Waist-to-height ratio distinguish obstructive sleep apnea from primary snoring in obese children

The purpose of our study is to assess the impact of cardiac arrhythmias, heart rhythm variability in patients with ischemic heart disease, obstructive sleep apnea and primary snoring. 65 patients at an age of 40–68 years with ischemic heart disease, obstructive sleep apnea and primary snoring were researched.Obstructive sleep apnea and primary snoring lead to an increase in the sympathetic and parasympathetic activity of the autonomic nervous system on the sinus node in patients with ischemic heart disease, obstructive sleep apnea and primary snoring.

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H3K23/H3K36 hypoacetylation and HDAC1 up-regulation are associated with adverse consequences in obstructive sleep apnea patients

Scientific Reports ◽

10.1038/s41598-021-00052-9 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Yung-Che Chen ◽

Po-Yuan Hsu ◽

Chien-Hung Chin ◽

Chang-Chun Hsiao ◽

Chia-Wei Liou ◽

...

Keyword(s):

Obstructive Sleep Apnea ◽

Sleep Apnea ◽

Mononuclear Cells ◽

Gene Promoter ◽

Peripheral Blood Mononuclear ◽

Protein Levels ◽

Reactive Protein ◽

Primary Snoring ◽

Obstructive Sleep

AbstractThe aim of this study is to determine the roles of global histone acetylation (Ac)/methylation (me), their modifying enzymes, and gene-specific histone enrichment in obstructive sleep apnea (OSA). Global histone modifications, and their modifying enzyme expressions were assessed in peripheral blood mononuclear cells from 56 patients with OSA and 16 matched subjects with primary snoring (PS). HIF-1α gene promoter-specific H3K36Ac enrichment was assessed in another cohort (28 OSA, 8 PS). Both global histone H3K23Ac and H3K36Ac expressions were decreased in OSA patients versus PS subjects. H3K23Ac expressions were further decreased in OSA patients with prevalent hypertension. HDAC1 expressions were higher in OSA patients, especially in those with excessive daytime sleepiness, and reduced after more than 6 months of continuous positive airway pressure treatment. H3K79me3 expression was increased in those with high C-reactive protein levels. Decreased KDM6B protein expressions were noted in those with a high hypoxic load, and associated with a higher risk for incident cardiovascular events or hypertension. HIF-1α gene promoter-specific H3K36Ac enrichment was decreased in OSA patients versus PS subjects. In vitro intermittent hypoxia with re-oxygenation stimuli resulted in HDAC1 over-expression and HIF-1α gene promoter-specific H3K36Ac under-expression, while HDAC1 inhibitor, SAHA, reversed oxidative stress through inhibiting NOX1. In conclusions, H3K23/H3K36 hypoacetylation is associated with the development of hypertension and disease severity in sleep-disordered breathing patients, probably through up-regulation of HDAC1, while H3K79 hypermethylation is associated with higher risk of cardiovascular diseases, probably through down-regulation of KDM6B.

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C-Reactive Protein Levels Among Obese Children With Obstructive Sleep Apnea

10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a3708 ◽

2010 ◽

Author(s):

Anuj Bhardwaj ◽

Katharina Graw-Panzer ◽

Haesoon Lee

Keyword(s):

Obstructive Sleep Apnea ◽

Sleep Apnea ◽

Obese Children ◽

C Reactive Protein ◽

Protein Levels ◽

Reactive Protein ◽

Obstructive Sleep

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0572 Using Anthropometric Measures to Screen for Obstructive Sleep Apnea in the Sleep Heart Health Study Cohort

SLEEP ◽

10.1093/sleep/zsaa056.569 ◽

2020 ◽

Vol 43 (Supplement_1) ◽

pp. A219-A219

Author(s):

K D Vana ◽

G E Silva ◽

J D Carreon ◽

S F Quan

Keyword(s):

Obstructive Sleep Apnea ◽

Sleep Apnea ◽

Screening Tool ◽

Health Study ◽

Heart Health ◽

Height Ratio ◽

Cut Point ◽

Proxy Variables ◽

Obstructive Sleep ◽

Significant Difference

Abstract Introduction Individuals at high risk for obstructive sleep apnea (OSA) may not access sleep clinics for reasons including immobility, transportation difficulties, or living in rural areas. An easy-to-administer OSA screening tool for different body types, independent of witnessed apneas or body mass index (BMI), is lacking to identify this group quickly. We compared the sensitivities (SNs), specificities (SPs), and receiving operator curves (ROCs) of the neck circumference/height ratio (NHR) and waist circumference/height ratio (WHR) in predicting moderate and severe OSA (apnea-hypopnea index [AHI] ≥15/hr) with the SN, SP, and ROC of the derived Stop-Bang Questionnaire (dSBQ), which was created from proxy variables from the Sleep Heart Health Study (SHHS). Methods Data from the SHHS baseline evaluation were used and included participants (N=5431) who completed polysomnograms and had neck and waist circumferences, height measurements, and the SHHS proxy variables. This data then was divided randomly into 1/3 for derivation and 2/3 for validation analyses. Results No statistical differences were seen for gender, age, or ethnicity between the derivation and validation samples. In the validation sample (n=3621), the NHR cut-point of 0.21 resulted in a SN of 91% and a SP of 26% for AHI ≥15/hr. The WHR cut-point of 0.51 resulted in a SN of 91% and a SP of 21% for AHI ≥15/hr. Comparing the validation NHR and the dSBQ ROC curves showed no significant difference (AUCs=0.69 and 0.70, respectively; p=0.22). However, the ROC curve for WHR was significantly lower than for the dSBQ (AUCs=0.63 and 0.70, respectively; p<0.0001). Comparing the derivation and validation ROCs showed no significant differences between NHR ROCs, p=0.81, or between WHR ROCs, p=0.67. Conclusion The NHR is a viable screening tool, independent of witnessed apneas and BMI, that can be used for different body types and is statistically comparable to the dSBQ. Support This work was supported by U01HL53938 and U01HL53938-07S (University of Arizona).

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