Immortalization of human melanocytes does not alter the de novo properties of nitric oxide to induce cell detachment from extracellular matrix components via cGMP

2008 ◽  
Vol 44 (8-9) ◽  
pp. 385-395 ◽  
Author(s):  
Krassimira Ivanova ◽  
Britta Lambers ◽  
Rene van den Wijngaard ◽  
I. Caroline Le Poole ◽  
Olga Grigorieva ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Extracellular Matrix ◽  
De Novo ◽  
Cell Detachment ◽  
Human Melanocytes ◽  
Extracellular Matrix Components ◽  
Matrix Components

scholarly journals Effects of nitric oxide on the adhesion of human melanocytes to extracellular matrix components

1997 ◽  
Vol 183 (4) ◽  
pp. 469-476 ◽  
Author(s):  
Krassimira Ivanova ◽  
Isabel Caroline Le Poole ◽  
Rupert Gerzer ◽  
Wiete Westerhof ◽  
Pranab Kummar Das
Keyword(s):  
Nitric Oxide ◽  
Extracellular Matrix ◽  
Human Melanocytes ◽  
Extracellular Matrix Components ◽  
Matrix Components

scholarly journals Exogenous nitric oxide inhibits mesangial cell adhesion to extracellular matrix components

1998 ◽  
Vol 53 (3) ◽  
pp. 598-608 ◽  
Author(s):  
Jian Yao ◽  
Harald O. Schoecklmann ◽  
Felicitas Pröls ◽  
Stefan Gauer ◽  
R. Bernd Sterzel
Keyword(s):  
Nitric Oxide ◽  
Extracellular Matrix ◽  
Cell Adhesion ◽  
Mesangial Cell ◽  
Extracellular Matrix Components ◽  
Exogenous Nitric Oxide ◽  
Matrix Components

A single-component hydrogel bioink for bioprinting of bioengineered 3D constructs for dermal tissue engineering

2018 ◽  
Vol 5 (6) ◽  
pp. 1100-1111 ◽  
Author(s):  
Rúben F. Pereira ◽  
Aureliana Sousa ◽  
Cristina C. Barrias ◽  
Paulo J. Bártolo ◽  
Pedro L. Granja
Keyword(s):  
Tissue Engineering ◽  
Extracellular Matrix ◽  
De Novo ◽  
Single Component ◽  
Biophysical Properties ◽  
Dermal Tissue ◽  
Extracellular Matrix Components ◽  
Matrix Components

Bioprinted dual-crosslinked 3D constructs with tunable biochemical and biophysical properties guide the de novo deposition of extracellular matrix components of dermal tissue.

scholarly journals Matrix Metalloproteinases and Arterial Hypertension: Role of Oxidative Stress and Nitric Oxide in Vascular Functional and Structural Alterations

Biomolecules ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 585
Author(s):  
Alejandro F. Prado ◽  
Rose I. M. Batista ◽  
Jose E. Tanus-Santos ◽  
Raquel F. Gerlach
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Extracellular Matrix ◽  
Vascular Function ◽  
Vascular Dysfunction ◽  
Protective Effects ◽  
Pathophysiological Mechanisms ◽  
Emerging Therapies ◽  
Extracellular Matrix Components ◽  
Matrix Components

Various pathophysiological mechanisms have been implicated in hypertension, but those resulting in vascular dysfunction and remodeling are critical and may help to identify critical pharmacological targets. This mini-review article focuses on central mechanisms contributing to the vascular dysfunction and remodeling of hypertension, increased oxidative stress and impaired nitric oxide (NO) bioavailability, which enhance vascular matrix metalloproteinase (MMP) activity. The relationship between NO, MMP and oxidative stress culminating in the vascular alterations of hypertension is examined. While the alterations of hypertension are not fully attributable to these pathophysiological mechanisms, there is strong evidence that such mechanisms play critical roles in increasing vascular MMP expression and activity, thus resulting in abnormal degradation of extracellular matrix components, receptors, peptides, and intracellular proteins involved in the regulation of vascular function and structure. Imbalanced vascular MMP activity promotes vasoconstriction and impairs vasodilation, stimulating vascular smooth muscle cells (VSMC) to switch from contractile to synthetic phenotypes, thus facilitating cell growth or migration, which is associated with the deposition of extracellular matrix components. Finally, the protective effects of MMP inhibitors, antioxidants and drugs that enhance vascular NO activity are briefly discussed. Newly emerging therapies that address these essential mechanisms may offer significant advantages to prevent vascular remodeling in hypertensive patients.

scholarly journals Production and utilization of extracellular matrix components by human melanocytes

1989 ◽  
Vol 180 (2) ◽  
pp. 314-325 ◽  
Author(s):  
Brian K. McClenic ◽  
Raj S. Mitra ◽  
Bruce L. Riser ◽  
Brian J. Nickoloff ◽  
Vishva M. Dixit ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Human Melanocytes ◽  
Extracellular Matrix Components ◽  
Matrix Components

Expression of extracellular matrix components and cytokine receptors in human fibrocytes during rheumatoid arthritis

2021 ◽  
pp. 1-12
Author(s):  
Dorra Elhaj Mahmoud ◽  
Wajih Kaabachi ◽  
Nadia Sassi ◽  
Amel Mokhtar ◽  
Lobna Ben Ammar ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Extracellular Matrix ◽  
Cytokine Receptors ◽  
Extracellular Matrix Components ◽  
Matrix Components
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