The Evaluation of the Eighth Edition of the AJCC/UICC Staging System for Intrahepatic Cholangiocarcinoma: a Proposal of a Modified New Staging System

2019 ◽  
Vol 24 (4) ◽  
pp. 786-795 ◽  
Author(s):  
Yusuke Yamamoto ◽  
Teiichi Sugiura ◽  
Yukiyasu Okamura ◽  
Takaaki Ito ◽  
Ryo Ashida ◽  
...  
Keyword(s):  
Intrahepatic Cholangiocarcinoma ◽  
Staging System ◽  
Eighth Edition ◽  
Uicc Staging System

Postoperative nomogram for predicting survival after resection for intrahepatic cholangiocarcinoma.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. 4129-4129
Author(s):  
Dario Ribero ◽  
Stefano Rosso ◽  
Antonio Daniele Pinna ◽  
Gennaro Nuzzo ◽  
Alfredo Guglielmi ◽  
...  
Keyword(s):  
Intrahepatic Cholangiocarcinoma ◽  
Missing Values ◽  
Cox Regression ◽  
Predictive Accuracy ◽  
Tumour Size ◽  
Staging System ◽  
Internal Validation ◽  
Staging Systems ◽  
Patient Prognosis ◽  
Uicc Staging System

4129 Background: Conventional staging systems have limited value for survival estimation in individual patients because of the multiple predictors of outcome. Nomograms may overcome these limitations. Thus we developed and internally validated a postoperative nomogram to predict survival after resection of intrahepatic cholangiocarcinoma (IHC) and compared its predictions to those obtained using the 7th Ed. AJCC/UICC stage groupings. Methods: Prospective clinicopathologic data from 574 patients who underwent hepatic resection at 12 tertiary hepatobiliary centres (1995-2011) were used. After inputting missing values with regression imputation, the nomogram was developed from a Cox regression model with overall survival (OS) as the primary end-point. Calibration and internal validation were performed calculating the agreement between observed and predicted outcomes in terms of percentage of predicted errors (PE). Discrimination was quantified with the concordance index (CI). Both CI and PE were then corrected for over-optimism using bootstrapping with 100-fold cross-validation sampling. Credibility intervals around 3- and 5-year predicted survival were estimated from an empirical Bayesian model. Results: At last follow-up (median duration 27.6 months) 243 patients had died. Three and five-years OS were 52% and 39%. The predictive accuracy of the nomogram (CI: 66.5), which includes 7 variables (tumour size and number, lymph-node metastases, vascular invasion, perineural invasion, CA19.9 level, and radicality of resection), was good and superior to that of the current AJCC/UICC staging system (CI: 58.4). Percentage of PE for the AJCC/UICC staging system were 24%, while the studied model offered a PE slightly under 20%. Heterogeneity was observed in the distribution of nomogram-predicted survival probabilities within stage groups. Conclusions: The nomogram developed in this study overcomes some of the prognostic limitations associated with simple models by including all prognostic variables excluded from the AJCC/UICC staging system and may serve as an instrument for future refinements in determining individual patient prognosis necessary for accurate patients stratification.

Comparison between the seventh and eighth edition of the AJCC/UICC staging system for nasopharyngeal cancer integrated with pretreatment plasma Epstein–Barr virus DNA level in a non-Chinese population: secondary analysis from a prospective randomized trial

2019 ◽  
Vol 49 (12) ◽  
pp. 1100-1113 ◽  
Author(s):  
Sarin Kitpanit ◽  
Nutchawan Jittapiromsak ◽  
Aniwat Sriyook ◽  
Anussara Prayongrat ◽  
Danita Kannarunimit ◽  
...  
Keyword(s):  
Epstein Barr Virus ◽  
Nasopharyngeal Cancer ◽  
Secondary Analysis ◽  
Staging System ◽  
Barr Virus ◽  
Previous Edition ◽  
Ebv Dna ◽  
Epstein Barr ◽  
Eighth Edition ◽  
Uicc Staging System

The eighth AJCC/UICC staging for nasopharyngeal cancer had higher prognostic values than the previous edition. Pretreatment plasma EBV DNA integrated into the next edition could further improve the outcome prediction.

scholarly journals Predicting recurrence of papillary thyroid cancer using the eighth edition of the AJCC/UICC staging system

2019 ◽  
Vol 106 (7) ◽  
pp. 889-897 ◽  
Author(s):  
N. Chereau ◽  
T. O. Oyekunle ◽  
A. Zambeli‐Ljepović ◽  
H. S. Kazaure ◽  
S. A. Roman ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Staging System ◽  
Papillary Thyroid ◽  
Eighth Edition ◽  
Uicc Staging System

Proposed Modification of the Eighth Edition of the AJCC Staging System for Intrahepatic Cholangiocarcinoma

HPB ◽  
2021 ◽  
Author(s):  
Xu-Feng Zhang ◽  
Feng Xue ◽  
Jin He ◽  
Sorin Alexandrescu ◽  
Hugo P. Marques ◽  
...  
Keyword(s):  
Intrahepatic Cholangiocarcinoma ◽  
Staging System ◽  
Ajcc Staging System ◽  
Proposed Modification ◽  
Eighth Edition ◽  
Ajcc Staging

scholarly journals Macroscopic types of intrahepatic cholangiocarcinoma and the eighth edition of AJCC/UICC TNM staging system

Oncotarget ◽  
2017 ◽  
Vol 8 (60) ◽  
pp. 101165-101174 ◽  
Author(s):  
Ze-Wu Meng ◽  
Wei Pan ◽  
Hai-Jie Hong ◽  
Jiang-Zhi Chen ◽  
Yan-Ling Chen
Keyword(s):  
Intrahepatic Cholangiocarcinoma ◽  
Staging System ◽  
Tnm Staging ◽  
Tnm Staging System ◽  
Eighth Edition

scholarly journals Validation of the Proposed cN2 Subclassification in the Eighth Edition of the IASLC Staging System: A Prospective Phase II Multicenter Study

2020 ◽  
Vol 1 (2) ◽  
pp. 100019
Author(s):  
Jiro Abe ◽  
Yuji Matsumura ◽  
Satoshi Shiono ◽  
Masaya Aoki ◽  
Masami Sato ◽  
...  
Keyword(s):  
Phase Ii ◽  
Multicenter Study ◽  
Staging System ◽  
System A ◽  
Prospective Phase ◽  
Eighth Edition

scholarly journals Conjunctival melanoma treatment outcomes in 288 patients: a multicentre international data-sharing study

2020 ◽  
pp. bjophthalmol-2020-316293
Author(s):  
Puneet Jain ◽  
Paul T Finger ◽  
Maria Fili ◽  
Bertil Damato ◽  
Sarah E Coupland ◽  
...  
Keyword(s):  
Local Recurrence ◽  
Local Excision ◽  
External Beam Radiotherapy ◽  
Staging System ◽  
Primary Treatment ◽  
Excision Biopsy ◽  
Conjunctival Melanoma ◽  
Recurrence Rates ◽  
Increased Risk ◽  
Eighth Edition

BackgroundTo relate conjunctival melanoma characteristics to local control.MethodsRetrospective, registry-based interventional study with data gathered from 10 ophthalmic oncology centres from 9 countries on 4 continents. Conjunctival melanoma patients diagnosed between January 2001 and December 2013 were enrolled in the study. Primary treatments included local excision, excision with cryotherapy and exenteration. Adjuvant treatments included topical chemotherapy, brachytherapy, proton and external beam radiotherapy (EBRT). Cumulative 5-year and 10-year Kaplan-Meier local recurrence rates were related to clinical and pathological T-categories of the eighth edition of the American Joint Committee on Cancer (AJCC) staging system.Results288 patients had a mean initial age of 59.7±16.8 years. Clinical T-categories (cT) were cT1 (n=218,75.7%), cT2 (n=34, 11.8%), cT3 (n=15, 5.2%), cTx (n=21,7.3%) with no cT4. Primary treatment included local excision (n=161/288, 55.9%) followed by excision biopsy with cryotherapy (n=108/288, 37.5%) and exenteration (n=5/288, 1.7%). Adjuvant therapies included topical mitomycin (n=107/288, 37.1%), plaque-brachytherapy (n=55/288, 19.1%), proton-beam (n=36/288, 13.5%), topical interferon (n=20/288, 6.9%) and EBRT (n=15/288, 5.2%). Secondary exenteration was performed (n=11/283, 3.9%). Local recurrence was noted in 19.1% (median=3.6 years). Cumulative local recurrence was 5.4% (3.2–8.9%), 19.3% (14.4–25.5%) and 36.9% (26.5–49.9%) at 1, 5 and 10 years, respectively. cT3 and cT2 tumors were twice as likely to recur than cT1 tumours, but only cT3 had statistically significantly greater risk of local recurrence than T1 (p=0.013). Factors such as tumour ulceration, plica or caruncle involvement and tumour thickness were not significantly associated with an increased risk of local recurrence.ConclusionThis multicentre international study showed that eighth edition of AJCC tumour staging was related to the risk of local recurrence of conjunctival melanoma after treatment. The 10-year cumulative local recurrence remains high despite current management.

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