NCT04359628).

scholarly journals Variations in Patients’ Overall Assessment of Their Health Across and Within Disease Groups Using the EQ-5D Questionnaire: Protocol for a Longitudinal Study in the Swedish National Quality Registers

10.2196/27669 ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. e27669
Author(s):  
Fitsum Sebsibe Teni ◽  
Ola Rolfson ◽  
Nancy Devlin ◽  
David Parkin ◽  
Emma Nauclér ◽  
...  
Keyword(s):  
General Population ◽  
Data Retrieval ◽  
Health State ◽  
Health States ◽  
National Quality ◽  
Patient Reported ◽  
Patient Groups ◽  
Value Sets ◽  
Eq Vas

Background EQ-5D is one of the most commonly used questionnaires to measure health-related quality of life. It is included in many of the Swedish National Quality Registers (NQRs). EQ-5D health states are usually summarized using “values” obtained from members of the general public, a majority of whom are healthy. However, an alternative, which remains to be studied in detail, is the potential to use patients’ self-reported overall health on the visual analog scale (VAS) as a means of capturing experience-based perspective. Objective The aim of this study is to assess EQ VAS as a valuation method with an experience-based perspective through comparison of its performance across and within patient groups, and with that of the general population in Sweden. Methods Data on nearly 700,000 patients from 12 NQRs covering a variety of diseases/conditions and nearly 50,000 individuals from the general population will be analyzed. The EQ-5D-3L data from the 12 registers and EQ-5D-5L data from 2 registers will be used in the analyses. Longitudinal studies of patient-reported outcomes among different patient groups will be conducted in the period from baseline to 1-year follow-up. Descriptive statistics and analyses comparing EQ-5D dimensions and observed self-assessed EQ VAS values across and within patient groups will be performed. Comparisons of the change in health state and observed EQ VAS values at 1-year follow-up will also be undertaken. Regression models will be used to assess whether EQ-5D dimensions predict observed EQ VAS values to investigate patient value sets in each patient group. These will be compared across the patient groups and with the existing Swedish experience-based VAS and time trade-off value sets obtained from the general population. Results Data retrieval started in May 2019 and data of patients in the 12 NQRs and from the survey conducted among the general population have been retrieved. Data analysis is ongoing on the retrieved data. Conclusions This research project will provide information on the differences across and within patient groups in terms of self-reported health status through EQ VAS and comparison with the general population. The findings of the study will contribute to the literature by exploring the potential of self-assessed EQ VAS values to develop value sets using an experience-based perspective. Trial Registration ClinicalTrials.gov NCT04359628; https://clinicaltrials.gov/ct2/show/NCT04359628. International Registered Report Identifier (IRRID) DERR1-10.2196/27669

scholarly journals Reference data among general population and known-groups validity among hypertensive population of the EQ-5D-5L in Vietnam

2021 ◽  
Author(s):  
Vu Quynh Mai ◽  
Kim Bao Giang ◽  
Hoang Van Minh ◽  
Lars Lindholm ◽  
Sun Sun ◽  
...  
Keyword(s):  
General Population ◽  
Group Testing ◽  
Age Groups ◽  
Obese People ◽  
Five Dimensions ◽  
Population Norms ◽  
Hypertensive Group ◽  
The Mean ◽  
Body Mass Indexes ◽  
Eq Vas

Abstract Purpose This study aims to provide EQ-5D-5L population norms among the general population in Vietnam and to test EQ-5D-5L’ construction validity among people living with hypertension there. Methods Descriptive statistics of the five dimensions and five levels, EQ-VAS and EQ-5D-5L indexes were categorised into gender and age groups for the EQ-5D-5L population norms. Known-groups testing was set for lower EQ-5D-5L outcomes among people who were aware of their hypertensive status, females, people with more comorbidities, less education, older ages, and higher body mass indexes. Level of confident interval was 95%. Results The mean EQ-VAS and EQ-5D-5L indexes were 81.10 (SD: 13.35) and 0.94 (SD: 0.09) among the general population. The EQ-5D-5L outcomes were better among younger people, males, people with more education, employees, and single people. Respondents reported fewer problems with self-care and usual activities and tend to have problems at higher levels across older ages. The known-group testing showed statistically significant results. The mean EQ-VAS and EQ-5D-5L indexes of people in the diagnosed hypertensive group (71.48 and 0.94, respectively) were statistically significantly smaller than they were in the non-hypertensive and undiagnosed hypertensive group (76.65 and 0.97; 76.95 and 0.96 accordingly). Statistically significant associations of lower EQ-5D-5L indexes and EQ-VAS were found among people diagnosed for hypertension, people suffering from an incremental comorbidity, and obese people. Conclusion This study has provided EQ-5D-5L population norms for the general population and evidence for known-groups validity of the EQ-5D-5L instrument among hypertensive people in Vietnam.

scholarly journals Variations in Patients’ Overall Assessment of Their Health Across and Within Disease Groups Using the EQ-5D Questionnaire: Protocol for a Longitudinal Study in the Swedish National Quality Registers (Preprint)

2021 ◽  
Author(s):  
Fitsum Sebsibe Teni ◽  
Ola Rolfson ◽  
Nancy Devlin ◽  
David Parkin ◽  
Emma Nauclér ◽  
...  
Keyword(s):  
General Population ◽  
Data Retrieval ◽  
Health State ◽  
Health States ◽  
National Quality ◽  
Patient Reported ◽  
Patient Groups ◽  
Value Sets ◽  
Eq Vas

BACKGROUND EQ-5D is one of the most commonly used questionnaires to measure health-related quality of life. It is included in many of the Swedish National Quality Registers (NQRs). EQ-5D health states are usually summarized using “values” obtained from members of the general public, a majority of whom are healthy. However, an alternative, which remains to be studied in detail, is the potential to use patients’ self-reported overall health on the visual analog scale (VAS) as a means of capturing experience-based perspective. OBJECTIVE The aim of this study is to assess EQ VAS as a valuation method with an experience-based perspective through comparison of its performance across and within patient groups, and with that of the general population in Sweden. METHODS Data on nearly 700,000 patients from 12 NQRs covering a variety of diseases/conditions and nearly 50,000 individuals from the general population will be analyzed. The EQ-5D-3L data from the 12 registers and EQ-5D-5L data from 2 registers will be used in the analyses. Longitudinal studies of patient-reported outcomes among different patient groups will be conducted in the period from baseline to 1-year follow-up. Descriptive statistics and analyses comparing EQ-5D dimensions and observed self-assessed EQ VAS values across and within patient groups will be performed. Comparisons of the change in health state and observed EQ VAS values at 1-year follow-up will also be undertaken. Regression models will be used to assess whether EQ-5D dimensions predict observed EQ VAS values to investigate patient value sets in each patient group. These will be compared across the patient groups and with the existing Swedish experience-based VAS and time trade-off value sets obtained from the general population. RESULTS Data retrieval started in May 2019 and data of patients in the 12 NQRs and from the survey conducted among the general population have been retrieved. Data analysis is ongoing on the retrieved data. CONCLUSIONS This research project will provide information on the differences across and within patient groups in terms of self-reported health status through EQ VAS and comparison with the general population. The findings of the study will contribute to the literature by exploring the potential of self-assessed EQ VAS values to develop value sets using an experience-based perspective. CLINICALTRIAL ClinicalTrials.gov NCT04359628; https://clinicaltrials.gov/ct2/show/NCT04359628. INTERNATIONAL REGISTERED REPORT DERR1-10.2196/27669

scholarly journals Reference Data and Known-Groups Validity of the EQ-5D-5L for Vietnam

2021 ◽  
Author(s):  
Mai Quynh Vu ◽  
Giang Bao Kim ◽  
Minh Van Hoang ◽  
Lars Lindholm ◽  
Sun Sun ◽  
...  
Keyword(s):  
General Population ◽  
Reference Data ◽  
Age Groups ◽  
Five Dimensions ◽  
Population Norms ◽  
Gender And Age ◽  
Vietnamese Population ◽  
The Mean ◽  
Eq Vas

Abstract PurposeThis study aims to provide EQ-5D-5L reference data of the general Vietnamese population and to test the EQ-5D-5L’ known-groups validity among people living with hypertension in Vietnam.MethodsThe EQ-5D-5L population norms were obtained via a representative sample from a general population of 1200 adults. Outcomes of the population norms were presented through five dimensions and five levels, EQ-VAS, and EQ-5D-5L indexes. Descriptive statistics of these outcomes were categorised by gender and age groups. Evidence of the known-groups validity was based on a sample of 577 non-hypertensive adults, 242 individuals with undiagnosed and 477 individuals with diagnosed hypertension. A hypothesis was formulated that people with worse health status would have lower EQ-VAS and EQ-5D-5L indexes. ResultsFor the EQ-5D-5L population norms, 54.4% of the respondents reported having full health. The mean EQ-VAS and EQ-5D-5L indexes were 81.10 and 0.94, respectively. The EQ-VAS and EQ-5D-5L indexes were higher among males, people at younger ages, those with more education, a paid job, and single. The mean EQ-VAS and EQ-5D-5L indexes of people in the diagnosed hypertension group were statistically significantly lower than they were in the other two groups. ConclusionThe EQ-5D-5L population norms were derived for the Vietnamese general population. The EQ-5D-5L can distinguish the quality-of-life differences among Vietnamese with hypertension.

scholarly journals US population norms for the EQ-5D-5L and comparison of norms from face-to-face and online samples

2020 ◽  
Author(s):  
Ruixuan Jiang ◽  
M. F. Bas Janssen ◽  
A. Simon Pickard
Keyword(s):  
General Population ◽  
Health State ◽  
Sample Mean ◽  
Face To Face ◽  
Population Norms ◽  
The Us ◽  
Patient Health ◽  
The Face ◽  
Anxiety Depression ◽  
Eq Vas

Abstract Purpose Normative scores (norms) allow for comparisons between population(s) of interest and the general population, which is useful for burden of disease studies and cost-effectiveness analysis. The primary aim of this study was to estimate US visual analogue scale (EQ VAS) and utility-based norms for the EQ-5D-5L using the face-to-face sample. The secondary aim was to compare norms estimated in the face-to-face and online populations. Methods This study estimated population norms from two general population surveys: (a) face-to-face and (b) online. In these surveys, respondents provided their health state using the EQ-5D-5L health classifier and the EQ VAS. Descriptive statistics, including mean, standard deviation (SD), 95% confidence interval, and median for the 5L utility and EQ VAS were estimated for each sample and across relevant respondent characteristics to serve as the basis for US EQ-5D-5L norms Results Face-to-face sample respondents (n = 1134) were representative of the US adult general population. In this sample, mean (SD) utility decreased with increasing age until age 45 or greater (age 45–54: 0.816 (0.249) age 55–64: 0.815 (0.243) age 65–74: 0.824 (0.217) age 75 + : 0.811 (0.218)). With increasing age, more problems were reported on all dimensions except anxiety/depression; a smaller proportion of respondents age 65 and older reported problems with anxiety/depression (23.8%) as compared to the youngest respondents (42.1%). Online (n = 2018) mean utility and EQ VAS values were consistently lower than the face-to-face sample. Conclusions The availability of US EQ-5D-5L norms facilitates interpretation and understanding of general population and patient health.

HSR19-107: Nivolumab for Newly Diagnosed Classical Hodgkin Lymphoma: Patient-Reported Outcomes From CheckMate 205 Cohort D

2019 ◽  
Vol 17 (3.5) ◽  
pp. HSR19-107
Author(s):  
Radhakrishnan Ramchandren ◽  
Stephen M. Ansell ◽  
Philippe Armand ◽  
Andreas Engert ◽  
Fiona Taylor ◽  
...  
Keyword(s):  
Hodgkin Lymphoma ◽  
Self Care ◽  
Newly Diagnosed ◽  
Classical Hodgkin Lymphoma ◽  
Meaningful Improvement ◽  
Patient Reported ◽  
Vas Scores ◽  
Care Activity ◽  
Eq Vas

Background: Patients (pts) with classical Hodgkin lymphoma (cHL) frequently experience reduced health-related quality of life (HRQoL) (Oerlemans et al, Ann Hematol 2011). Nivolumab, a fully human IgG4 anti-programmed death-1 (PD-1) immune checkpoint inhibitor monoclonal antibody, demonstrated efficacy and clinically meaningful improvement in pt-reported outcomes (PROs) in pts with relapsed/refractory cHL in cohorts A, B, and C of CheckMate 205 (NCT02181738) (Armand et al, J Clin Oncol 2018; Engert et al, ASH 2017). Nivolumab monotherapy followed by nivolumab + doxorubicin, vinblastine and dacarbazine (N-AVD) demonstrated an objective response rate of 84% in newly diagnosed cHL (cohort D of CheckMate 205; Ramchandren et al, EHA 2018). We present PROs in CheckMate 205 cohort D. Methods: Pts ≥18 years of age with untreated, advanced-stage cHL, with ECOG performance status (PS) of 0–1 received 4 doses of nivolumab monotherapy (240 mg IV Q2W) followed by N-AVD for 6 cycles (12 doses). Pts then entered the follow-up (FU) period. PROs were an exploratory endpoint, assessed using the EuroQol 5 Dimensions-3 level (EQ-5D-3L) and associated visual analog scale (EQ-VAS) in all treated pts who had both a baseline (monotherapy cycle 1) and post-baseline assessment. EQ-VAS ranges from 0–100, with higher scores indicating better HRQoL. In EQ-5D-3L, pts can report no, some, or extreme problems in each of 5 dimensions (mobility, self-care, activity, pain, and anxiety). Results: 51 pts were treated. At baseline, median age was 37 years, 63% were male, 59% had ECOG PS of 0. 49 pts (96%) completed baseline EQ-VAS. Mean EQ-VAS scores exceeded the mean baseline score at the end of monotherapy, after 2 combination cycles, at the end of therapy, and during follow-up (Table 1). The proportion of pts reporting some or extreme problems in EQ-5D-3L was numerically lower than or similar to baseline after monotherapy for all dimensions, but was numerically higher than baseline (dimensions of mobility and activity) after 2 combination cycles, and remained close to or numerically below baseline during follow-up (dimensions of self-care, activity, pain, and anxiety). Conclusions: Pt-reported HRQoL, as assessed by observed mean EQ-VAS scores, did not deteriorate from baseline during treatment with nivolumab followed by N-AVD. Proportions of pts reporting problems in individual EQ-5D-3L dimensions were generally similar to baseline during treatment and follow-up.

Factors influencing depression endpoints research (FINDER): Study design and population characteristics

2008 ◽  
Vol 23 (1) ◽  
pp. 57-65 ◽  
Author(s):  
Ana Garcia-Cebrian ◽  
Michael Bauer ◽  
Angel L. Montejo ◽  
Nicolas Dantchev ◽  
Koen Demyttenaere ◽  
...  
Keyword(s):  
Quality Of Life ◽  
General Population ◽  
Study Design ◽  
Short Form ◽  
Clinical Depression ◽  
Population Characteristics ◽  
Population Norms ◽  
Factors Influencing ◽  
Sf 36

AbstractFactors influencing outcomes of depression in clinical practice, especially health-related quality of life (HRQoL), are poorly understood. The Factors Influencing Depression Endpoints Research (FINDER) study is a European prospective, observational study designed to estimate the HRQoL of adults with a clinically diagnosed depressive episode at baseline, and 3 and 6 months after commencing antidepressant medication. We report here the study design and baseline patient characteristics.HRQoL was assessed by the 36-item Short-Form Health Survey (SF-36) and European Quality of Life-5 Dimensions (EQ-5D). Patient ratings on Hospital Anxiety and Depression Scale (HADS) and pain Visual Analogue Scale (VAS) were also obtained. Results (n = 3468) showed that SF-36 mental component summary (mean 22.2) was more than two SDs below general population norms (mean 50.0) and one SD below clinical depression norms (mean 34.8); the physical component summary (mean 46.1) was similar to general population (mean 50.0) and clinical depression norms (mean 45.0). Mean EQ-5D scores were also lower than general population norms. Mean HADS-Depression and -Anxiety subscores were 12.3 and 13.0, respectively. Fifty-six percent of patients reported an overall pain VAS score of at least 30 mm and 70% of these patients had no physical explanation for their pain.Further investigation into factors associated with HRQoL in depression after treatment initiation is warranted.

Prevalence and Correlates of Nonpsychotic Psychiatric Symptoms in the General Population

1982 ◽  
Vol 27 (4) ◽  
pp. 316-324 ◽  
Author(s):  
Carl D'Arcy
Keyword(s):  
General Population ◽  
General Health ◽  
Large Scale ◽  
Psychiatric Symptoms ◽  
Social Systems ◽  
General Health Questionnaire ◽  
Age Groups ◽  
Older Age ◽  
Symptom Reporting ◽  
General Decline

This paper reports on the results of a large scale mail questionnaire survey of the prevalence, as well as some social/psychological correlates, of nonpsychotic psychiatric symptoms in the general population of the Province of Saskatchewan. The level of nonpsychotic psychiatric symptoms was measured using the 30-item General Health Questionnaire (GHQ) developed by Goldberg. The respondent group (2000+, 53% of the available sample) was reasonably representative of the provincial population and forms a good basis for generalization. Data analysis shows that women report a higher level of symptoms than men. There were also significant age variations:for women there was a general decline in mean scores from younger to older age categories with the possible exception of the oldest age group, over 70, in which we see a slight increase; for men, there was a pronounced U-shaped distribution with both younger and older age groups exhibiting high levels of symptomatology. In addition to age and sex, general health, relationships with spouse and others, and a sense of control over one's life experiences were found to be correlated with symptom reporting, underscoring the negative effects of ill health and the inequities in social systems as well as the positive value of good interpersonal relationships. Saskatchewan symptom reporting levels were found to be similar to those reported in Australian and British population samples. These other studies also showed higher levels of symptom reporting infernales than in males. The GHQ data were also factor analyzed to reveal sets or clusters of symptoms. The analysis showed that “anxiety” and “depression” were the major dimensions of the GHQ lending credence to the suggestion that psychiatric screening scales tend to measure “de-morale-ization,” that is, anxiety, sadness, helplessness/hopelessness and a lack of self-esteem.

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