Reference Data and Known-Groups Validity of the EQ-5D-5L for Vietnam

Abstract PurposeThis study aims to provide EQ-5D-5L reference data of the general Vietnamese population and to test the EQ-5D-5L’ known-groups validity among people living with hypertension in Vietnam.MethodsThe EQ-5D-5L population norms were obtained via a representative sample from a general population of 1200 adults. Outcomes of the population norms were presented through five dimensions and five levels, EQ-VAS, and EQ-5D-5L indexes. Descriptive statistics of these outcomes were categorised by gender and age groups. Evidence of the known-groups validity was based on a sample of 577 non-hypertensive adults, 242 individuals with undiagnosed and 477 individuals with diagnosed hypertension. A hypothesis was formulated that people with worse health status would have lower EQ-VAS and EQ-5D-5L indexes. ResultsFor the EQ-5D-5L population norms, 54.4% of the respondents reported having full health. The mean EQ-VAS and EQ-5D-5L indexes were 81.10 and 0.94, respectively. The EQ-VAS and EQ-5D-5L indexes were higher among males, people at younger ages, those with more education, a paid job, and single. The mean EQ-VAS and EQ-5D-5L indexes of people in the diagnosed hypertension group were statistically significantly lower than they were in the other two groups. ConclusionThe EQ-5D-5L population norms were derived for the Vietnamese general population. The EQ-5D-5L can distinguish the quality-of-life differences among Vietnamese with hypertension.

Download Full-text

Reference data among general population and known-groups validity among hypertensive population of the EQ-5D-5L in Vietnam

Quality of Life Research ◽

10.1007/s11136-021-02959-2 ◽

2021 ◽

Author(s):

Vu Quynh Mai ◽

Kim Bao Giang ◽

Hoang Van Minh ◽

Lars Lindholm ◽

Sun Sun ◽

...

Keyword(s):

General Population ◽

Group Testing ◽

Age Groups ◽

Obese People ◽

Five Dimensions ◽

Population Norms ◽

Hypertensive Group ◽

The Mean ◽

Body Mass Indexes ◽

Eq Vas

Abstract Purpose This study aims to provide EQ-5D-5L population norms among the general population in Vietnam and to test EQ-5D-5L’ construction validity among people living with hypertension there. Methods Descriptive statistics of the five dimensions and five levels, EQ-VAS and EQ-5D-5L indexes were categorised into gender and age groups for the EQ-5D-5L population norms. Known-groups testing was set for lower EQ-5D-5L outcomes among people who were aware of their hypertensive status, females, people with more comorbidities, less education, older ages, and higher body mass indexes. Level of confident interval was 95%. Results The mean EQ-VAS and EQ-5D-5L indexes were 81.10 (SD: 13.35) and 0.94 (SD: 0.09) among the general population. The EQ-5D-5L outcomes were better among younger people, males, people with more education, employees, and single people. Respondents reported fewer problems with self-care and usual activities and tend to have problems at higher levels across older ages. The known-group testing showed statistically significant results. The mean EQ-VAS and EQ-5D-5L indexes of people in the diagnosed hypertensive group (71.48 and 0.94, respectively) were statistically significantly smaller than they were in the non-hypertensive and undiagnosed hypertensive group (76.65 and 0.97; 76.95 and 0.96 accordingly). Statistically significant associations of lower EQ-5D-5L indexes and EQ-VAS were found among people diagnosed for hypertension, people suffering from an incremental comorbidity, and obese people. Conclusion This study has provided EQ-5D-5L population norms for the general population and evidence for known-groups validity of the EQ-5D-5L instrument among hypertensive people in Vietnam.

Download Full-text

The Swedish RAND-36: psychometric characteristics and reference data from the Mid-Swed Health Survey

Journal of Patient-Reported Outcomes ◽

10.1186/s41687-021-00331-z ◽

2021 ◽

Vol 5 (1) ◽

Author(s):

Emma Ohlsson-Nevo ◽

Ayako Hiyoshi ◽

Paulina Norén ◽

Margareta Möller ◽

Jan Karlsson

Keyword(s):

Quality Of Life ◽

Mental Health ◽

General Population ◽

Physical Health ◽

Data Quality ◽

Reference Data ◽

Age Groups ◽

Older Age ◽

Role Functioning

Abstract Background This study aims to evaluate data quality, scaling properties, and reliability of the Swedish RAND-36 in a general population sample and to present reference data for the Swedish population. Methods Testing of data quality, scaling assumptions and reliability followed methods recommended for the International Quality of Life Assessment Project, previously used for psychometric testing of SF-36 and RAND-36. Data were collected via regular mail for a random stratified sample of the general population in a Swedish county. Weighted means for RAND-36 scores were used and differences by sex, age, education, and occupational groups were tested. Results The response rate was 42%, and the sample comprised 3432 persons (45% men, 55% women) with a median age of 56.9 years. The internal consistency reliability was satisfactory, with Cronbach’s alphas > 0.80 for all eight scales. The percentage of missing items was low, ranging between 1.3% and 3.2%. No floor effects (≥15%) were noted, while ceiling effects were observed for physical functioning, role-functioning/physical, pain, role-functioning/emotional, and social functioning. Item–scale correlations were satisfactory (r ≥ 0.40). Correlations among the physical health scales were strong (range 0.58–0.68) as were the correlations among the mental health scales (range 0.58–0.73). Men reported significantly better health-related quality of life (HRQoL) on all scales, although the gender differences were small. Comparisons among age groups showed approximately equal scores among those 20–29, 30–39, and 40–49 years, while significant decreases in physical health were observed in the older age groups. Substantially worse physical health scores were observed in the oldest age group (80+). Significant differences among age groups were noted also for the mental health scales; however, better energy/fatigue and emotional well-being scores were seen in the older age groups, except for the oldest (80+). Those with university education reported significantly better scores on all scales compared to those with mandatory education. Conclusions The study suggests that the Swedish version of RAND-36 is an acceptable and reliable instrument for measuring HRQoL in the general population. The study provides reference data that can be used for norm-based comparisons.

Download Full-text

Norwegian Population Norms for the EQ-5D-5L: Results From a General Population Survey

10.21203/rs.3.rs-303129/v1 ◽

2021 ◽

Cited By ~ 1

Author(s):

Andrew Malcolm Garratt ◽

Tonya Moen Hansen ◽

Liv Ariane Augestad ◽

Kim Rand ◽

Knut Stavem

Keyword(s):

General Population ◽

Age Groups ◽

Education Level ◽

Services Research ◽

Population Norms ◽

General Decline ◽

National Quality ◽

Patient Reported ◽

Vas Scores ◽

Eq Vas

Abstract Purpose: To provide the first Norwegian EQ-5D-5L and EQ VAS population norms for the adult general population. Methods: Postal survey of a random sample of 12,790 Norwegians identified through the National Registry of the Norwegian Tax Administration. Norms are shown for the five EQ-5D-5L dimensions, EQ-5D index and EQ VAS scores for seven age categories, males, females and education level. Results: There were 3,200 (25.9%) respondents to 12,263 correctly addressed questionnaires. The EQ-5D-5L dimensions, EQ VAS and background questions were completed by 3,120 (24.6%) respondents. The mean age (SD) was 50.9 (21.7); range 18 to 97 years. The youngest age group of 18-29 years and oldest of 80 years and over had the highest (n=691) and lowest (n=239) number of respondents respectively. Compared to the general population, the respondents comprised a greater number of females, younger and older ages, and had a higher education level. 32% of respondents reported no health problems on the EQ-5D-5L. From the youngest to oldest age groups, there was a general decline in health as assessed by the EQ-5D-5L. The exception was for anxiety/depression, where the youngest age groups had the poorest health. Apart from self-care, women reported poorer health than men, as assessed by the EQ-5D-5L; EQ VAS scores were similar for men and women. Higher levels of health (EQ-5D index, EQ VAS scores) were found with increasing levels of education. Conclusion: The population norms will improve interpretation of EQ-5D-5L and EQ VAS scores in Norwegian applications including clinical practice, clinical and health services research, and national quality registers where EQ-5D-5L is the most widely used patient-reported instrument.

Download Full-text

Norwegian population norms for the EQ-5D-5L: results from a general population survey

Quality of Life Research ◽

10.1007/s11136-021-02938-7 ◽

2021 ◽

Author(s):

Andrew Malcolm Garratt ◽

Tonya Moen Hansen ◽

Liv Ariane Augestad ◽

Kim Rand ◽

Knut Stavem

Keyword(s):

General Population ◽

Age Groups ◽

Education Level ◽

Population Characteristics ◽

Population Norms ◽

General Decline ◽

National Quality ◽

Patient Reported ◽

Vas Scores ◽

Eq Vas

Abstract Purpose To provide the first Norwegian EQ-5D-5L and EQ VAS population norms for the adult general population. Methods Postal survey of a random sample of 12,790 Norwegians identified through the National Registry of the Norwegian Tax Administration. Norms, weighted for Norwegian general population characteristics, are shown for the five EQ-5D-5L dimensions, EQ-5D index, and EQ VAS scores for seven age categories, females, males, and education level. Results There were 3200 (25.9%) respondents to 12,263 correctly addressed questionnaires. The EQ-5D-5L dimensions, EQ VAS, and background questions were completed by 3120 (24.6%) respondents. The mean age (SD) was 50.9 (21.7) and range was 18–97 years. The youngest age group of 18–29 years and oldest of 80 years and over had the highest (n = 691) and lowest (n = 239) number of respondents, respectively. Compared to the general population, the respondents comprised a greater number of females, younger and older ages, and had a higher education level. 32% of respondents reported no health problems on the EQ-5D-5L. From the youngest to oldest age groups, there was a general decline in health as assessed by the EQ-5D-5L. The exception was for anxiety/depression, where the youngest age groups had the poorest health. Apart from self-care, women reported poorer health than men, as assessed by the EQ-5D-5L; EQ VAS scores were similar for men and women. Higher levels of health (EQ-5D index, EQ VAS scores) were found with increasing levels of education. Conclusion The population norms will improve interpretation of EQ-5D-5L and EQ VAS scores in Norwegian applications including clinical practice, clinical and health services research, and national quality registers where EQ-5D-5L is the most widely used patient-reported instrument.

Download Full-text

EQ-5D-5L-based quality of life normative data for patients with self-reported diabetes in Poland

PLoS ONE ◽

10.1371/journal.pone.0257998 ◽

2021 ◽

Vol 16 (9) ◽

pp. e0257998

Author(s):

Agnieszka Jankowska ◽

Dominik Golicki

Keyword(s):

Quality Of Life ◽

General Population ◽

Normative Data ◽

Clinical Care ◽

Population Sample ◽

Age Groups ◽

Patients With Diabetes ◽

Related Quality ◽

Eq Vas

Introduction The new, five-level EQ-5D generic questionnaire (EQ-5D-5L) has never been used among diabetes patients in Poland. Objectives To develop health-related quality of life (HRQoL) norms for patients with self-reported diabetes, based on a large representative sample of the general Polish population, using the EQ-5D-5L. Materials and methods Members of the general public, selected via multistage stratified sampling, filled in the EQ-5D-5L questionnaire and answered a question about the presence of diabetes. We estimated three types of EQ-5D-5L outcomes: limitations within domains, EQ VAS and EQ-5D-5L index. Multiple linear regression was used to examine the relationship between sociodemographic characteristics and HRQoL, both in patients with diabetes and the general population sample. Results Among 2,973 respondents having complete EQ-5D-5L data, 255 subjects (8.6%) self-reported diabetes. Treatment with insulin, other drugs, combination therapy or lack of drug treatment was declared by 22.0%, 48.6%, 5.1% and 24.3% of patients, respectively. Respondents with diabetes had a lower EQ VAS score (18.5 points difference on a 100-points scale) and a lower EQ-5D-5L index score (0.135 difference; scale range: 1.59). The multivariate analysis showed that the factors independently improving the HRQoL in the general population were secondary or higher education, and factors reducing HRQoL were female sex, belonging to an older age group, being treated because of diabetes with insulin, other drugs or combination treatment. Respondents diagnosed with diabetes but not treated with drugs showed a decrease in EQ VAS scores, but not in the EQ-5D-5L index. Conclusions Diabetes leads to HRQoL deterioration in all age groups when compared to matched general population respondents without diabetes. The most significant HRQoL reduction experience older patients with a basic level of education. Obtained EQ-5D-5L normative data may be used in the clinical care of patients with diabetes and health technology assessment of new anti-diabetic drugs.

Download Full-text

ASSESSMENT OF THE HEALTH-RELATED QUALITY OF LIFE IN OUTPATIENTS WITH DIABETES MELLITUS AT HUE UNIVERSITY OF MEDICINE AND PHARMACY HOSPITAL

Journal of Medicine and Pharmacy ◽

10.34071/jmp.2020.6.5 ◽

2019 ◽

pp. 35-42

Author(s):

Tri Vo Duc ◽

Ngoc Nguyen Phuoc Bich

Keyword(s):

Quality Of Life ◽

Diabetes Mellitus ◽

Health Related Quality ◽

Vas Score ◽

Related Quality ◽

Health Related ◽

The Mean ◽

Lower Hrqol ◽

Eq Vas

Background: The prevalence of diabetes mellitus (DM) has been increasing significantly in the world as well as in Viet Nam. DM is a serious and complex chronic disease that affects the physical health of the patients and lower health-related quality of life (HRQoL). Objectives: (1) To analyze the HRQoL in DM outpatients at Hue University of Medicine and Pharmacy Hospital. (2) To evaluate the associated factorsin outpatients with DM. Materials and method: A cross-sectional descriptive study was conducted on 253 outpatients at Hue University of Medicine and Pharmacy Hospital. EuroQoL-5 dimension-5 level (EQ-5D-5L) scale was used for the assessment of HRQoL. Results: The median of the EQ-5D index was 0.85(interquartile range (IQR) = 0.28). The mean of EQ-VAS score was 64.07 (SD=16.99). Aging was associated with lower HRQoL. Unemployed participants had the lowest HRQoL index compared to workers. Higher educational levels led to higher HRQoL. Patients withDM duration of over 10 years had lower HRQoL index than the other groups. Conclusion: The median of the EQ-5D index was 0.85 (IQR = 0.28). The mean of EQ-VAS score was 64.07 (SD=16.99). The HRQoL in diabetic patients was associated with age, occupation, level of education and DM duration. Key words: EQ-5D-5L, quality of life, diabetes mellitus.

Download Full-text

Subjective Well-Being in Non-Obese Individuals in View of Abdominal Fat Distribution and Muscle Mass Index: A General Population Study.

10.21203/rs.3.rs-482840/v1 ◽

2021 ◽

Author(s):

Małgorzata Chlabicz ◽

Marlena Paniczko ◽

Jacek Jamiołkowski ◽

Paweł Sowa ◽

Małgorzata Szpakowicz ◽

...

Keyword(s):

Body Composition ◽

General Population ◽

Muscle Mass ◽

Negative Impact ◽

Fat Distribution ◽

Well Being ◽

Abdominal Fat ◽

Satisfaction With Life Scale ◽

The Mean ◽

Eq Vas

Abstract Background While obesity has been correlated with welfare in the general population, there is not much data on the influence of body composition on welfare among the non-obese adult individuals. Methods A longitudinal, population-based study was conducted in 2017–2020. Body composition was assessed using Dual Energy X-ray Absorptiometry. Welfare was rated with Satisfaction with Life Scale (SWLS), Euro Quality of Life Visual Analogue Scale (EQ-VAS) and Beck Depression Inventory (BDI). Results A total of 726 non-obese individuals from general population were analyzed. The mean age was 46.8 ± 15.4 years and 42.1% of participants were male. The mean value for SWLS was 23.09 ± 5.43, for EQ-VAS was 78.0 ± 14.5, and for BDI was 6.7 ± 6.6. On SWLS the waist-hip ratio had a negative impact even after adjustment for age, gender and concomitant diseases. EQ-VAS was inversely associated with android fat distribution and directly associated with muscle mass. BDI value was inversely associated with lower muscle mass, especially of the lower limbs. The well-being of women was mainly associated with the distribution of adipose tissue and less with the distribution of muscle tissue - abdominal fat distribution has a particularly negative impact on well-being among women. In contrast, men's well-being depends more on muscle mass and to a lesser extent on the distribution of fat tissue - a positive significant effect has lean mass and a circumference of thigh below gluteal fold. Conclusions Body composition is significantly associated with welfare in non-obese population. Android type fat distribution may have a negative impact while muscle mass positive.

Download Full-text

Abstract 204: Cross-sectional Survey of Quality of Life and Workload Among Japanese Physicians Working in Stroke Care: The Nationwide Survey of Acute Stroke Care Capacity for Proper Designation of Comprehensive Stroke Center in Japan (J-ASPECT) Study

Circulation Cardiovascular Quality and Outcomes ◽

10.1161/circoutcomes.8.suppl_2.204 ◽

2015 ◽

Vol 8 (suppl_2) ◽

Author(s):

Fumiaki Nakamura ◽

Kunihiro Nishimura ◽

Misa Takegami ◽

Yoshihiro Miyamoto ◽

Koji Iihara

Keyword(s):

Quality Of Life ◽

General Population ◽

Short Form ◽

Stroke Care ◽

Cross Sectional Survey ◽

Cross Sectional ◽

Neurosurgical Society ◽

The Mean ◽

Population Norm

Objective: Approximately 40% of stroke physicians in Japan are in a state of burnout. The quality of life (QOL) of physicians working in stroke care is unclear. We aimed to compare health-related QOL (HRQOL) between physicians working in stroke care and the general population, and to evaluate personal and professional characteristics associated with HRQOL of physicians working in stroke care. Design: Cross-sectional survey. Setting and Participants: All board-certified members of the Japanese Neurosurgical Society and the Societas Neurologica Japonica working in Japan. Main outcome measure: Scores of HRQOL (physical and mental) as assessed by the Short-Form 8 (SF-8). Statistical analysis: We compared scores of physician’s HRQOL with standard values of the general population. Factors associated with HRQOL were identified by multivariable regression analysis with stepwise variable selection. Results: Of 11,211 stroke physicians who received the survey, 2279 (20.3%) completed the surveys. The mean physical QOL score was 49.4 points (95% CI: 49.1 to 49.7), which was similar to the population norm. However, the mean mental QOL score was below the population norm (46.1 points [95% CI: 45.7 to 46.4]), and 20.8% (475/2279) of stroke physicians had a score lower than one standard deviation below the population norm. The physical QOL score was lower in women than in men (coefficient = –1.66 [95% CI: –2.82 to –0.50]). An increase in nights on call per week was associated with a lower physical QOL (each additional 1 time per week = –0.39 [–0.53 to –0.25]), and an increase in mean sleep time was associated with a higher physical QOL score (each additional 1 hour = 0.87 [0.55 to 1.20]). Physicians who worked more than 40 hours per week had a lower mean mental QOL score than those who worked less than 40 hours per week (each additional 10 hour = –0.40 [–0.57 to –0.24]). A higher salary was associated with a higher mental QOL score (lower than $100 000 = reference; $100 000-149 000 = 0.08 [–1.10 to 1.27]; $150 000-199 000 = 0.68 [–0.61 to 1.97]; $200 000 or more = 1.90 [0.46 to 3.34]), and an increase of 1 day off per week was associated with an increase in mental QOL score (each additional 1 day = 0.88 [0.24 to 1.52]). Limitation: This study was based on a cross-sectional design and was thus unable to determine the causal effects of factors. Conclusion: Mental QOL scores of stroke physicians are significantly lower than those of the population norm. Work hours, salary, and numbers of days off are associated with the mental QOL score.

Download Full-text

US population norms for the EQ-5D-5L and comparison of norms from face-to-face and online samples

Quality of Life Research ◽

10.1007/s11136-020-02650-y ◽

2020 ◽

Author(s):

Ruixuan Jiang ◽

M. F. Bas Janssen ◽

A. Simon Pickard

Keyword(s):

General Population ◽

Health State ◽

Sample Mean ◽

Face To Face ◽

Population Norms ◽

The Us ◽

Patient Health ◽

The Face ◽

Anxiety Depression ◽

Eq Vas

Abstract Purpose Normative scores (norms) allow for comparisons between population(s) of interest and the general population, which is useful for burden of disease studies and cost-effectiveness analysis. The primary aim of this study was to estimate US visual analogue scale (EQ VAS) and utility-based norms for the EQ-5D-5L using the face-to-face sample. The secondary aim was to compare norms estimated in the face-to-face and online populations. Methods This study estimated population norms from two general population surveys: (a) face-to-face and (b) online. In these surveys, respondents provided their health state using the EQ-5D-5L health classifier and the EQ VAS. Descriptive statistics, including mean, standard deviation (SD), 95% confidence interval, and median for the 5L utility and EQ VAS were estimated for each sample and across relevant respondent characteristics to serve as the basis for US EQ-5D-5L norms Results Face-to-face sample respondents (n = 1134) were representative of the US adult general population. In this sample, mean (SD) utility decreased with increasing age until age 45 or greater (age 45–54: 0.816 (0.249) age 55–64: 0.815 (0.243) age 65–74: 0.824 (0.217) age 75 + : 0.811 (0.218)). With increasing age, more problems were reported on all dimensions except anxiety/depression; a smaller proportion of respondents age 65 and older reported problems with anxiety/depression (23.8%) as compared to the youngest respondents (42.1%). Online (n = 2018) mean utility and EQ VAS values were consistently lower than the face-to-face sample. Conclusions The availability of US EQ-5D-5L norms facilitates interpretation and understanding of general population and patient health.

Download Full-text

Quality of Life in Patients with Systemic Sclerosis Compared to the General Population and Patients with Other Chronic Conditions

The Journal of Rheumatology ◽

10.3899/jrheum.080281 ◽

2009 ◽

Vol 36 (4) ◽

pp. 768-772 ◽

Cited By ~ 42

Author(s):

MARIE HUDSON ◽

BRETT D. THOMBS ◽

RUSSELL STEELE ◽

PANTELIS PANOPALIS ◽

EVAN NEWTON ◽

...

Keyword(s):

Quality Of Life ◽

Systemic Sclerosis ◽

General Population ◽

Chronic Diseases ◽

Chronic Conditions ◽

Short Form ◽

Mental Component Summary Score ◽

Population Norms ◽

Sf 36

Objective.Systemic sclerosis (SSc) affects multiple physical, psychological, and social domains and is associated with impaired health-related quality of life (HRQOL).We compared the HRQOL of SSc patients with individuals in the general population and patients with other common chronic diseases.Methods.HRQOL of SSc patients in the Canadian Scleroderma Research Group registry was measured using version 2 of the Medical Outcomes Trust Short Form-36 (SF-36). Results were compared to US general population norms and scores reported for patients with other common chronic diseases, namely heart disease, lung disease, hypertension, diabetes, and depression.Results.SF-36 scores were available for 504 SSc patients (86% women, mean age 56 yrs, mean disease duration since onset of first non-Raynaud’s manifestation of SSc 11 yrs). The greatest impairment in SF-36 subscale scores appeared to be in the physical functioning, general health, and role physical domains. SF-36 subscale and summary scores in SSc were significantly worse compared to US general population norms for women of similar ages, except for mental health and mental component summary score, which were not significantly different, and were generally comparable to or worse than the scores of patients with other common chronic conditions.Conclusion.HRQOL of patients with SSc is significantly impaired compared to that of the general population and is comparable to or worse than that of patients with other common chronic conditions.

Download Full-text