Effects of sleep deprivation on endothelial function in adult humans: a systematic review

Sleep is critical for the maintenance of physiological homeostasis and, as such, inadequate sleep beckons a myriad of pathologies. Sleep deprivation is a growing health concern in contemporary society since short sleep durations are associated with increased cardiovascular disease risk and atherosclerotic plaque development. Vascular endothelial dysfunction is an antecedent to atherosclerosis and cardiovascular disease. Herein, we review seminal literature indicating that short sleep durations attenuate endothelial function and explore more recent evidence indicating that sleep deprivation perturbs autonomic balance and the circadian rhythmicity of peripheral vascular clock components. We further examine literature that indicates a mechanistic link between short sleep duration and endothelial dysfunction and subsequent morbidity. Understanding the mechanisms that regulate endothelial function in the context of sleep deprivation facilitates the development and optimization of interventions, such as exercise, that mitigate the ramifications of inadequate sleep on vascular function and cardiovascular health. Listen to this article’s corresponding podcast at https://ajpheart.podbean.com/e/sleep-deprivation-and-endothelial-function/

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Effect of Sodium-Glucose Cotransporter-2 Inhibitors on Endothelial Function: A Systematic Review of Preclinical Studies

Diabetes Therapy ◽

10.1007/s13300-020-00885-z ◽

2020 ◽

Vol 11 (9) ◽

pp. 1947-1963

Author(s):

Afnan S. Alshnbari ◽

Sophie A. Millar ◽

Saoirse E. O’Sullivan ◽

Iskandar Idris

Keyword(s):

Systematic Review ◽

Endothelial Function ◽

Preclinical Studies ◽

Sodium Glucose Cotransporter

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Effectiveness of Sleep Deprivation in Treating Acute Bipolar Depression as Augmentation Strategy: A Systematic Review and Meta-Analysis

Frontiers in Psychiatry ◽

10.3389/fpsyt.2020.00070 ◽

2020 ◽

Vol 11 ◽

Cited By ~ 3

Author(s):

Juan P. Ramirez-Mahaluf ◽

Enzo Rozas-Serri ◽

Fernando Ivanovic-Zuvic ◽

Luis Risco ◽

Paul A. Vöhringer

Keyword(s):

Systematic Review ◽

Sleep Deprivation ◽

Bipolar Depression ◽

Meta Analysis ◽

Augmentation Strategy

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Sleep Deprivation and Oxidative Stress in Animal Models: A Systematic Review

Oxidative Medicine and Cellular Longevity ◽

10.1155/2015/234952 ◽

2015 ◽

Vol 2015 ◽

pp. 1-15 ◽

Cited By ~ 62

Author(s):

Gabriel Villafuerte ◽

Adán Miguel-Puga ◽

Eric Murillo Rodríguez ◽

Sergio Machado ◽

Elias Manjarrez ◽

...

Keyword(s):

Oxidative Stress ◽

Systematic Review ◽

Sleep Deprivation ◽

Meta Analysis ◽

Exclusion Criteria ◽

Antioxidative Properties ◽

Search Terms ◽

Antioxidant Function ◽

Basic Studies ◽

And Oxidative Stress

Because the function and mechanisms of sleep are partially clear, here we applied a meta-analysis to address the issue whether sleep function includes antioxidative properties in mice and rats. Given the expansion of the knowledge in the sleep field, it is indeed ambitious to describe all mammals, or other animals, in which sleep shows an antioxidant function. However, in this paper we reviewed the current understanding from basic studies in two species to drive the hypothesis that sleep is a dynamic-resting state with antioxidative properties. We performed a systematic review of articles cited in Medline, Scopus, and Web of Science until March 2015 using the following search terms:Sleep or sleep deprivation and oxidative stress, lipid peroxidation, glutathione, nitric oxide, catalase or superoxide dismutase. We found a total of 266 studies. After inclusion and exclusion criteria, 44 articles were included, which are presented and discussed in this study. The complex relationship between sleep duration and oxidative stress is discussed. Further studies should consider molecular and genetic approaches to determine whether disrupted sleep promotes oxidative stress.

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