Nonylphenol and cyproterone acetate effects in the liver and gonads of Lithobates catesbeianus (Anura) tadpoles and juveniles

2021 ◽  
Author(s):  
Lara Salgueiro de Gregorio ◽  
Lilian Franco-Belussi ◽  
Javier Goldberg ◽  
Classius De Oliveira
Keyword(s):  
Cyproterone Acetate ◽  
Lithobates Catesbeianus

Effects of Cyproterone Acetate on Body Weight and Food Intake

1973 ◽  
Author(s):  
William W. Beatty ◽  
Thomas R. Vilberg ◽  
Paul B. Revland
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Cyproterone Acetate

HEMMUNG VON TESTOSTERONABHÄNGIGEN DIFFERENZIERUNGSVORGÄNGEN DER MÄNNLICHEN RATTE NACH DER GEBURT

1967 ◽  
Vol 54 (2) ◽  
pp. 227-240 ◽  
Author(s):  
F. Neumann ◽  
J. D. Hahn ◽  
M. Kramer
Keyword(s):  
Sexual Behaviour ◽  
Cyproterone Acetate ◽  
Post Partum ◽  
Sexual Attitude ◽  
Normal Male ◽  
Corpora Lutea ◽  
List Type ◽  
Newborn Rats ◽  
Neonatal Treatment ◽  
Triangular Shape

ABSTRACT Male newborn rats were injected with 2 mg of an antiandrogen (1,2α-methylene-6-chloro-pregna-4,6-dien-17α-ol-3,20-dione-17α-acetate = cyproterone acetate) daily from their 1st to their 14th day of life. The following effects of this treatment were observed in these animals after onset of sexual maturity: 84% of the animals are unable to reproduce. Penis: the frenulum is broadened to a lamina of triangular shape, which almost completely prevents the preputium from being pushed back. These males show a rather insufficient male sexual behaviour towards females in oestrus. After castration and ovar implantation, some of the treated animals show true corpora lutea and at attempts of cohabitation partially female sexual behaviour towards normal male animals. From these results it can be concluded, that differentiation of the penis is not completed at the time of birth. The infertility of the animals may be caused by the penile changes (difficulties with intromission) as well as by the aimless sexual behaviour. This aimless sexual behaviour, the ability to produce true corpora lutea and finally their partially female sexual attitude under the influence of the hormones from the implanted ovaries led to the conclusion, that the above described neonatal treatment apparently inhibited testosterone-depending post partum developments of sexual differentiation in hypothalamic centers.

CYPROTERONE ACETATE IN THE TREATMENT OF INFANTILE ADRENOGENITAL SYNDROME WITH PRECOCIOUS PUBERTY

1973 ◽  
Vol 71 (4_Suppl) ◽  
pp. S169 ◽  
Author(s):  
J. Beyer ◽  
K. Demisch ◽  
W. Wiegelmann ◽  
J. Happ ◽  
F. Kollmann ◽  
...  
Keyword(s):  
Precocious Puberty ◽  
Cyproterone Acetate ◽  
Adrenogenital Syndrome

REGULATION OF THE ACTIVITIES OF THE ENZYMES INVOLVED IN THE METABOLISM OF STEROID HORMONES IN RAT LIVER: THE EFFECT OF 19-NORTESTOSTERONE AND THE INFLUENCE OF CYPROTERONE ACETATE ON THE ACTION OF TESTOSTERONE AND 5α-DIHYDROTESTOSTERONE

1974 ◽  
Vol 77 (2) ◽  
pp. 287-297 ◽  
Author(s):  
Rüdiger Ghraf ◽  
Edmund Rodney Lax ◽  
Hanns-Georg Hoff ◽  
Herbert Schriefers
Keyword(s):  
Weight Loss ◽  
Body Weight ◽  
Rat Liver ◽  
Enzyme Activities ◽  
Cyproterone Acetate ◽  
Hydroxysteroid Dehydrogenase ◽  
Seminal Vesicles ◽  
Normal Male ◽  
Steroid Hydroxylases ◽  
Drug Leads

ABSTRACT The androgens testosterone and 5α-dihydrotestosterone, the anabolic drug 19-nortestosterone and the anti-androgen cyproterone acetate were investigated with regard to their modifying action on the sexual differentiation of the activities of rat liver enzymes involved in steroid hormone metabolism. The activities of the enzymes (Δ4-5α-hydrogenase, 20-ketoreductase, 3α-and 3β-hydroxysteroid dehydrogenase, NAD- and NADP-dependent Δ4-3β-hydroxysteroid dehydrogenase, total steroid hydroxylases, 7α- and 16α-hydroxylase) were determined in cell-free liver fractions of male animals castrated on day 25 of life and killed on day 90; and of castrated animals which, from day 75 to 89 received daily sc injections (0.3 mg/100 g body weight) of the anabolic drug or the androgen only or in combination with cyproterone acetate (3 mg/100 g body weight). With the exception of 7α-hydroxylase castration leads to a feminization of the enzyme activity pattern. However, the degree of feminization varies from enzyme to enzyme. The administration of testosterone or of 5α-dihydrotestosterone reverses the effect of castration. With 5α-dihydrotestosterone activity values were reached which in some cases were significantly higher than those obtained with testosterone. Although both androgens restored the enzyme activities to the normal male values, neither androgen was able to compensate for the weight loss of the seminal vesicles in the dose administered. The administration of 19-nortestosterone in the same dose as testosterone is only 30 % as effective in restoring the weight loss of the seminal vesicles, but leads to identical activities of Δ4-5α-hydrogenase and of hydroxysteroid dehydrogenases as are found for testosterone. 19-Nortestosterone is without influence on the activities of total steroid hydroxylases and of 16α-hydroxylase. 16α-Hydroxylase is the only enzyme in which the activity enhancing effects of testosterone or of 5α-dihydrotestosterone can be completely blocked by the simultaneous administration of the anti-androgen cyproterone acetate. In all other enzyme activities the anti-androgen does not interfere with the effect of the androgens although it blocks their action on the weight restitution of the seminal vesicles by 60–70 %. 7α-Hydroxylase does not exhibit any androgen dependency. Neither castration nor the subsequent administration of the two androgens, or of the anabolic drug leads to any alterations in activity. However, it is interesting to note that the administration of cyproterone acetate does cause an increase in activity.

TREATMENT OF HIRSUTISM AND OTHER SIGNS OF VIRILISM WITH A REVERSED SEQUENTIAL ADMINISTRATION OF CYPROTERONE ACETATE AND ETHINYL OESTRADIOL CLINICAL AND ENDOCRINOLOGICAL ASPECTS

1971 ◽  
Vol 68 (1_Supplb) ◽  
pp. S172 ◽  
Author(s):  
F. Zielske ◽  
I. Leo-Rossberg ◽  
R. Dreykluft ◽  
A. Römmler ◽  
J. Hammerstein
Keyword(s):  
Cyproterone Acetate ◽  
Sequential Administration ◽  
Ethinyl Oestradiol

Precocious puberty (PP): effects on growth in patients treated with cyproterone acetate (CYP)

1986 ◽  
Vol 113 (1_Suppl) ◽  
pp. S1
Author(s):  
W. SORGO ◽  
E. KIRALY ◽  
M. HAUPENTHAL ◽  
J. HOMOKI ◽  
E. HEINZE ◽  
...  
Keyword(s):  
Precocious Puberty ◽  
Cyproterone Acetate

Effect of lisuride and cyproterone acetate on the prostatic androgen receptor of hypophysectomized rats

1986 ◽  
Vol 113 (1_Suppl) ◽  
pp. S154-S155 ◽  
Author(s):  
H. MOELLER ◽  
TH. GOERLICH ◽  
A. HAUG ◽  
B. GOECKE
Keyword(s):  
Androgen Receptor ◽  
Cyproterone Acetate ◽  
Hypophysectomized Rats

The metabolic effects of metformin, cyproterone-acetate and their combination in women with polycystic ovary syndrome

2019 ◽  
Author(s):  
Ivana Bozic-Antic ◽  
Dusan Ilic ◽  
Tamara Bogavac ◽  
Snjezana Erceg ◽  
Mirjana Lacmanovic ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Cyproterone Acetate ◽  
Polycystic Ovary ◽  
Metabolic Effects ◽  
Ovary Syndrome
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