Immune responses elicited in mice with recombinant Lactococcus lactis expressing F4 fimbrial adhesin FaeG by oral immunization

2010 ◽  
Vol 34 (6) ◽  
pp. 491-502 ◽  
Author(s):  
Shujie Liu ◽  
Yongming Li ◽  
Ziwei Xu ◽  
Yicheng Wang
Keyword(s):  
Immune Responses ◽  
Lactococcus Lactis ◽  
Oral Immunization ◽  
Recombinant Lactococcus Lactis ◽  
Fimbrial Adhesin

Immunogenicity and protective efficacy of orally administered recombinant Lactococcus lactis expressing surface-bound HIV Env

Blood ◽  
2003 ◽  
Vol 102 (1) ◽  
pp. 223-228 ◽  
Author(s):  
Ke-Qin Xin ◽  
Yuka Hoshino ◽  
Yoshihiko Toda ◽  
Shizunobu Igimi ◽  
Yoshitsugu Kojima ◽  
...  
Keyword(s):  
Immune Responses ◽  
Lactococcus Lactis ◽  
Potential Role ◽  
Protective Efficacy ◽  
Oral Immunization ◽  
Vaccine Strategy ◽  
Regional Lymph Nodes ◽  
Viral Loads ◽  
Recombinant Lactococcus Lactis ◽  
Further Development

Abstract This study investigates whether genetically modified orally administered Lactococcus lactis (L lactis) could be used as an HIV vaccine. L lactis is immunogenic and extremely safe when delivered orally. We created a recombinant L lactis vector expressing the envelope protein of HIV on its cell surface. Oral immunization with this vector induced high levels of HIV-specific serum IgG and fecal IgA antibodies. Cell-mediated immune responses also were generated in both the regional lymph nodes and the spleen. Dendritic cells are readily infected by L lactis and appear to play a potential role in mediating the development of these immune responses. The protective efficacy of this vaccine strategy was demonstrated by challenging mice intraperitoneally with an HIV Env–expressing vaccinia virus. Their viral loads were 350-fold lower than those of control mice. These findings support the further development of L lactis–based HIV vaccines. (Blood. 2003; 102:223-228)

scholarly journals Oral immunization of a non-recombinant Lactococcus lactis surface displaying influenza hemagglutinin 1 (HA1) induces mucosal immunity in mice

PLoS ONE ◽  
2017 ◽  
Vol 12 (11) ◽  
pp. e0187718 ◽  
Author(s):  
Pui-Fong Jee ◽  
Vunjia Tiong ◽  
Meng-Hooi Shu ◽  
Jing-Jing Khoo ◽  
Won Fen Wong ◽  
...  
Keyword(s):  
Lactococcus Lactis ◽  
Mucosal Immunity ◽  
Oral Immunization ◽  
Influenza Hemagglutinin ◽  
Recombinant Lactococcus Lactis

scholarly journals Subcutaneous or Oral Immunization of Mice with Lactococcus lactis Expressing F4 Fimbrial Adhesin FaeG

2013 ◽  
Vol 75 (6) ◽  
pp. 779-784 ◽  
Author(s):  
Shujie LIU ◽  
Yongming LI ◽  
Ziwei XU ◽  
Yicheng WANG
Keyword(s):  
Lactococcus Lactis ◽  
Oral Immunization ◽  
Fimbrial Adhesin
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