scholarly journals Association between ambient air pollution and multiple sclerosis: a systemic review and meta-analysis

Author(s):  
Chao Tang ◽  
Qing-Ru Li ◽  
Yan-Mei Mao ◽  
Yuan-Rui Xia ◽  
Heng-Sheng Guo ◽  
...  
2021 ◽  
Author(s):  
Chao Tang ◽  
Qing-Ru Li ◽  
Yan-Mei Mao ◽  
Yuan-Rui Xia ◽  
Heng-Sheng Guo ◽  
...  

Abstract The effects of air pollutants on autoimmune diseases are gaining increasing attention. At present, no studies have conducted systemic review and meta-analysis on ambient air pollution and multiple sclerosis (MS). In this paper, literature was collected in order to explore whether there was a connection between air pollutants and MS or not. Through electronic literature search, literature related to our research topic was collected in Cochrane Library, Embase and Pubmed till August 18, 2020 according to certain criteria. Pooled risk estimate and 95% confidence intervals (95%CI) were calculated by random-effect model analysis. After removing copies, browsing titles and abstracts and reading full text, 6 studies were finally included. The results showed that only particulate matter (PM) with aerodynamic diameter ≤10 (PM10) was related to MS (pooled HR=1.058, 95% CI=1.050-1.066), and no correlation was found between other pollutants and MS. There was no publication bias, and the heterogeneity analysis results were stable. PM is correlated with the disease MS, while other pollution is not connected with MS. More literature results need to be included to meta-analysis results for further study.


2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Mohammad Amin Farahmandfard ◽  
Ahmad Naghibzadeh-Tahami ◽  
Narges Khanjani

Abstract Objectives Some studies have shown that environmental risk factors, including air pollution, might be related to the incidence or recurrence of multiple sclerosis (MS). This systematic review was conducted to investigate the relation between air pollution and MS. Methods A systematic search was conducted in PubMed, Scopus, Science Direct, Embase, and Web of Science; until January 2020 with no restrictions. The search strategy was conducted with air pollution key words such as CO, PM2.5, PM10, SO2, and NO2, for exposure and the key word “Multiple sclerosis” as the outcome. Results Eventually, after applying the inclusion and exclusion criteria, 17 articles were included. The methodologies and outcomes reported were heterogeneous and different metrics had been used in the results; therefore conducting a meta-analysis was not possible. Eight studies had analyzed the relation between particulate matter (PM) and the prevalence or relapse of MS and had observed a significant relation. NO2 and NOx were associated with recurrence or prevalence of MS in three studies. But, in three cohort studies, no association was observed between air pollution and recurrence or occurrence of MS. Conclusions The results of this systematic review show that outdoor air pollution, especially PM and nitrogen oxides might be related to the prevalence or relapse of MS.


2018 ◽  
Vol 235 ◽  
pp. 576-588 ◽  
Author(s):  
Bo-Yi Yang ◽  
Zhengmin Qian ◽  
Steven W. Howard ◽  
Michael G. Vaughn ◽  
Shu-Jun Fan ◽  
...  

2020 ◽  
Vol 265 ◽  
pp. 114999 ◽  
Author(s):  
Sihan Huang ◽  
Xinyu Zhang ◽  
Jianfeng Huang ◽  
Xiangfeng Lu ◽  
Fangchao Liu ◽  
...  

Author(s):  
Sylvester Dodzi Nyadanu ◽  
Gizachew Assefa Tessema ◽  
Ben Mullins ◽  
Bernard Kumi-Boateng ◽  
Michelle Lee Bell ◽  
...  

Prenatal exposure to ambient air pollution and extreme temperatures are among the major risk factors of adverse birth outcomes and with potential long-term effects during the life course. Although low- and middle-income countries (LMICs) are most vulnerable, there is limited synthesis of evidence in such settings. This document describes a protocol for both an umbrella review (Systematic Review 1) and a focused systematic review and meta-analysis of studies from LMICs (Systematic Review 2). We will search from start date of each database to present, six major academic databases (PubMed, CINAHL, Scopus, MEDLINE/Ovid, EMBASE/Ovid and Web of Science Core Collection), systematic reviews repositories and references of eligible studies. Additional searches in grey literature will also be conducted. Eligibility criteria include studies of pregnant women exposed to ambient air pollutants and/or extreme temperatures during pregnancy with and without adverse birth outcomes. The umbrella review (Systematic Review 1) will include only previous systematic reviews while Systematic Review 2 will include quantitative observational studies in LMICs. Searches will be restricted to English language using comprehensive search terms to consecutively screen the titles, abstracts and full-texts to select eligible studies. Two independent authors will conduct the study screening and selection, risk of bias assessment and data extraction using JBI SUMARI web-based software. Narrative and semi-quantitative syntheses will be employed for the Systematic Review 1. For Systematic Review 2, we will perform meta-analysis with two alternative meta-analytical methods (quality effect and inverse variance heterogeneity) as well as the classic random effect model. If meta-analysis is infeasible, narrative synthesis will be presented. Confidence in cumulative evidence and the strength of the evidence will be assessed. This protocol is registered with PROSPERO (CRD42020200387).


2011 ◽  
Vol 119 (5) ◽  
pp. 598-606 ◽  
Author(s):  
Martine Vrijheid ◽  
David Martinez ◽  
Sandra Manzanares ◽  
Payam Dadvand ◽  
Anna Schembari ◽  
...  

2014 ◽  
Vol 2014 (1) ◽  
pp. 1515
Author(s):  
Ikenna Eze* ◽  
Lars Hemkens ◽  
Heiner Bucher ◽  
Barbara Hoffmann ◽  
Christian Schindler ◽  
...  

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