Prevention of bone resorption by intake of phytoestrogens in postmenopausal women: a meta-analysis

Abstract Objective: We aimed to evaluate the association between coffee and/or tea consumption and breast cancer (BC) risk among premenopausal and postmenopausal women and to conduct a network meta-analysis. Design: Systematic review and network meta-analysis. Setting: We conducted a systematic review of electronic publications in the last 30 years to identify case–control studies or prospective cohort studies that evaluated the effects of coffee and tea intake. Results: Forty-five studies that included more than 3 323 288 participants were eligible for analysis. Network meta-analysis was performed to determine the effects of coffee and/or tea consumption on reducing BC risk in a dose-dependent manner and differences in coffee/tea type, menopause status, hormone receptor and the BMI in subgroup and meta-regression analyses. According to the first pairwise meta-analysis, low-dose coffee intake and high-dose tea intake may exhibit efficacy in preventing ER(estrogen receptor)− BC, particularly in postmenopausal women. Then, we performed another pairwise and network meta-analysis and determined that the recommended daily doses were 2–3 cups/d of coffee or ≥5 cups/d of tea, which contained a high concentration of caffeine, particularly in postmenopausal women. Conclusions: Coffee and tea consumption is not associated with a reduction in the overall BC risk in postmenopausal women and is associated with a potentially lower risk of ER− BC. And the highest recommended dose is 2–3 cups of coffee/d or ≥5 cups of tea/d. They are potentially useful dietary protectants for preventing BC.

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Retraction Note: Associations between VDR Gene Polymorphisms and Osteoporosis Risk and Bone Mineral Density in Postmenopausal Women: A systematic review and Meta-Analysis

Scientific Reports ◽

10.1038/s41598-021-88654-1 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Liang Zhang ◽

Xin Yin ◽

Jingcheng Wang ◽

Daolinag Xu ◽

Yongxiang Wang ◽

...

Keyword(s):

Bone Mineral Density ◽

Systematic Review ◽

Postmenopausal Women ◽

Bone Mineral ◽

Gene Polymorphisms ◽

Meta Analysis ◽

Mineral Density ◽

Vdr Gene ◽

Vdr Gene Polymorphisms ◽

Osteoporosis Risk

Editor's Note: this Article has been retracted; the Retraction Note is available at https://doi.org/10.1038/s41598-021-88654-1.

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Raloxifene as an adjunctive treatment for postmenopausal women with schizophrenia: a meta-analysis of randomized controlled trials

Archives of Women s Mental Health ◽

10.1007/s00737-017-0773-2 ◽

2017 ◽

Vol 21 (1) ◽

pp. 31-41 ◽

Cited By ~ 8

Author(s):

Qi Wang ◽

Xiaomei Dong ◽

Yan Wang ◽

Xiaobai Li

Keyword(s):

Randomized Controlled Trials ◽

Postmenopausal Women ◽

Meta Analysis ◽

Adjunctive Treatment ◽

Controlled Trials ◽

Randomized Controlled

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No Interaction Effect between Interleukin-6 Polymorphisms and Acid Ash Diet with Bone Resorption Marker in Postmenopausal Women

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18020827 ◽

2021 ◽

Vol 18 (2) ◽

pp. 827

Author(s):

Sook Yee Lim ◽

Yoke Mun Chan ◽

Vasudevan Ramachandran ◽

Zalilah Mohd Shariff ◽

Yit Siew Chin ◽

...

Keyword(s):

Bone Resorption ◽

Postmenopausal Women ◽

Interaction Effect ◽

Interleukin 6 ◽

Gene Polymorphisms ◽

Bone Resorption Marker ◽

Dietary Intakes ◽

Dietary Acid Load ◽

Dietary Acid ◽

Acid Load

Background: Evidence is growing that a high-acid diet might accelerate the rate of bone loss, and gene polymorphisms such as Interleukin 6 (IL6) -174G/C and -572G/C are related to bone deterioration. However, no study of the interaction between diet and IL6 polymorphisms has been conducted among Asians. Thus, the objective of this study was to determine whether IL6 gene polymorphisms modified the association between dietary acidity and the rate of bone resorption. Methods: This cross-sectional study recruited 203 postmenopausal women (age ranged from 51 to 85 years old) in community settings. The dietary intakes of the participants were assessed using a validated interviewer-administered semi-quantitative food frequency questionnaire (FFQ), while dietary acid load (DAL) was estimated using net endogenous acid production (NEAP). Agena® MassARRAY genotyping analysis and serum collagen type 1 cross-linked C-telopeptide (CTX1) were used to identify the IL6 genotype and as a bone resorption marker, respectively. The interactions between diet and single-nucleotide polymorphisms (SNPs) were assessed using linear regressions. Results: A total of 203 healthy postmenopausal women aged between 51 and 85 years participated in this study. The mean BMI of the participants was 24.3 kg/m2. In IL6 -174 G/C, all the participants carried the GG genotype, while the C allele was absent. Approximately 40% of the participants had a high dietary acid load. Dietary acid load (B = 0.15, p = 0.031) and the IL6 -572 CC genotype group (B = 0.14, p = 0.044) were positively associated with a higher bone resorption. However, there was no moderating effect of the IL6 genetic polymorphism on the relationship between and acid ash diet and bone resorption markers among the postmenopausal women (p = 0.79). Conclusion: High consumption of an acid ash diet and the IL6 -572 C allele seem to attribute to high bone resorption among postmenopausal women. However, our finding does not support the interaction effect of dietary acidity and IL6 (-174G/C and -572G/C) polymorphisms on the rate of bone resorption. Taken together, these results have given scientific research other candidate genes to focus on which may interact with DAL on bone resorption, to enhance planning for preventing or delaying the onset of osteoporosis among postmenopausal women.

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